Propolis: A useful agent on psychiatric and neurological disorders? A focus on CAPE and pinocembrin components

Silveira, Cinthia C S Menezes da; Luz, Diandra Araújo; Silva, Carla C S da; Prediger, Rui Daniel; Martins, Manoela Domingues; Fontes-Júnior, Enéas Andrade; Maia, Cristiane do Socorro Ferraz

doi:10.1002/med.21757

Cited by 20 publications

(18 citation statements)

References 76 publications

(124 reference statements)

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“…Propolis, a honeybee product, is a resinous product obtained from different plant parts mixed with beeswax and bee salivary enzymes and represents a multimillion dollar market [1,2]. It has been used in traditional medicine for many years due to its anti-microbial, anti-inflammatory, anti-oxidant, immunomodulator, anti-mutagenic, and carcinostatic effects [3].…”

Section: Introductionmentioning

confidence: 99%

CAPE and Neuroprotection: A Review

et al. 2021

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Propolis, a product of the honey bee, has been used in traditional medicine for many years. A hydrophobic bioactive polyphenolic ester, caffeic acid phenethyl ester (CAPE), is one of the most extensively investigated active components of propolis. Several studies have indicated that CAPE has a broad spectrum of pharmacological activities as anti-oxidant, anti-inflammatory, anti-viral, anti-fungal, anti-proliferative, and anti-neoplastic properties. This review largely describes CAPE neuroprotective effects in many different conditions and summarizes its molecular mechanisms of action. CAPE was found to have a neuroprotective effect on different neurodegenerative disorders. At the basis of these effects, CAPE has the ability to protect neurons from several underlying causes of various human neurologic diseases, such as oxidative stress, apoptosis dysregulation, and brain inflammation. CAPE can also protect the nervous system from some diseases which negatively affect it, such as diabetes, septic shock, and hepatic encephalopathy, while numerous studies have demonstrated the neuroprotective effects of CAPE against adverse reactions induced by different neurotoxic substances. The potential role of CAPE in protecting the central nervous system (CNS) from secondary injury following various CNS ischemic conditions and CAPE anti-cancer activity in CNS is also reviewed. The structure–activity relationship of CAPE synthetic derivatives is discussed as well.

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Section: Introductionmentioning

confidence: 99%

CAPE and Neuroprotection: A Review

et al. 2021

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“…Its color varies from yellowish green to dark brown, and odor from odorless to aromatic, and depends on its botanical source, origin of place, and bee characteristics such as strain and age [ 1 ]. Besides the structural and functional attributes of propolis for bees [ 2 ], it has been reported to possess a variety of therapeutic potentials for human use [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ] since ancient times. There are mainly two kinds of propolis known that differ in their constituents: New Zealand propolis possesses CAPE (Caffeic Acid Phenethyl Ester) and Brazilian green propolis that possesses Artepillin C (3,5-diprenyl-4-hydroxycinnamic acid, ARC) as pre-dominant bioactive compounds [ 10 , 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Molecular Insights into the Antistress Potentials of Brazilian Green Propolis Extract and Its Constituent Artepillin C

Kaul

Kuthethur

Ishida³

et al. 2021

Molecules

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Propolis, also known as bee-glue, is a resinous substance produced by honeybees from materials collected from plants they visit. It contains mixtures of wax and bee enzymes and is used by bees as a building material in their hives and by humans for different purposes in traditional healthcare practices. Although the composition of propolis has been shown to depend on its geographic location, climatic zone, and local flora; two largely studied types of propolis: (i) New Zealand and (ii) Brazilian green propolis have been shown to possess Caffeic Acid Phenethyl Ester (CAPE) and Artepillin C (ARC) as the main bioactive constituents, respectively. We have earlier reported that CAPE and ARC possess anticancer activities, mediated by abrogation of mortalin-p53 complex and reactivation of p53 tumor suppressor function. Like CAPE, Artepillin C (ARC) and the supercritical extract of green propolis (GPSE) showed potent anticancer activity. In this study, we recruited low doses of GPSE and ARC (that did not affect either cancer cell proliferation or migration) to investigate their antistress potential using in vitro cell based assays. We report that both GPSE and ARC have the capability to disaggregate metal- and heat-induced aggregated proteins. Metal-induced aggregation of GFP was reduced by fourfold in GPSE- as well as ARC-treated cells. Similarly, whereas heat-induced misfolding of luciferase protein showed 80% loss of activity, the cells treated with either GPSE or ARC showed 60–80% recovery. Furthermore, we demonstrate their pro-hypoxia (marked by the upregulation of HIF-1α) and neuro-differentiation (marked by differentiation morphology and upregulation of expression of GFAP, β-tubulin III, and MAP2). Both GPSE and ARC also offered significant protection against oxidative stress and, hence, may be useful in the treatment of old age-related brain pathologies.

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“…Furthermore, Takeda et al showed that caffeic acid possesses antidepressive properties in a mice model of depression, reducing the duration of immobility in the forced swimming test. They also demonstrated that caffeic acid reversed the depression-related reduced BDNF (da Silveira et al, 2021;Takeda et al, 2006). Mehrotra et al reported the protective effects of caffeic acid against inflammatory pain by averting the production of myeloperoxidase, malondialdehyde nitrite, and a drop in neutrophil infiltration in the inflamed tissue (Mehrotra, Shanbhag, Chamallamudi, Singh, & Mudgal, 2011).…”

Section: Discussionmentioning

confidence: 96%

Propolis add‐on therapy alleviates depressive symptoms; A randomized placebo‐controlled clinical trial

Varzaghani

Sharifi

Hajiaghaee

et al. 2022

Phytotherapy Research

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Almost half of the treatments with common antidepressants are failed or result in a relapse of symptoms after cessation. Moreover, the antidepressants side effects rationalize the use of complementary medicine as an adjunctive therapy. This study aimed to evaluate the efficacy and safety of propolis in complementary therapy of depressive disorder. Chromatography technics were used to detect propolis components. A double-blind, randomized, placebo-controlled trial was designed, and 54 participants were randomly assigned to receive either propolis or Placebo for 6 weeks.Treatment was defined as a decrease in 17-item Hamilton Depression Scale (HAMD-17) and Beck depression inventory (BDI). On D42, there was a significant reduction in HAMD score in the propolis group compared with the placebo group (p < .0001).HAMD score significantly decreased in the propolis group from 20.92 ± 3.77 on D0 to 10.03 ± 5.55 on D42, and BDI score was improved from 29.25 ± 3.06 on D0 to 14.17 ± 4.86 on D42. Our findings confirmed that complementary treatment of propolis with SSRIs could safely attenuate symptoms of moderate-severe MDD. These antidepressant effects might result from the rich phenolic acids and flavonoids content of Azerbaijan propolis.

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Propolis: A useful agent on psychiatric and neurological disorders? A focus on CAPE and pinocembrin components

Cited by 20 publications

References 76 publications

CAPE and Neuroprotection: A Review

CAPE and Neuroprotection: A Review

Molecular Insights into the Antistress Potentials of Brazilian Green Propolis Extract and Its Constituent Artepillin C

Propolis add‐on therapy alleviates depressive symptoms; A randomized placebo‐controlled clinical trial

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