Abstract:Background Propofol is a widely used anesthetic and sedative, which has been reported to exert an antiin ammatory effect. TLR4 plays a critical role in coordinating the immuno-in ammatory response during sepsis. Whether propofol can act as an immunomodulator through regulating TLR4 are still unclear. In view of its potential as a sepsis therapy, we investigated the mechanisms underlying the immunomodulatory activity of propofol.Methods: The effects of propofol on TLR4 and Rab5a (a master regulator involved in … Show more
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