Propofol-induced loss of consciousness is associated with a decrease in thalamocortical connectivity in humans

Abstract

It is unclear how anaesthesia affects activity across brain networks. Using local field potentials recorded directly from the ventral intermediate nucleus of the thalamus and frontoparietal cortex in patients undergoing DBS surgery, Malekmohammadi et al. report the breakdown of α functional thalamocortical connectivity under propofol anaesthesia despite local power increases.

Lead Repositioning Guided by Both Physiology and Atlas Based Targeting in Tourette Deep Brain Stimulation

“…Similarly, a strong PAC between the depth electrode (phase) and the subdural strip (amplitude) was observed ( Figure 2B). Malekmohammadi et al [13] and our group have both shown the presence of PAC between the VIM and M1 [19]. This PAC was not a feature observed in the three other TS patients recruited into the study.…”

Electroencephalogram Dynamics of Etomidate-Induced Loss of Consciousness

“…At present, in the induction of clinical anesthesia, the determination of the loss of consciousness is assessed by aimless movements after harmful stimulation [14]. In the present study, the auditory stimulation assessment [15,16] was supplemented by the disappearance of the eyelash re ex to con rm the loss of consciousness. Before inducing anesthesia, we instructed patients not to open or move their eyes.…”

Electroencephalographic dynamics of etomidate‐induced loss of consciousness

“…At present, in the induction of clinical anesthesia, the determination of the LOC is assessed by aimless movements after harmful stimulation [ 13 ]. In the present study, the auditory stimulation assessment [ 14 , 15 ] was supplemented by the disappearance of the eyelash reflex to confirm the LOC. Before inducing anesthesia, we instructed patients not to open or move their eyes.…”