Propofol plus low-dose dexmedetomidine infusion and postoperative delirium in older patients undergoing cardiac surgery

Momeni, Mona; Khalifa, Céline; Lemaire, Guillaume; Watremez, Christine; Tircoveanu, Robert; Dyck, Michel Van; Kahn, David; Martins, Maria Rosal; Mastrobuoni, Stefano; Kerchove, Laurent de; Zango, Serge Henri; Jacquet, Luc‐Marie

doi:10.1016/j.bja.2020.10.041

Cited by 41 publications

(43 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dexmedetomidine has the advantages of sensory block and analgesia. On the one hand, due to its effect at the spinal cord level, it inhibits the release of norepinephrine and blocks the transmission of pain signals to the brain by acting on A2 receptors in the presynaptic membrane and posterior membrane of the spinal cord [ 29 ]. On the other hand, due to its effect on the A2 receptor of the cerebral vena cava, it inhibits the excitation of the neurons in the vena cava and blocks the pain nerve signal transduction pathway of the medullary globus-spinal cord to achieve sedation and analgesia [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

The Anesthetic Effect and Safety of Dexmedetomidine in Cesarean Section: A Meta-Analysis

Pang

Zhu

Yan

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Objective. To evaluate the anesthetic effect and safety of dexmedetomidine in cesarean section. Methods. The Cochrane Library, EMBASE, and PubMed databases (established until September 2020) were searched by computer. Two authors independently screened and extracted literature related to the application of dexmedetomidine in the cesarean section according to inclusion and exclusion criteria. The control group received either subarachnoid block (lumbar anesthesia) or combined lumbar anesthesia and epidural anesthesia (combined lumbar epidural anesthesia) with bupivacaine or combined bupivacaine and fentanyl. The observation group was additionally given dexmedetomidine based on the control group, to analyze the anesthetic effect and safety of dexmedetomidine in cesarean section. Results. A total of 580 cesarean delivery women were included in 8 studies, and the results showed that the peak time of sensory block in the observation group was shorter than that in the control group (standard mean difference = − 0.28 ; 95% confidence interval: -0.48, -0.08; P = 0.006 ), sensory block lasted longer than that in the control group (standard mean difference = 1.49 ; 95% confidence interval: 1.21, 1.78; P < 0.00001 ), the sedation rate was higher than that in the control group, the onset of the first postoperative pain was significantly delayed compared with that in the control group, and the incidence of postoperative pain, nausea and vomiting, postoperative chills, and fever was lower than that in the control group ( P < 0.05 ). Conclusion. Dexmedetomidine combined with lumbar anesthesia or combined lumbar epidural anesthesia for women in cesarean section has more clinical benefits and better safety.

show abstract

Section: Discussionmentioning

confidence: 99%

The Anesthetic Effect and Safety of Dexmedetomidine in Cesarean Section: A Meta-Analysis

Pang

Zhu

Yan

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The dose of DEX may affect the anesthesia time, the postoperative eye-opening time, and the extubation time [ 18 , 19 ]. It is further suggested that DEX has a highly selective excitatory effect on α 2 adrenalin receptors in the locus coeruleus of the brain and can effectively inhibit the discharge function of neurons, thus exerting analgesic and sedative effects.…”

Section: Related Workmentioning

confidence: 99%

[Retracted] Effects of Dexmedetomidine on Hemodynamics and Anesthesia Effect of Different Doses of General Anesthesia in Patients Undergoing Hepatobiliary Surgery

Xue

et al. 2022

Contrast Media & Molecular Imaging

View full text Add to dashboard Cite

In order to provide corresponding anesthesia methods of hepatobiliary diseases and obtain better clinical effect, the hemodynamics and clinical efficacy are evaluated by using different doses of dexamethasone (DEX) during the operation. 97 patients undergoing general anesthesia for hepatobiliary surgery in our hospital from April 2020 to August 2021 are analyzed retrospectively. All patients are divided into G1 (n = 24), G2 (n = 24), G3 (n = 24), and control group (n = 25) according to the random number table method. The G1, G2, and G3 groups are injected with DEX 1.0 ug/kg, DEX 0.8 ug/kg, and DEX 0.5 ug/kg by intravenous infusion pump before induction of general anesthesia, and the control group is injected with 0.9%Nacl solution 10 mL. Intraoperative anesthesia time, postoperative eye opening time, and extubation time of all groups are observed, and the incidences of postoperative adverse reactions are compared. The experimental results show that during general anesthesia in the liver and gallbladder surgery, the patients with high dose of DEX can better maintain the intraoperative hemodynamic parameters, and effectively restrain the postoperative stress reaction.

show abstract

“…16e19 Older trials of dexmedetomidine in this population did not examine delirium as the primary outcome, further limiting the quality of conclusions drawn. 20e23 Since the previous systematic reviews were published, several large trials have been conducted evaluating postoperative delirium as their primary outcome measure, 11,12,24 and those trials have the potential to add significant weight and quality to the available evidence base.…”

mentioning

confidence: 99%

Influence of perioperative dexmedetomidine on the incidence of postoperative delirium in adult patients undergoing cardiac surgery

Patel¹,

Onwochei²,

Desai³

2022

British Journal of Anaesthesia

View full text Add to dashboard Cite

Propofol plus low-dose dexmedetomidine infusion and postoperative delirium in older patients undergoing cardiac surgery

Cited by 41 publications

References 30 publications

The Anesthetic Effect and Safety of Dexmedetomidine in Cesarean Section: A Meta-Analysis

The Anesthetic Effect and Safety of Dexmedetomidine in Cesarean Section: A Meta-Analysis

[Retracted] Effects of Dexmedetomidine on Hemodynamics and Anesthesia Effect of Different Doses of General Anesthesia in Patients Undergoing Hepatobiliary Surgery

Influence of perioperative dexmedetomidine on the incidence of postoperative delirium in adult patients undergoing cardiac surgery

Contact Info

Product

Resources

About