2011
DOI: 10.1002/hbm.21385
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Propofol disrupts functional interactions between sensory and high‐order processing of auditory verbal memory

Abstract: Current theories suggest that disrupting cortical information integration may account for the mechanism of general anesthesia in suppressing consciousness. Human cognitive operations take place in hierarchically structured neural organizations in the brain. The process of low-order neural representation of sensory stimuli becoming integrated in high-order cortices is also known as cognitive binding. Combining neuroimaging, cognitive neuroscience, and anesthetic manipulation, we examined how cognitive networks … Show more

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Cited by 116 publications
(120 citation statements)
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“…During sedation with propofol, regionally diverse, dose-dependent changes in resting-state connectivity have been found (Hudetz, 2012;Liu et al, 2013d). In particular, a breakdown of functional or effective connectivity has been demonstrated with both fMRI and electrophysiological methods (Boveroux et al, 2010;Ferrarelli et al, 2010;Gomez et al, 2013;Lee et al, 2009a;Liu et al, 2012;Schrouff et al, 2011). Functional connectivity changes in both thalamocortical (Alkire et al, 2000;Liu et al, 2013c;White and Alkire, 2003) and corticocortical networks (Alkire and Miller, 2005;Boly et al, 2012;Boveroux et al, 2010;Ferrarelli et al, 2010;Hudetz, 2012;Schrouff et al, 2011;Soddu et al, 2012) have been detected.…”
Section: Discussionmentioning
confidence: 99%
“…During sedation with propofol, regionally diverse, dose-dependent changes in resting-state connectivity have been found (Hudetz, 2012;Liu et al, 2013d). In particular, a breakdown of functional or effective connectivity has been demonstrated with both fMRI and electrophysiological methods (Boveroux et al, 2010;Ferrarelli et al, 2010;Gomez et al, 2013;Lee et al, 2009a;Liu et al, 2012;Schrouff et al, 2011). Functional connectivity changes in both thalamocortical (Alkire et al, 2000;Liu et al, 2013c;White and Alkire, 2003) and corticocortical networks (Alkire and Miller, 2005;Boly et al, 2012;Boveroux et al, 2010;Ferrarelli et al, 2010;Hudetz, 2012;Schrouff et al, 2011;Soddu et al, 2012) have been detected.…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, regaining consciousness may depend on the restoration of the brain's state repertoire and the interaction of its units. There is experimental evidence for reduced functional integration in large-scale systems under general anesthesia 32-35 but corresponding data in neuronal populations have not been obtained to-date.…”
Section: Discussionmentioning
confidence: 99%
“…Deep sedation was defined as absent responsiveness to verbal commands. Data are from seven volunteers (Liu et al, 2012b). Note the substantial and reversible reduction of nonspecific thalamocortical connectivity during deep sedation (Figure by the courtesy of Dr. Xiaolin Liu).…”
Section: Regaining Consciousness Has Unique Neural Correlatesmentioning
confidence: 99%