Propolis and its direct and indirect hypoglycemic effect

Al-Hariri, Mohammed

doi:10.4103/2230-8229.90015

Cited by 28 publications

(25 citation statements)

References 20 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Lipid disorders assume a position of utmost importance in patients with diabetes, because of the high risk of microvascular disease in this condition but administration of N. propolis to the rats was able to reverse hyperlipidemia seen in the diabetic rats. Similar reports of Al-Hariri [ 29 ] and El-Sayed et al . [ 31 ] shows that treatment with propolis can reduce the TG and serum cholesterol level in diabetics.…”

Section: Discussionsupporting

confidence: 90%

“…In the propolis treated groups, despite the initial hyperglycemia, the antioxidants present in propolis were able to prevent oxidative stress effect of hyperglycemia on the liver and pancreas, this finding is in line with the reports of Al-Hariri et al . [ 29 ] who reported the efficacy of Arabian propolis in hyperglycemia. Hypoglycemic agents exact their effects via direct or indirect mechanisms in diabetes rats [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Hepatoprotective and Pancreatoprotective Properties of the Ethanolic Extract of Nigerian Propolis

Ibrahim¹,

Amin²,

Mustafa³

et al. 2015

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

Objective:Increased oxidative stress is associated with the progression of diabetic mellitus. In the present study, we investigated the effects of the ethanolic extract of Nigerian propolis (N. propolis) on markers of oxidative stress, histology of the liver and pancreas and glycaemia in alloxan-induced diabetic rats.Materials and Methods:Alloxan-induced hyperglycemic Wistar rats were treated with either metformin (150 mg/kg/d) or N. propolis (200 mg/kg/d and 300 mg/kg/d) for 28 days. At the end of the treatment period, the rats were sacrificed; blood was collected for biochemical analysis while their pancreases and liver were excised and processed for histological studies.Results:Serum oxidative stress markers and blood glucose concentration were compared between the treated and control rats. In contrast to the non-treated diabetic rats, blood glucose concentration were not significantly different between treated rats and control (P < 0.05) at 28 days of treatment with N. propolis and metformin. Serum malondialdehyde levels was reduced while superoxide dismutase levels were elevated in the N. propolis group; these levels were converse in the diabetic group, these differences are statistically significant (P<0.05) when compared with the control. Histologically, there was improvement in the treated group compared to the untreated group.Conclusion:These findings suggest that the N. propolis confers protection against hyperglycemia-induced oxidative stress in both liver and pancreas of adult Wistar rats.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and Pancreatoprotective Properties of the Ethanolic Extract of Nigerian Propolis

Ibrahim¹,

Amin²,

Mustafa³

et al. 2015

J Intercult Ethnopharmacol

View full text Add to dashboard Cite

show abstract

“…Moreover, administration of PRS and L. acidophilus prevented rats against CCl4-induced hyperglycemia. Even though the presence of bioactive components preventing beta-cell apoptosis and enhancing insulin secretion has been hypothesized, 29 the precise molecular mechanism has not been deciphered so far. The stimulation of GLUT4 translocation in skeletal muscle, which enhanced glucose uptake, 30 the down regulation of glucose-6-phosphatase, 31 as well as the modulation of the anti-inflammatory and immunomodulatory activities through the NF-κB pathway 32 have been proposed however.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Propolis and Probiotic Lactobacillus acidophilus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

et al. 2019

View full text Add to dashboard Cite

Background: Propolis (PRS) and probiotic bacteria Lactobacillus are natural products used as dietary supplement for their therapeutic benefits. This study was performed to examine the possible hepatoprotective effect of PRS and probiotics (PRCs) against carbon tetrachloride-induced liver injury. Methods: Experimentally, intoxicated rats received 0.5 ml/kg CCl4 (i.p.) daily for six days, pretreated rats received per os PRS 100 mg/kg or PRCs 109 CFU for six days followed by a single dose of 0.5 ml/kg CCl4. Control groups received either PRS, PRCs or olive oil for six days. Then, serum biochemistry (total protein, cholesterol, triglycerides and albumin) and oxidative stress parameters were measured. Results: We showed that CCl4 treatment was associated with an increase of the serum aspartate amino transferase (AST), alanine aminotransferase (ALT), cholesterol and triglycerides levels. In parallel, serum total protein, albumin and blood sugar levels were significantly decreased. Regarding the oxidative stress parameters, catalase and glutathione S-transferase (GST) levels were lower, conversely to the lipid peroxidation (MDA). Conclusion: Our results strongly support that administration of PRS and PRCs may significantly protect liver against CCl4-induced toxicity by enhancing antioxidative stress pathway and preventing lipid peroxidation.

show abstract

“…Propolis (bee glue) is a natural resinous mixture produced by honey bees by combining bee-released compounds with exudate gathered from various plant sources [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Green Brazilian Propolis Alcohol Extract on Nociceptive Pain Models in Rats

Al-Hariri

Abualait

2020

Plants

View full text Add to dashboard Cite

Pain is one of the most common symptoms encountered in the medical practice. None of the management procedures used currently offer a complete relief for patients suffering from nociceptive pain. New treatment strategies for pain management are needed. Propolis has been used in traditional medicine to relieve various types of pain. The aim of the current study was to investigate the potential effects of the green Brazilian propolis alcohol extract in vivo on the nociceptive and inflammatory pain models in rats. Rats were distributed into three random groups (n = 6); Group I: control group received normal saline intraperitoneally (i.p.); Group II: treated with green Brazilian propolis alcohol extract (P50 mg/kg i.p.); Group III: treated with P100 mg/kg i.p. After sixty minutes, 50 μL of 5% formalin was injected subcutaneously into the dorsal surface of the right hind paw. The nociceptive response was identified by counting the number of flinches of the injected paw. The number of flinches was counted for the period of 0–5 min (early phase; neurogenic) and 10–60 min (late phase; inflammatory). Thermal hyperalgesia was assessed using three-paw withdrawal latency measurement with ten minutes intervals using a planter analgesic meter. Abdominal writhe (contraction) was induced by i.p. injection of acetic acid (1 mL of 2%). The results showed that green Brazilian propolis alcohol extract caused a significant inhibition of acetic acid-induced pain and significantly increased the pain threshold against infrared and formalin tests. The promising antinociceptive and anti-inflammatory properties of propolis and/or its active constituents as natural compounds in the present study indicates that it merits further studies in pain.

show abstract

Propolis and its direct and indirect hypoglycemic effect

Cited by 28 publications

References 20 publications

Hepatoprotective and Pancreatoprotective Properties of the Ethanolic Extract of Nigerian Propolis

Hepatoprotective and Pancreatoprotective Properties of the Ethanolic Extract of Nigerian Propolis

Protective Effects of Propolis and Probiotic Lactobacillus acidophilus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Effects of Green Brazilian Propolis Alcohol Extract on Nociceptive Pain Models in Rats

Contact Info

Product

Resources

About