Propofol-Induced Priapism, a Case Confirmed with Rechallenge

Vesta, Kimi S.; Martina, Shaunta' D; Kozlowski, Ellen A

doi:10.1345/aph.1g555

Cited by 27 publications

(24 citation statements)

References 12 publications

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“…They suggested a dose dependant vasodilation as the possible mechanism. 18 In the treatment of this condition, cessation of all stimuli may help to achieve detumescence. In one of our patients, detumescence occurred within 15 minutes with masterly inactivity only.…”

Section: Discussionmentioning

confidence: 99%

Intracavernosal Use of Adrenalin to Interrupt Anaesthetic Penile Erection During Transurethral Surgery

Bansal¹,

Gupta²

2016

jemds

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BACKGROUND AND OBJECTIVESIntraoperative penile erection is uncommon, but troublesome problem associated with anaesthesia in patients undergoing transurethral surgery. Many methods and drugs have been used in past to solve this problem. Our objective was to find the incidence of intraoperative penile erection and to study the use of intracavernosal injection of adrenalin to solve this problem. Adrenalin is a strong sympathomimetic and an essentially present drug in the operation theatre besides being cheaper.

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Section: Discussionmentioning

confidence: 99%

Intracavernosal Use of Adrenalin to Interrupt Anaesthetic Penile Erection During Transurethral Surgery

Bansal¹,

Gupta²

2016

jemds

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“…Vesta[3] and coworkers confirmed a strong association of propofol to priapism with rechallenge. They also established the dose-response relationship.…”

Section: Discussionmentioning

confidence: 99%

“…Propofol has been reported to cause sexual hallucinations during and after sedation, but priapism was documented rarely in some individuals earlier. [34] Propofol-induced priapism in a healthy male is reported herein, the first one in the Indian literature.…”

Section: Introductionmentioning

confidence: 89%

Propofol and priapism

et al. 2010

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Propofol-induced priapism in a 25-year-old male confirmed by rechallenge is reported for its rarity and to create awareness among practitioners, because propofol is used frequently in India for the induction and maintenance of anesthesia or sedation. The probable mechanisms are highlighted. Because propofol causes low-flow priapism, early alleviation is essential to minimize and/or avert the long-term complications.

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“…To our knowledge, only 3 cases of this rare side effect have been reported, 2 of which were in children. [2][3][4] Case Report A 13-year-old white male with a history of global developmental delay, tracheostomy-dependent respiratory failure, and intermittent choreoathetosis was admitted to the PICU with respiratory distress secondary to pneumonia and persistent paroxysmal choreoathetoid movements.…”

Section: Introductionmentioning

confidence: 99%

Propofol-Associated Priapism in a Pediatric Patient

Doherty

Khandhar

2014

Journal of Pharmacy Technology

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Objective: To report a case of priapism in an adolescent male following the use of propofol for sedation. Case Report: A 13-year-old male with developmental delay was admitted to intensive care secondary to pneumonia and persistent paroxysmal choreoathetosis. In attempt to stop the choreoathetosis and progressive rhabdomyolysis, he was sedated with 50 mg of intravenous propofol, which successfully resolved the choreoathetosis. Within minutes after the injection, he developed priapism, and within 1 hour it resolved without intervention. Discussion: Priapism was considered to be caused by propofol based on temporal relationship, lack of other medications administered, and complete resolution of symptoms after withdrawal. An objective causality assessment based on the Naranjo adverse drug reaction probability scale suggests propofol is a probable cause of the priapism in our patient. The mechanism of propofol-induced priapism is unknown but likely occurs due to both local and systemic effects. Conclusion: Pediatric clinicians should be aware of this rare side effect, as it requires prompt recognition and potential urologic intervention to alleviate complications.

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Propofol-Induced Priapism, a Case Confirmed with Rechallenge

Abstract: Although, as of April 4, 2006, this adverse effect has not been previously reported, there is a strong correlation of propofol to priapism in this patient. Clinicians should be aware of this adverse effect.

Cited by 27 publications

References 12 publications

Intracavernosal Use of Adrenalin to Interrupt Anaesthetic Penile Erection During Transurethral Surgery

Intracavernosal Use of Adrenalin to Interrupt Anaesthetic Penile Erection During Transurethral Surgery

Propofol and priapism

Propofol-Associated Priapism in a Pediatric Patient

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