Propofol for tracheal intubation in children anesthetized with sevoflurane: a dose–response study

Abstract

During sevoflurane/nitrous oxide anesthesia, propofol 3 mg x kg(-1) provides superior intubating conditions with an increased incidence of and prolonged apnea compared with 0 and 0.5 mg x kg(-1).

Çocuklarda kas gevşeticisiz trakeal entübasyon

“…Lerman ve ark. (24), yaptığı çalışmada dengeli olarak iki ajanı kullanmış ve buna kanıt olarak sevoflurane konsantrasyonunun %3.7'lerde tutarak propofol dozunu 3 mg/kg uygulamışlar %90 mükemmel entübasyon koşulu sağlayabilmişlerdir.…”

Comparaison de deux doses de propofol pour l’intubation trachéale chez l’enfant

“…Peu d'articles publiés avaient comparé deux doses de propofol pour l'induction chez l'enfant [8]. En effet, la littérature regorge plutôt de protocoles associant le propofol, soit à des adjuvants morphiniques à doses variables [9,10], soit à d'autres hypnotiques essentiellement le sévoflurane [11]. Le point en commun à toutes ces études est le critère de jugement principal : assurer des conditions d'intubation optimales en utilisant divers scores d'évaluation.…”

Selection of Anesthesia Techniques for the Neonate

“…Both positive end-expiratory pressure (10 cmH 2 O) and assisted ventilation speed the rapid onset of a deep level of anesthesia [ 179 ]. Alternately, the time to tracheal intubation may be abbreviated by supplementing the inhalational induction with IV drugs such as propofol, opioids, and muscle relaxants [ 180 ]. These strategies have been studied in children and likely may be extended to neonates, although evidence in neonates remains lacking.…”

“…In neonates, the time to induce anesthesia is rapid; however, with a MAC of 3.2 % sevofl urane, the maximum MAC multiple that can be achieved within the fi rst minute or two of anesthesia is only 1.2 (unlike halothane which can achieve a MAC multiple of 2.5 within the same time) (see Pharmacology chapter). Hence, to speed the induction of deep anesthesia, an IV dose of 2-3 mg/kg propofol may be administered [ 180 ].…”