Propionibacterium/Cutibacterium species–related positive samples, identification, clinical and resistance features: a 10-year survey in a French hospital

Broly, Martin; d’Epenoux, L. Ruffier; Guillouzouic, A.; Gargasson, G. Le; Juvin, M. E.; Leroy, Anne-Gaëlle; Bémer, Pascale; Corvec, Stéphane

doi:10.1007/s10096-020-03852-5

Cited by 17 publications

(9 citation statements)

References 46 publications

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“…In line with previous studies, we report that C. acnes is the most common species within the genus to be found in isolates from patients with positive blood cultures with Cutibacterium [ 38 ] . In our study, there were too few episodes of positive Cutibacterium blood cultures with species other than C. acnes to draw any conclusions about their clinical features.…”

Section: Discussionsupporting

confidence: 90%

True infection or contamination in patients with positive Cutibacterium blood cultures—a retrospective cohort study

Boman

Nilson

Sunnerhagen

et al. 2022

Eur J Clin Microbiol Infect Dis

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Cutibacterium is a genus often considered a contaminant when present in blood cultures, but it can also cause severe infections, especially related to implanted foreign materials. We investigated the incidence and features of patients with true Cutibacterium infection. Patients with positive Cutibacterium blood cultures between the years 2015–2020 in southern Sweden were identified through microbiology records and medical records were studied retrospectively. Cutibacterium isolates were species determined using MALDI-TOF MS. Patients were classified as having true infection or contamination according to a definition considering both clinical and microbiological features and these groups were compared. A total of 313 episodes of positive Cutibacterium blood cultures were identified in 312 patients. Of these, 49 (16%, corresponding to an incidence of 6 cases per million inhabitants per year) were classified as true infections. The most common species was Cutibacterium acnes (87%), and the majority were elderly men with comorbidities. Patients with true Cutibacterium infection often had an unknown focus of infection (n = 21) or a focus in the respiratory tract (n = 18). We identified one episode of ventriculo-peritoneal shunt infection, three episodes of aortic stent-graft infection, and one episode of infective endocarditis. Two patients, where Cutibacterium was isolated at the site of infection, had only one positive blood culture. The finding of positive Cutibacterium blood cultures should not always be considered contamination. Definitions of true Cutibacterium bacteremia with a demand that more than one blood culture must be positive may miss true infections.

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Section: Discussionsupporting

confidence: 90%

True infection or contamination in patients with positive Cutibacterium blood cultures—a retrospective cohort study

Boman

Nilson

Sunnerhagen

et al. 2022

Eur J Clin Microbiol Infect Dis

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“…30,48,49 All sonication fluid samples tested negative for C. granulosum according to PCR and culture technique. These findings reflect the low abundance in clinical samples 50 and confirm that none of the PJIs was caused by C. granulosum. A prospective diagnostic trial in a larger cohort of patients with a high prevalence of Cutibacterium implanteassociated infections is needed to evaluate the need of including C. granulosum in the multiplex assay.…”

Section: Discussionsupporting

confidence: 66%

Fast and Sensitive Multiplex Real-Time Quantitative PCR to Detect Cutibacterium Periprosthetic Joint Infections

Prinz

Schmid

Zbinden

et al. 2022

The Journal of Molecular Diagnostics

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“…C. granulosum occupies a lower proportion of the normal skin flora and can contribute to skin health ( 20 ). In contrast, C. granulosum , like C. acnes , becomes an opportunistic pathogen and reportedly causes pathogenesis in surgical site infections of artificial joints and endocarditis ( 21 to 25 ). Although Cutibacterium species have recently gained attention as opportunistic pathogens, little is known about antimicrobial resistance in C. granulosum ( 26 , 27 ).…”

Section: Discussionmentioning

confidence: 99%

Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface

et al. 2023

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The emergence of antimicrobial resistance not only in Cutibacterium acnes strain but also other skin bacteria such as Staphylococcus epidermidis is a big concern due to antimicrobial use for the treatment of acne vulgaris. Increased prevalence of macrolides-clindamycin resistant C. acnes relates to the acquisition of exogenous antimicrobial resistance genes. erm (50) is harbored by the multidrug resistance plasmid pTZC1, which has been found in C. acnes and C. granulosum strains isolated from patients with acne vulgaris.

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Propionibacterium/Cutibacterium species–related positive samples, identification, clinical and resistance features: a 10-year survey in a French hospital

Cited by 17 publications

References 46 publications

True infection or contamination in patients with positive Cutibacterium blood cultures—a retrospective cohort study

True infection or contamination in patients with positive Cutibacterium blood cultures—a retrospective cohort study

Fast and Sensitive Multiplex Real-Time Quantitative PCR to Detect Cutibacterium Periprosthetic Joint Infections

Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface

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