“…During sedation with propofol, regionally diverse, dose-dependent changes in resting-state connectivity have been found (Hudetz, 2012;Liu et al, 2013d). In particular, a breakdown of functional or effective connectivity has been demonstrated with both fMRI and electrophysiological methods (Boveroux et al, 2010;Ferrarelli et al, 2010;Gomez et al, 2013;Lee et al, 2009a;Liu et al, 2012;Schrouff et al, 2011). Functional connectivity changes in both thalamocortical (Alkire et al, 2000;Liu et al, 2013c;White and Alkire, 2003) and corticocortical networks (Alkire and Miller, 2005;Boly et al, 2012;Boveroux et al, 2010;Ferrarelli et al, 2010;Hudetz, 2012;Schrouff et al, 2011;Soddu et al, 2012) have been detected.…”