Propionibacterium acnes osteomyelitis: case report and review of the literature

Noble, Robert C.; Overman, Sue B.

doi:10.1128/jcm.25.2.251-254.1987

Cited by 54 publications

(13 citation statements)

References 38 publications

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“…Arthritis may follow steroid injections or involve prosthetic joints (418). Osteomyelitis may follow surgery (314) or endocarditis (419). Surgical wound infections are rare.…”

Section: Genus Propionibacteriummentioning

confidence: 99%

Clinical microbiology of coryneform bacteria

et al. 1997

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Coryneform bacteria are aerobically growing, asporogenous, non-partially-acid-fast, gram-positive rods of irregular morphology. Within the last few years, there has been a massive increase in the number of publications related to all aspects of their clinical microbiology. Clinical microbiologists are often confronted with making identifications within this heterogeneous group as well as with considerations of the clinical significance of such isolates. This review provides comprehensive information on the identification of coryneform bacteria and outlines recent changes in taxonomy. The following genera are covered: Corynebacterium, Turicella, Arthrobacter, Brevibacterium, Dermabacter. Propionibacterium, Rothia, Exiguobacterium, Oerskovia, Cellulomonas, Sanguibacter, Microbacterium, Aureobacterium, "Corynebacterium aquaticum," Arcanobacterium, and Actinomyces. Case reports claiming disease associations of coryneform bacteria are critically reviewed. Minimal microbiological requirements for publications on disease associations of coryneform bacteria are proposed.

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“…Arthritis may follow steroid injections or involve prosthetic joints (418). Osteomyelitis may follow surgery (314) or endocarditis (419). Surgical wound infections are rare.…”

Section: Genus Propionibacteriummentioning

confidence: 99%

Clinical microbiology of coryneform bacteria

et al. 1997

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“…It has been isolated in cases of spinal osteomyelitis and discitis. 5,9,16 Stirling and colleagues suggested a possible link between P. acnes and sciatica. 22 Despite the apparent association between P. acnes and the spine no study to date quantifies the incidence of intraoperative wound contamination during spinal surgery.…”

mentioning

confidence: 99%

Propionibacterium acnes Wound Contamination at the Time of Spinal Surgery

McLorinan

Glenn²,

Mcmullan³

et al. 2005

Clinical Orthopaedics and Related Research

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Bacteria of the normal skin microbiota such as Propionibacterium acnes and coagulase-negative staphylococci often are dismissed as contaminants when detected in clinical samples. Propionibacterium acnes is described as a cause of spinal infection and more recently has been linked to sciatica. To date no researchers formally have examined the incidence of bacterial wound contamination during spinal surgery. Surgical specimens were removed from 79 patients having spinal surgery for analysis using agar culture detection, broth enrichment, and immunofluorescence microscopy. Bacteria were identified in 29.1% of skin samples, 21.5% of tissue samples and 16.5% of washings retrieved from operative wounds. Propionibacterium acnes was identified more frequently than Staphylococcus spp in each of the three sample types. Bacteria were detected using enrichment in 9 (11%) patients and using fluorescence microscopy in 15 (19%). The results of immunofluorescence microscopy suggest that Propionibacterium acnes detected in wounds originates from patient skin. Bacteria from contaminated wounds appeared as single cells using fluorescence microscopy; however previous work shows that bacteria from infected hip prosthesis are observed as large aggregates. Therefore, it is suggested that immunofluorescence microscopy is a useful tool to help discriminate between surgical contamination and infection. Level of Evidence: Diagnostic study, Level I (prospective study). See the Guidelines for Authors for a complete description of levels of evidence.

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“…26 The rare reported cases of hematogenous osteomyelitis assigned to corynebacteria occurred in immunocompromised hosts. 27 In summary, we present a 67-yr-old male patient with a chondroblastic osteosarcoma of the thoracic vertebral column. This neoplasm may have arisen secondary to Paget's disease; the sclerotic changes noted in the native bone were suggestive yet not diagnostic of this condition.…”

Section: Fnab Of Osteosarcoma Of Vertebral Columnmentioning

confidence: 95%

“…25,26 Corynebacteria represent a rare cause of osteomyelitis, which is usually attributable to direct inoculation during surgical or other invasive procedures. [25][26][27][28][29][30][31] They frequently form part of a mixed culture and are thus overlooked as potential pathogens in deference to the identification of more virulent skin commensals. 26 The rare reported cases of hematogenous osteomyelitis assigned to corynebacteria occurred in immunocompromised hosts.…”

Section: Fnab Of Osteosarcoma Of Vertebral Columnmentioning

confidence: 99%

Fine‐needle aspiration biopsy of chondroblastic osteosarcoma of the vertebral column complicated by Corynebacterium infection: A case report

Chateau¹,

Commons²,

O'Neil³

1999

Diagn. Cytopathol.

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We describe a case of chondroblastic osteosarcoma of the vertebral column in a 67-yr-old male in whom the preoperative diagnosis was made by fine-needle aspiration biopsy (FNAB).Key Words: osteosarcoma; vertebral column; fine-needle aspiration biopsy; complications; cytology Although osteosarcoma represents the most common primary sarcoma of bone, it occurs only rarely in the vertebral column. 1,2 This location accounts for 1-3% of biopsyproven osteosarcomas and half of these cases develop secondary to radiation therapy, Paget's disease, or malignant transformation of a benign neoplasm such as osteoblastoma. [3][4][5] The diagnosis and treatment of vertebral osteosarcoma often present a serious challenge, and the management of this neoplasm has evolved considerably over the past few decades. 6 This case report describes a patient with primary osteosarcoma of the eighth thoracic vertebra diagnosed preoperatively by fine-needle aspiration biopsy (FNAB). This procedure was complicated by Corynebacterium infection. We review the literature on the subject of osteosarcoma of the vertebral column, present the features that distinguish this lesion from osteoblastoma, and discuss the diagnosis of bone tumors by FNAB, a diagnostic modality that figures prominently in the evaluation of lesions of the vertebral column. Case ReportThis 67-yr-old male with coronary artery disease presented with unremitting interscapular pain. Although he denied any recent injury, he had fallen from his roof approximately 18 mo prior to the onset of his back pain. In retrospect, it does not appear that he sustained a significant injury in this fall since a routine chest X-ray performed 6 mo later failed to reveal any pathology in the thoracic vertebral column. Over the course of 1 mo, his back pain increased in intensity, leading to radiological investigation. A plain X-ray of the thoracolumbar vertebral column revealed a fracture of the T8 end plate with sparing of the pedicles. A technetium pyrophosphate bone scan showed intense uptake of the radioisotope in the T8 vertebral body with no other focal lesions. A chest X-ray and abdominal ultrasound failed to reveal any suspicious lesions and laboratory investigations, which included a serum prostate specific antigen (PSA) and serum protein electrophoresis, were within normal limits. The patient was managed with nonsteroidal anti-inflammatory agents and narcotic analgesics which temporarily alleviated his back pain. Upon returning from a summer

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Propionibacterium acnes osteomyelitis: case report and review of the literature

Cited by 54 publications

References 38 publications

Clinical microbiology of coryneform bacteria

Clinical microbiology of coryneform bacteria

Propionibacterium acnes Wound Contamination at the Time of Spinal Surgery

Fine‐needle aspiration biopsy of chondroblastic osteosarcoma of the vertebral column complicated by Corynebacterium infection: A case report

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