Propionylated high-amylose maize starch alleviates obesity by modulating gut microbiota in high-fat diet-fed mice

Xie, Zhuqing; Yao, Meicun; Castro‐Mejía, Josué L.; Ma, Ming; Zhu, Yuyan; Fu, Xiong; Huang, Qiang; Zhang, Bin

doi:10.1016/j.jff.2023.105447

Cited by 4 publications

(1 citation statement)

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“…In HFD-fed mice, high-amylose corn starch increased and decreased the relative abundances of Firmicutes and Bacteroidetes , respectively, and showed similar regulating properties as inulin, a well-studied prebiotic [ 30 ]. High-amylose maize increased the alpha diversity in HFD-fed mice and restored the populations of Thiotrichaceae, Bifidobacteriaceae, Streptococcaceae, Enterococcaceae, Thermoanaerobacteraceae, Deferribacteraceae, Porphyromonadaceae, Muribaculaceae, Barnesiellaceae, Lactobacillaceae, and Mogibacteriaceae [ 31 ]. In HFD-fed Kunming mice, RS administration restored the relative abundances of Bacteroides , Ruminococcus, and Bifidobacterium [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Heat-Moisture-Treated High-Amylose Rice Flour on Body Weight, Lipid Metabolism, and Gut Microbiome Composition in Obese Rats

Ma,

Takasugi,

Sugawara

et al. 2023

Metabolites

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The rising prevalence of lifestyle diseases, such as type 2 diabetes, cardiovascular diseases, and metabolic syndrome, has increased the need for effective dietary interventions. This study aimed to evaluate the effects of heat-moisture-treated high-amylose rice (HA-HMT) on body weight, lipid metabolism, and gut microbiome composition in a rat model of obesity. Starch digestibility—specifically, resistant starch—has been shown to provide various health benefits, including improved metabolic health and gut microbiome composition. We employed a sequential approach: firstly, utilizing diet-induced obesity rat models fed with HMT-processed and HMT-non-processed low- or high-amylose rice to investigate the potential of amylose content or HMT to alter phenotypic characteristics and lipid metabolism; and secondly, using the optimal rice flour identified in the previous step to explore the underlying mechanisms. Our findings indicate that heat-moisture treatment, rather than the level of the amylose content of the rice, contributes to the observed anti-obesity and cholesterol-lowering effects. We identified candidate genes contributing to the cholesterol-regulating potential and demonstrated that HMT rice flour could influence the gut microbiome, particularly the Ruminococcus taxa. This study provides valuable insights into the health benefits of HA-HMT rice and supports its potential as a functional food ingredient in the management of obesity and cholesterol-related disorders.

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Section: Discussionmentioning

confidence: 99%