Propolis and Diet Rich in Polyphenols as Cariostatic Agents Reducing Accumulation of Dental Plaque

Kurek-Górecka, Anna; Walczyńska-Dragon, Karolina; Felitti, Rafael; Baron, Stefan; Olczyk, Paweł

doi:10.3390/molecules27010271

Cited by 13 publications

(14 citation statements)

References 78 publications

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“…These compounds also play essential roles in antioxidant, antibacterial, immunomodulatory, and wound‐healing activities (Oryan et al, 2018). Based on the literature, polyphenolic compounds of propolis possess cariogenic properties and reduce the accumulation of dental plaques and improve oral health (Kurek‐Gorecka et al, 2022).…”

Section: Resultsmentioning

confidence: 99%

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Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis

Fathi Hafshejani

Lotfi

Rezvannejad

et al. 2023

Food Science & Nutrition

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Propolis is a resinous substance produced by honey bees that is very popular as a natural remedy in traditional medicine. The current research is the first study on the biological properties of ethanolic extracts of propolis (EEP) from several different regions (12) of Iran. Total phenolic and flavonoid contents (TPC and TFC) of Iranian EEPs were variable between 26.59-221.38 mg GAE/g EEP and 4.8-100.03 mg QE/g EEP. The DPPH scavenging assay showed all the studied EEP samples, except for the sample with the lowest TPC and TFC (P6), have suitable antioxidant activity. All the EEPs inhibited both cholinesterase enzymes (acetylcholinesterase: AChE, butyrylcholinesterase: BuChE) but most of them exhibited a distinct selectivity over BuChE.Evaluation of the antibacterial activity of the EEP samples using four pathogenic bacteria (B. cereus, S. aureus, A. baumannii, and P. aeruginosa) demonstrated that the antibacterial properties of propolis are more effective on the gram-positive bacterium.Spearman correlation analysis showed a strong positive correlation between TPC and TFC of the Iranian EEPs and their antioxidant, anticholinesterase, and antibacterial activities. Considering that there is ample evidence of anticholinesterase activity of flavonoids and a significant correlation between the anticholinesterase activity of the studied Iranian EEPs and their total flavonoid content was observed, the interaction of 17 well-known propolis flavonoids with AChE and BuChE was explored using molecular docking. The results indicated that all the flavonoids interact with the active site gorge of both enzymes with high affinity. Summing up, the obtained results suggest that Iranian propolis possesses great potential for further studies.

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Section: Resultsmentioning

confidence: 99%

“…Based on the literature, polyphenolic compounds of propolis possess cariogenic properties and reduce the accumulation of dental plaques and improve oral health (Kurek-Gorecka et al, 2022).…”

Section: Tpc Tfc and Antioxidant Potencymentioning

confidence: 99%

Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis

Fathi Hafshejani

Lotfi

Rezvannejad

et al. 2023

Food Science & Nutrition

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“…In chronic periodontitis, compared to healthy gingiva, the concentrations of pro-inflammatory cytokines, such as IL-1β, IL-6, TNF-α, and inflammatory mediators, like prostaglandins and metalloproteinases, increase significantly. This can result in the destabilization of the atherosclerotic plaque, which is a major cause of acute coronary syndromes and myocardial infarction [ 3 ]. In vitro and in vivo studies have shown that natural compounds, including propolis, possess anti-inflammatory [ 22 ], antioxidant [ 23 ], anticancer [ 24 ], neuroprotective [ 25 ], antiviral [ 26 ], antibacterial [ 27 ], or immunomodulatory properties [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…Periodontal disease is caused by bacterial infection of the gums, periodontium, adjacent alveolar bone, and root cement. Among the bacteria which are responsible for inflammation in periodontal tissue are Porphyromonas gingivalis , Treponema denticola , Tannarella forsythia , Bacteroides forsythus , Aggregatibacter actinomycetemcommitans , Prevotella intermedia , Streptococcus sanguis , and Fusobacterium nucleatum [ 2 , 3 ]. Bacteria and their products present in the biofilm stimulate immunocompetent cells to produce and release inflammatory mediators.…”

Section: Introductionmentioning

confidence: 99%

Ethanolic Extract of Propolis and CAPE as Cardioprotective Agents against LPS and IFN-α Stressed Cardiovascular Injury

