Propofol-induced anaphylactoid reaction during anesthesia for cardiac surgery

Ducart, Anne; Watremez, Christine; Louagie, Yves; Collard, Édith; Broka, Serge M.; Joucken, Kurt

doi:10.1016/s1053-0770(00)90020-x

Cited by 15 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The authors concluded that it was due to the isopropyl or phenyl group, rather than the intralipid emulsion, in these cases. This is also supported by other reports of patients without food allergies reacting to propofol . Recently there have been cases of allergy to ethylenediamine tetra‐acetic acid (EDTA), another excipient in propofol .…”

Section: Discussionsupporting

confidence: 72%

Propofol use in children with allergies to egg, peanut, soybean or other legumes

et al. 2019

View full text Add to dashboard Cite

Summary Propofol is the most commonly administered intravenous agent for anaesthesia in children. However, there are concerns that the emulsified preparation may not be safe in children with an allergy to egg, peanut, soybean or other legumes. We conducted a retrospective study of children with immunologically confirmed egg, peanut, soybean or legume allergy and who underwent general anaesthesia at Princess Margaret Hospital for Children between 2005 and 2015. We extracted details regarding allergy diagnosis, each anaesthetic administered and any adverse events or signs of an allergic reaction in the peri‐operative period. A convenience sample of patients without any known food allergies was identified from our prospective anaesthesia research database and acted as a control group. We identified 304 food‐allergic children and 649 procedures where propofol was administered. Of these, 201 (66%) had an egg allergy, 226 (74%) had a peanut allergy, 28 (9%) had a soybean allergy and 12 (4%) had a legume allergy. These were compared with 892 allergy‐free patients who were exposed to propofol. In 10 (3%) allergy patients and 124 (14%) allergy‐free patients, criteria for a possible allergic reaction were met. In nine of the food‐allergic children and in all the controls valid non‐allergic explanations for the clinical symptoms were found. One likely mild allergic reaction was experienced by a child with a previous history of intralipid allergy. We conclude that genuine serious allergic reaction to propofol is rare and is not reliably predicted by a history of food allergy.

show abstract

Section: Discussionsupporting

confidence: 72%

Propofol use in children with allergies to egg, peanut, soybean or other legumes

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Specific IgE to propofol occurs, but most propofol reactions are due to direct mast cell activation. 138 Narcotics used in anesthesia commonly cause flushing and urticaria after intravenous administration. The risk of anaphylaxis or anaphylactoid reactions, in contrast, is very rare.…”

Section: Anaphylaxis During General Anesthesia the Intraoperative Pementioning

confidence: 99%

The diagnosis and management of anaphylaxis: An updated practice parameter

Lieberman¹,

Kemp²,

Oppenheimer³

et al. 2005

Journal of Allergy and Clinical Immunology

459

254

View full text Add to dashboard Cite

“…A total of 404 upper endoscopies were performed under propofol sedation (401 under endoscopist supervision and three under general anesthesia). Mean number of upper endoscopies was 6.9 per patient , and median propofol dose used in each procedure was 174 mg (range: 62–284). No anaphylactic or allergic adverse events were reported, except a bronchospasm episode after orotracheal intubation in an asthmatic 14‐year‐old boy.…”

Section: Resultsmentioning

confidence: 99%

“…This emulsion was specifically designed to avoid allergic reactions in egg‐ or soy‐allergic patients, considering that soybean oil is highly refined with almost nonallergenic content after the refining process and egg lecithin comes from egg yolk, being the most allergenic proteins contained in egg white . Over the last 25 years, several cases of anaphylaxis or allergic adverse events after propofol administration have been reported , presumably related in most cases to cross‐reactivity with food allergies.…”

mentioning

confidence: 99%