Propionibacterium acnes Stimulates Pro-Matrix Metalloproteinase-2 Expression through Tumor Necrosis Factor-α in Human Dermal Fibroblasts

Choi, Jee Young; Piao, Mei Shan; Lee, Jee Bum; Oh, Jong Seok; Kim, In Gyu; Lee, Seung−Chul

doi:10.1038/sj.jid.5701188

Cited by 72 publications

(62 citation statements)

References 43 publications

(46 reference statements)

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“…In an effort to establish a relationship between diagnostic/prognostic optical techniques and laser–tissue interactions, we have employed the rodent dorsal window-chamber model as an in vivo platform19,25,30,76 to evaluate phototherapies designed to eliminate aberrant blood vessels. Based on data collected from over 300 experiments, it was shown that, in the absence of complete acute photocoagulation of the irradiated vessels, the laser-irradiated region of interest (ROI) remains perfused.…”

Section: Combined Laser Treatment and Optical Imagingmentioning

confidence: 99%

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

et al. 2011

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During the last three decades, several laser systems, ancillary technologies, and treatment modalities have been developed for the treatment of port wine stains (PWSs). However, approximately half of the PWS patient population responds suboptimally to laser treatment. Consequently, novel treatment modalities and therapeutic techniques/strategies are required to improve PWS treatment efficacy. This overview therefore focuses on three distinct experimental approaches for the optimization of PWS laser treatment. The approaches are addressed from the perspective of mechanical engineering (the use of local hypobaric pressure to induce vasodilation in the laser-irradiated dermal microcirculation), optical engineering (laser-speckle imaging of post-treatment flow in laser-treated PWS skin), and biochemical engineering (light- and heat-activatable liposomal drug delivery systems to enhance the extent of post-irradiation vascular occlusion).

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Section: Combined Laser Treatment and Optical Imagingmentioning

confidence: 99%

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

et al. 2011

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“…Using gene array expression profiling, Trivedi et al13 reported that most of the genes dysregulated in acne are involved in the inflammation and extracellular matrix remodeling pathways. Choi et al14 have shown that the expression of proMMP-2 is induced by P. acnes through the nuclear factor-kappa B pathway.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study

Emanuele¹,

Bertona²,

Altabas³

et al. 2012

CCID

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PurposeAcne vulgaris is a skin disorder of the sebaceous follicles, involving hyperkeratinization and perifollicular inflammation. Aberrant extracellular matrix remodeling due to matrix metalloproteinases (MMPs) has been associated with the presence of acne conditions. Given the complex pathophysiology of acne, novel topical therapies should include combination products that target multiple pathogenetic mechanisms. In this pilot study we investigated the changes in gene expression of extracellular MMPs, the tissue inhibitors of metalloproteinases, and proinflammatory molecules after 45 days of topical application of a combination product containing nicotinamide, retinol, and 7-dehydrocholesterol in 16 patients with inflammatory acne on their back.Materials and methodsSkin biopsies were obtained before and after treatment for gene expression studies.ResultsQuantitative real-time polymerase chain reaction revealed a significant downregulation of MMP-1, MMP-2, MMP-9, MMP-14, interleukin-6, monocyte chemoattractant protein-1, and macrophage migration inhibitory factor. In contrast, the tissue inhibitors of metalloproteinases and transforming growth factor-β1 were significantly upregulated. The gene expression findings correlated well with the clinical treatment response.ConclusionsThe combination of nicotinamide, retinol, and 7-dehydrocholesterol appears to be effective for acne treatment from both clinical and molecular standpoints.

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“…In one of the previous studies doxycycline was shown to inhibit phosphorylation and nuclear translocation of the NF-kB-p65 and NF-kB-induced MMP-9 expression in lung cancer cell migration and invasion [41]. In another study in human dermal fibroblasts doxycycline inhibited TNF-a--induced NF-kB-mediated MMP-2 expression but not MMP-9 expression [46]. Consistently with the results of these studies, we observed that inhibition of MMP-9 and -8 expression by doxycycline was associated with the down-regulation in the expression of NF-kB/p65, IKK-b and the reduction in the phosphorylation of IkB-a in PC3 prostate cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-κB signaling in LPS-induced PC3 cells

Ogut

Reel

Korkmaz

et al. 2017

Folia Histochem Cytobiol.

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Introduction. Matrix metalloproteinase enzymes (MMPs) play important role in inflammation, malignant cell proliferation, invasion and angiogenesis by mediating extracellular matrix degradation. Doxycycline, a synthetic tetracycline, behaves as a MMP inhibitor at a subantimicrobial dose and inhibits tumor cell proliferation, invasion and angiogenesis. The aberrant activity of nuclear factor kappa B (NF-kB) causes activation of MMPs and thereby proliferation and invasion of cancer cells. The aim of this study was to investigate the effects of doxycycline on the expression of MMPs in lipopolysaccharide (LPS)-induced PC3 human prostate cancer cells and the possible role of NF-kB signaling. Material and methods. PC3 cells were incubated with LPS (0.5 µg/mL) for 24 h in the presence or absence of doxycycline (5 µg/mL). The effects of LPS and doxycycline on the expressions of MMP-2, MMP-8, MMP-9, MMP-10, NF-kB/p65, IkB-a, p-IkB-a, IKK-b were examined by Western blotting and immunohistochemistry in PC3 cells. Furthermore, relative proteinase activities of MMP-2 and MMP-9 were determined by gelatin zymography. Results. LPS increased expression and activity of MMP-9 and expression of MMP-8, MMP-10, NF-kB/p65, p-IkB-a, IKK-b and doxycycline down-regulated its effects with the exception of MMP-10 expression. The expression of MMP-2 and IkB-a was affected by neither LPS nor doxycycline. Conclusions. Our findings indicate that doxycycline inhibits the expression of various MMPs and NF-kB signaling may play a role in the regulation of MMPs expression in LPS-induced PC3 human prostate cancer cells.

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Propionibacterium acnes Stimulates Pro-Matrix Metalloproteinase-2 Expression through Tumor Necrosis Factor-α in Human Dermal Fibroblasts

Cited by 72 publications

References 43 publications

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

An Overview of Three Promising Mechanical, Optical, and Biochemical Engineering Approaches to Improve Selective Photothermolysis of Refractory Port Wine Stains

Anti-inflammatory effects of a topical preparation containing nicotinamide, retinol, and 7-dehydrocholesterol in patients with acne: a gene expression study

Doxycycline down-regulates matrix metalloproteinase expression and inhibits NF-κB signaling in LPS-induced PC3 cells

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