Kurek-Górecka,

Kłósek,

Pietsz

et al. 2024

Nutrients

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The inflammatory process is triggered by several factors such as toxins, pathogens, and damaged cells, promoting inflammation in various systems, including the cardiovascular system, leading to heart failure. The link between periodontitis as a chronic inflammatory disease and cardiovascular disease is confirmed. Propolis and its major component, caffeic acid phenethyl ester (CAPE), exhibit protective mechanisms and anti-inflammatory effects on the cardiovascular system. The objective of the conducted study was to assess the anti-inflammatory effects of the Polish ethanolic extract of propolis (EEP) and its major component—CAPE—in interferon-alpha (IFN-α), lipopolysaccharide (LPS), LPS + IFN-α-induced human gingival fibroblasts (HGF-1). EEP and CAPE were used at 10–100 µg/mL. A multiplex assay was used for interleukin and adhesive molecule detection. Our results demonstrate that EEP, at a concentration of 25 µg/mL, decreases pro-inflammatory cytokine IL-6 in LPS-induced HGF-1. At the same concentration, EEP increases the level of anti-inflammatory cytokine IL-10 in LPS + IFN-α-induced HGF-1. In the case of CAPE, IL-6 in LPS and LPS + IFN-α induced HGF-1 was decreased in all concentrations. However, in the case of IL-10, CAPE causes the highest increase at 50 µg/mL in IFN-α induced HGF-1. Regarding the impact of EEP on adhesion molecules, there was a noticeable reduction of E-selectin by EEP at 25, 50, and100 µg/mL in IFN-α -induced HGF-1. In a range of 10–100 µg/mL, EEP decreased endothelin-1 (ET-1) during all stimulations. CAPE statistically significantly decreases the level of ET-1 at 25–100 µg/mL in IFN-α and LPS + IFN-α. In the case of intercellular adhesion molecule-1 (ICAM-1), EEP and CAPE downregulated its expression in a non-statistically significant manner. Based on the obtained results, EEP and CAPE may generate beneficial cardiovascular effects by influencing selected factors. EEP and CAPE exert an impact on cytokines in a dose-dependent manner.

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“…Gingivitis and periodontitis may last for months or years and spread slowly the body when the bacteria enter the blood stream, leading to the release of a variety of inflammatory mediators [ 56 , 57 ]. Dental plaque, a unique biofilm, contains a wide variety of bacteria, viruses, and fungi [ 58 ]. Oral bacteria can be sub-classified according to their oxygen requirements.…”

Section: Orodental Healthmentioning

confidence: 99%

The Link between Stroke Risk and Orodental Status—A Comprehensive Review

Shahi

Farhoudi

Dizaj

et al. 2022

JCM

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One of the primary causes of disability and mortality in the adult population worldwide is stroke. A person’s general health is significantly impacted by their oral and dental health. People who have poor oral health are more susceptible to conditions such as stroke. Stroke risk has long been linked to oral and dental conditions. The risk of stroke and its cost impact on the healthcare systems appear to be significantly reduced as a result of the decline in the incidence and prevalence of oral and dental illnesses. Hypothetically, better management of oral hygiene and dental health lead to reduced stroke risk. To the authors’ best knowledge, for the first time, the potential link between dental health and stroke were cross-examined. The most typical stroke symptoms, oral and dental illnesses linked to stroke, and the role of oral healthcare professionals in stroke prevention are revealed. The potential mediating processes and subsequent long-term cognitive and functional neurological outcomes are based on the available literature. It must be noted that periodontal diseases and tooth loss are two common oral health measures. Lack of knowledge on the effects of poor oral health on systemic health together with limited access to primary medical or dental care are considered to be partially responsible for the elevated risk of stroke. Concrete evidence confirming the associations between oral inflammatory conditions and stroke in large cohort prospective studies, stratifying association between oral disease severity and stroke risk and disease effects on stroke survival will be desirable. In terms of clinical pathology, a predictive model of stroke as a function of oral health status, and biomarkers of systemic inflammation could be useful for both cardiologists and dentists.

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Propolis and Diet Rich in Polyphenols as Cariostatic Agents Reducing Accumulation of Dental Plaque

Cited by 13 publications

References 78 publications

Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis

Correlation between total phenolic and flavonoid contents and biological activities of 12 ethanolic extracts of Iranian propolis

Ethanolic Extract of Propolis and CAPE as Cardioprotective Agents against LPS and IFN-α Stressed Cardiovascular Injury

The Link between Stroke Risk and Orodental Status—A Comprehensive Review

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