Propofol and gastric effects of morphine

Abstract

Propofol did not abolish morphine-induced delay of gastric emptying even if propofol abolished the decrease of gastric tone induced by morphine.

Gastrointestinal motility and prokinetics in the critically ill

“…Both endogenous and administered opiates, acting via m receptors, may contribute to abnormal upper gastrointestinal motor function [20,21]. Specifically, opiate administration in the critically ill is associated with delayed gastric emptying [3] possibly due to fundal relaxation [22], reduced antral contractions [23] and increased phase 3 frequency [24]. A number of other sedative agents also affect gastrointestinal motility [25][26][27][28][29][30][31][32], however neuromuscular blocking agents appear to have no effect [11].…”

The effect of anesthetic technique on early postoperative gastric emptying: comparison of propofol-remifentanil and opioid-free sevoflurane anesthesia

“…With an inhalation technique without opioids, the effect of inhalation agents on gastric motility may cease quickly after discontinuation of the agent [3]. An intravenous technique with an ultra-shortacting opioid, to minimize the negative opioid effect on motility, combined with propofol, which has antiemetic properties, and to some degree, antagonizes the opioid effect on gastric motility [4], may favor motility. Both methods are, theoretically, optimal for gastric motility.…”

The influence of opioids on gastric function: experimental and clinical studies

“…Previous studies in volunteers have shown that this dose of propofol does not influence gastric tone (155), and it was given at least 30 min before the study started. The intragastric bag was folded carefully around the gastric tube and positioned in the gastric fundus via oral intubation.…”

“…Penagini found that morphine increased gastric tone (172), while Hammas reported a decrease in gastric tone (155). Both studies used the same dose of intravenous morphine (0.1 mg/kg) and both used a gastric barostat.…”