Propofol or Thiopentone: Effects on Intraocular Pressure Associated With Induction of Anaesthesia and Tracheal Intubation (Facilitated With Suxamethonium)

Abstract

Changes in intraocular pressure (IOP) were studied in patients given propofol 2.1 mg kg-1 (n = 30) or thiopentone 4.9 mg kg-1 (n = 30) followed by suxamethonium 1.0 mg kg-1 and tracheal intubation. Half the patients in each group received an additional smaller dose of the same induction agent (propofol 1.0 mg kg-1 or thiopentone 2.0 mg kg-1) immediately before intubation. Both agents produced significant decreases in IOP which were slightly more marked with propofol. The administration of suxamethonium produced an increase in IOP in all groups, more so in those given thiopentone, in whom it exceeded the control values. Intubation of the trachea produced the greatest increase in IOP, averaging about 25% above control in all groups except in the group given the additional dose of propofol, in whom IOP remained below control values throughout the process of induction and intubation. Ten patients (33%) experienced pain on injection with propofol. A decrease in systolic arterial pressure of more than 30% was observed in 12 patients (40%) receiving propofol, compared with three (10%) of those given thiopentone.

Influence of dexmedetomidine-propofol-isoflurane and medetomidine-propofol-isoflurane on intraocular pressure and pupil size in healthy dogs

“…However, the insignificant IOP changes after propofol administration observed in the present study were probably due to the lower dose of doi: 10.17221/115/2016-VETMED propofol used. Our and Hofmeister's findings are not in agreement with those reported in humans, where propofol decreased IOP by 40% (Mirakhur et al 1987).…”

Intraocular Pressure Variations during Zygomatic Fracture Reduction and Fixation: A Clinical Study

“…39 Induction agents (e.g., propofol) cause a decrease in the pressures of up to 40 percent. 40 It is possible that the low pressures recorded in both the control and operated sides in six patients were related to the propofol used as the induction agent in all patients in this study.…”

Comparison of intraocular tonometry using three different non-invasive tonometers in children

“…There are two other parameters potentially influencing IOP measurements, namely body position [15] and the influence of anaesthesia [22][23][24]. We believe both to be irrelevant in our investigation, as all our measurements [3] recently demonstrated that the IOP decreased significantly during the first 8 minutes of general anaesthesia in children.…”