Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock

Basu, Samar; Mutschler, D; Larsson, Anders; Kiiski, Ritva; Nordgren, Anders; Eriksson, Mats

doi:10.1016/s0300-9572(01)00351-3

Cited by 53 publications

(37 citation statements)

References 23 publications

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“…Unwanted complication associated with this drug is hemodynamic instability and cardiovascular complications. Propofol can lead to bradycardia by increasing the production and release of nitrous oxide [4][5][6]. Also causes pain at injection site.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study of Effect of Propofol, Etomidate and Propofol Plus Etomidate Induction on Hemodynamic Response to Endotracheal Intubation: A RCT

Meena¹,

Meena²,

Nayak³

et al. 2016

J Anesth Clin Res

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Objective: The primary objective of this study was to compare the efficacy of 3 different anesthesia induction approach (Inj. Propofol, Inj. Etomidate and Inj. propofol plus Inj Etomidate) in maintaining hemodynamic stability during induction and following endotracheal intubation in elective surgery. Material and method:Ethical committee clearance taken, 90 patients aged 15 to 60 years of either sex and ASA physical status I or II scheduled for elective surgery under general anesthesia were taken for study. Written and informed consent was taken. The patients were randomly placed into three groups. Group I induced with Inj. Propofol (2.5 mg/kg) intravenous, Group II with Inj. Etomidate (0.3 mg/kg) intravenous and Group III with Inj. Propofol (1 mg/kg) plus Inj. Etomidate (0.2 mg/kg) intravenous. Heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP) and oxygen saturation (SPO 2 ) were noted at different time interval.Results: Heart rate in all study groups decreases after induction and it was more in group I compared to group II and III (p<0.000) and after intubation HR increases in all three groups but this increase is greater in group II than other two groups. MAP among all three groups decreases after induction and it was more in group I than group II and III. Significant increase in MAP was seen at 1 min after intubation in all three groups but this increase was not sustained and returned to baseline in group II and III. Conclusion:The combination of etomidate plus propofol has better hemodynamic stability than etomidate alone at 1 min after intubation, though etomidate was equally stable at other points of time. The combination proved to be significantly better than either propofol or etomidate alone.

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Section: Introductionmentioning

confidence: 99%

A Comparative Study of Effect of Propofol, Etomidate and Propofol Plus Etomidate Induction on Hemodynamic Response to Endotracheal Intubation: A RCT

Meena¹,

Meena²,

Nayak³

et al. 2016

J Anesth Clin Res

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“…Reactive nitrogen species were nitric oxide and peroxynitrite (Brasil et al, 2006). The production of these free radicals was favoured directly by reduced perfusion and tissue anoxia and indirectly by anaesthetic and ancillary drugs (Basu et al, 2001 andOzer andKaman, 2007). The free radicals were released from cytochrome P450, endothelium, granulocytes, macrophages and red blood corpuscles.…”

Section: Antioxidantsmentioning

confidence: 99%

“…Oxidative stress occurred when the production of oxygen free radicals (RSO = Reactive oxygen species) and nitric oxide radicals (NOR) exceeded the scavenging capacity of systemic endogenic antioxidants through enzymatic and non enzymatic pathways (Basu et al, 2001 The reactive oxygen species were hydrogen peroxide, superoxide anion, peroxide radicals, alkoxy radical and peroxy radical. Reactive nitrogen species were nitric oxide and peroxynitrite (Brasil et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

“…Reactive nitrogen species were nitric oxide and peroxynitrite (Brasil et al, 2006). The production of these free radicals was favoured directly by reduced perfusion and tissue anoxia and indirectly by anaesthetic and ancillary drugs (Basu et al, 2001 andOzer andKaman, 2007). Free radicals induce stress, inflammation, delay in wound healing, prolonged recovery from anaesthesia and post anaesthetic complications due to the impact on the functional ability of heart, lung, spleen, liver, kidney, red blood corpuscles and muscles (Brasil et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress response of guaifenesin-ketamine anaesthetized cattle during surgery under detomidine/xylazine premedication

Gnanasekar¹,

Ramshankar²

2016

Int. J. Adv. Res. Biol. Sci

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The study was conducted in twelve clinical cases of cattle undergoing diagnostic and surgical procedures warranting general anaesthesia. The cases were randomly divided into two groups: group I and group II each consisting of six cases. Detomidine @ 30 µg/kg (0.03 mg/kg) body weight and Xylazine @ 0.1 mg/kg body weight were used as pre-anaesthetics in groups I and II respectively. Ketamine @ 2.0 mg/kg body weight and guaifenesin @ 50.0 mg/ml of 5% dextrose solution was used as induction and maintenance agent in both the groups. There was no significant differences observed in the neutrophil, lymphocyte, eosinophil and monocyte counts in both the groups. The magnitude of blood glucose was higher in group II compared to that of group I. A non significant reduction in total serum protein was observed after sedation, after induction, during maintenance and after recovery in both the groups. Group II exhibited a significant increase in plasma cortisol level, whereas in group I, a reduction in plasma cortisol level noticed. Antioxidant activity was more marked in group II when compared to group I.

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“…Other pharmacokinetic factors which may complicate the effects of propofol in the critically ill include: Propofol has detrimental effects on the haemodynamic status 24,25,26,27 as well as the advantage of lung protection in the critically ill, 28 which must be seriously considered when deciding on this anaesthetic technique. This requires starting with low dosages and titrating up to the necessary response.…”

Section: Intravenous Anaesthesiamentioning

confidence: 99%

Anaesthesia for ICU-based procedures: the advantages of and options available for inhalational anaesthesia

Kruger

2010

Southern African Journal of Anaesthesia and Analgesia

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Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock

Cited by 53 publications

References 23 publications

A Comparative Study of Effect of Propofol, Etomidate and Propofol Plus Etomidate Induction on Hemodynamic Response to Endotracheal Intubation: A RCT

A Comparative Study of Effect of Propofol, Etomidate and Propofol Plus Etomidate Induction on Hemodynamic Response to Endotracheal Intubation: A RCT

Oxidative stress response of guaifenesin-ketamine anaesthetized cattle during surgery under detomidine/xylazine premedication

Anaesthesia for ICU-based procedures: the advantages of and options available for inhalational anaesthesia

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