Propofol-Related Infusion Syndrome: Role of Propofol in Medical Complications of Sedated Critical Care Patients

Investigation into Drug Solubilisation Potential of Sulfonated Calix[4]Resorcinarenes

“…Despite the market success of propofol emulsions, the concomitant use of painkillers and antimicrobial agents are required due to its viscosity causing pain on administration and the high infection risk [28]. Additionally, hyperlipidemia, rhabdomyosis and metabolic acidosis have been reported and linked to propofol-fat parental emulsions (propofol-Related Infusion Syndrome) [29]. Griseofulvin ((2S)-trans-7-chloro-2',4,6-trimethoxy 6'-methylspiro(benzofuran-2[3H],1'- [2] cyclohexene)3,4'-dione) (Figure 2c) is an orally administered antifungal agent, used for the treatment of dermatophytoses.…”

Insuficiencia cardíaca aguda tras administración de propofol y fentanilo en pacientes sin enfermedad cardíaca estructural: reporte de dos casos

“…La utilidad de monitorizar creatinquinasa ha sido cuestionada y la hipertrigliceridemia puede ocurrir en pacientes sanos luego de varias horas. A pesar de ello, el Colegio Americano de Cuidado de Medicina Crítica recomienda medir el nivel de triglicéridos después de 48 horas de iniciada la infusión, el comité europeo monitorizar en búsqueda de acidosis metabólica, rabdomiolisis, hiperkaliemia y disfunción cardiaca [16,28].…”

Propofol infusion syndrome

“…6 Its rapid onset and elimination allow for quick weaning and neurologic assessments. 9 It occurred most frequently after 48 to 72 hours of infusion. 7 In a large prospective study conducted in 2008, 1,017 patients from 11 ICUs who were suspected of having PRIS were observed.…”

“…7 Its anesthetic properties are thought to stem from its inhibition of the gamma-aminobutyric acid receptor, which also makes it effective for seizure suppression. 9 Case reports have described PRIS in patients undergoing burst suppression for RSE who received a high-dose propofol infusion or a large cumulative dose. The inclusion criteria for PRIS were continuous propofol infusion followed by development of metabolic acidosis and cardiac dysrhythmia with the addition of rhabdomyolysis, hypertriglyceridemia, or renal failure.…”

“…16 Besides using alternative methods of sedation, 9 preventive measures include infusing the lowest dose of propofol for the shortest duration, minimizing lipid load (concentrating propofol drip and adjusting parenteral nutrition), providing adequate carbohydrate intake, and stopping the propofol infusion at the earliest signs of abnormal lab results and/or ECG changes. An algorithm for preventing PRIS has been proposed but hasn't been studied in clinical trials.…”