Propofol Sedation for Endoscopic Procedures in Children

Elitsur, Yoram; Blankenship, Penny; Lawrence, Zoe

doi:10.1055/s-2000-7713

Cited by 84 publications

(67 citation statements)

References 13 publications

(14 reference statements)

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“…We are fully aware that we only measured reported memory, not visual and verbal memory recall, but the results of our study are similar to other evaluating procedural memory after endoscopy [7,9].…”

Section: Strengths and Limitationssupporting

confidence: 88%

“…Recently published systematic review on method of sedation and anaesthesia in children showed that PF provide maximal patient comfort with effectiveness comparable to general anaesthesia, in particular, if it is preceded by midazolam premedication [4]. Observational studies performed in children sedated with midazolam showed that approximately 20 % of patients reported some memory of the EGD whereas anaesthesia with propofol resulted in loss of procedural memory in almost all patients [1,7,9]. One of these studies also showed that anaesthesia with PF was associated with the need for restraint in only 3 % of cases, compared with 57 % in the midazolam group which is similar to our trial.…”

Section: Comparison To Other Studiesmentioning

confidence: 99%

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Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children—blind randomised trial

et al. 2015

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Section: Strengths and Limitationssupporting

confidence: 88%

Section: Comparison To Other Studiesmentioning

confidence: 99%

Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children—blind randomised trial

et al. 2015

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“…With growing evidence supporting its use in both adults and children [16, 17, 18, 19, 20, 21, 22, 23]propofol now stands at the threshold of a broad introduction into the endoscopy suite. Today, three major questions regarding its use have to be answered:…”

Section: Introductionmentioning

confidence: 99%

The Dawning of a New Sedative: Propofol in Gastrointestinal Endoscopy

Heuss

Inauen²

2004

Digestion

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Background: Using gentler endoscopes and improved sedation, great strides have been made in enhancing patients’ comfort and acceptance of endoscopic procedures. Because morbidity and mortality have been associated with benzodiazepines in endoscopic sedation, safer alternatives were sought. Propofol (2,6-diisopropylphenol), a rapid and short-acting anesthetic, initially used in the 1980’s for general anesthesia induction and maintenance, is a promising candidate. Methods: This review article examines experiences and literature references of propofol’s use in endoscopic procedures. Three critical questions are posed: What are the major advantages and potential risks of propofol? When should propofol be used? Who should administer propofol, how should it be administered, and what type of monitoring is required? Results: With considerable inter-patient variability, the propofol dose must be carefully titrated according to the individual patient’s response. Factors influencing dosage include age, ASA class, patient’s height and procedure duration. Propofol’s primary risk is its narrow therapeutic range which necessitates careful patient monitoring. Conclusions: Propofol’s advantages over benzodiazepines and narcotics include a more rapid onset of action, full relief of discomfort and rapid recovery to alertness without residual sedative effects or anterograde amnesia, thereby making this drug a cost-effective and, with proper monitoring, safe choice.

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“…Other goals are to maximize efficiency and contain costs [49]. The method of sedation is a matter of choice after careful consideration of a number of factors including the patient's condition, ASA classification, the type of procedure, the parents' and patient's preference, and the level of cooperation of the patientWith proper patient selection, intravenous sedation is a safe and effective method for sedation in pediatric endoscopy [50,51]. General anesthesia should be considered necessary for highly complicated procedures and for patients at high risk for cardiovascular complications.…”

Section: Pediatric Endoscopymentioning

confidence: 99%

Sedation for Esophagogastroduodenal Endoscopy

Aydın¹

2011

Ann Clin Anal Med

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ÖzetÖzefagogastroduedonal endoskopi sırasında pek çok anestetik yöntem ve ilaç kullanılabilir. Özefagogastroduedonal endoskopi için uygulanacak sedasyon ilaç ve yöntemleri hakkında araştırmalar sürmektedir. Bu derlemenin amacı sedasyon ve özefagogastroduedonal endoskopi ve sedasyonla ilişkili konuları literature bilgileri ışığında tartışmaktır. Tanısal özefagogastroduedonal endoskopi için günü-müzde kullanılan standart yöntem genellikle yüzeyel farengeal anestezi minimal sedasyon ya da anksiyolizdir. Gerekli olursa sonradan analjezi eklenebilir. Uzun süreli, karmaşık ya da sorunlu ve ağrılı işlemler için uzman denetiminde yapılan daha derin sedasyon yöntemleri gerekebilir. Anahtar KelimelerEndoskopi; Gastrointestinal Endoskopi; Sedasyon Abstract Different anesthetic techniques and drugs can be used for esophagogastroduedonal endoscopy. However, the scientists are still searching for appropriate drugs and protocols for sedation during esophagogastroduedonal endoscopy. The aim of this review is to discuss the topics related with sedation and esophagogastroduedonal endoscopy in the light of literature. Today standard procedure for diagnostic esophagogastroduedonal endoscopy usually consists of topical pharyngeal anesthesia, minimal sedation or anxiolysis, which may be complemented with analgesia when needed. When a prolonged, complex, or particularly troublesome or painful examination is foreseen, deeper sedation with multiple drugs and in closed observation of a staff may be required.

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Propofol Sedation for Endoscopic Procedures in Children

Abstract: Propofol sedation for endoscopic procedures is safe and acceptable for children. Propofol sedation should be offered to young children, especially those who express significant anxiety.

Cited by 84 publications

References 13 publications

Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children—blind randomised trial

Propofol-alfentanyl versus midazolam-alfentanyl in inducing procedural amnesia of upper gastrointestinal endoscopy in children—blind randomised trial

The Dawning of a New Sedative: Propofol in Gastrointestinal Endoscopy

Sedation for Esophagogastroduodenal Endoscopy

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