Propionibacterium acnes infection associated with cancerous prostate hypertrophy

Olender, Alina; Radej, Sebastian; Płaza, Paweł; Bar, Krzysztof; Maciejewski, Ryszard

doi:10.20452/pamw.3553

Cited by 4 publications

(3 citation statements)

References 6 publications

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“…Based on our previous research that P. acnes occurs with the highest frequency in EOC patients, we speculate that P. acnes is a key strain in facilitating EOC progression. P. acnes is a typical opportunistic bacterium commonly occurring on the skin, especially associated with acne vulgaris [ 36 ]. It is confirmed that P. acnes can induce intervertebral disc degeneration by promoting iNOS/NO and COX-2/PGE2 activation via the ROS-dependent NF-κB pathway, and recent studies have also highlighted its role in oncogenesis [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Endogenous Propionibacterium acnes Promotes Ovarian Cancer Progression via Regulating Hedgehog Signalling Pathway

Huang

Wei

et al. 2022

Cancers

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Background: The oncogenesis and progression of epithelial ovarian cancer (EOC) is a complicated process involving several key molecules and factors, yet whether microbiota are present in EOC, and their role in the development of EOC, remains greatly unknown. Methods: In this study, 30 patients were enrolled to compare the similarities and differences of intratumour microbiota among patients with epithelial benign ovarian tumours (EBOTs) and patients with EOC based on the high-throughput sequencing method. Subsequently, we further isolated the specific EOC-related bacteria and defined Propionibacterium acnes as a key strain in facilitating EOC progression. More importantly, we constructed a mouse EOC model to evaluate the effect of the P. acnes strain on EOC using immunohistochemistry, Western blotting, and RT-qPCR. Results: The high-throughput sequencing showed that the intratumour microbiota in EOC tissues had a higher microbial diversity and richness compared to EBOT tissues. The abundance of previously considered pathogens, Actinomycetales, Acinetobacter, Streptococcus, Ochrobacterium, and Pseudomonadaceae Pseudomonas, was increased in the EOC tissues. Meanwhile, we discovered the facilitating role of the P. acnes strain in the progression of EOC, which may be partially associated with the increased inflammatory response to activate the hedgehog (Hh) signalling pathway. This microbial-induced EOC progression mechanism is further confirmed using the inhibitor GANT61. Conclusions: This study profiled the intratumour microbiota of EBOT and EOC tissues and demonstrated that the diversity and composition of the intratumour microbiota were significantly different. Furthermore, through in vivo and in vitro experiments, we confirmed the molecular mechanism of intratumour microbiota promotion of EOC progression in mice, which induces inflammation to activate the Hh signalling pathway. This could provide us clues for improving EOC treatment.

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Section: Discussionmentioning

confidence: 99%

Endogenous Propionibacterium acnes Promotes Ovarian Cancer Progression via Regulating Hedgehog Signalling Pathway

Huang

Wei

et al. 2022

Cancers

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“…Therefore, P . acnes infection may be a contributing factor to the development of prostate cancer [ 26 , 27 ]. In theory, incorporating some simple factors, such as age, family history, and new reported markers (e.g., HPV-16 infection [ 28 ] and hypertension [ 29 ]), into prostate cancer risk calculators may help identify men with a relatively high risk of prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Is acne in adolescence associated with prostate cancer risk? Evidence from a meta-analysis

et al. 2018

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IntroductionPrevious studies regarding the relationship between acne and prostate cancer risk have reported inconsistent results. We performed the present meta-analysis of observational studies to summarize the evidence on this association.MethodsA comprehensive literature search up to March 2018 was performed in PubMed, Scopus, Web of Science, and Chinese National Knowledge Infrastructure (CNKI) databases. Summary odds ratios (ORs) with 95% confidence intervals (CIs) were estimated with a random effects model. The Q statistic and the I2 index were used to evaluate the heterogeneity across the studies.ResultsEight studies were ultimately included in this meta-analysis. In the overall analysis, no significant association was found between acne and prostate cancer risk (OR = 1.08, 95% CI 0.93–1.25). A significant heterogeneity was observed across studies (P = 0.006, I2 = 64.5%). In the subgroup analysis by study design, a significant association was observed in the cohort studies (OR = 1.51, 95% CI 1.19–1.93) but not in the case-control studies (OR = 0.98, 95% CI 0.86–1.12).ConclusionsIn summary, this meta-analysis did not find an association between acne in adolescence and prostate cancer risk. However, because there was some heterogeneity in the overall analysis and a significant association was observed in the meta-analysis of the cohort studies, further well-designed large prospective studies are warranted to confirm our results.

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“…Propionibacterium acnes ( P. acnes ) is an anaerobic, Gram‐positive, and opportunistic microorganism, but is also responsible for chronic infections, such as prostatitis. Studies report P. acnes in prostate tissue from patients with benign prostate hyperplasia and prostate cancer (Olender, Radej, Płaza, Bar, & Maciejewski, 2016; Olsson et al, 2012; Sutcliffe & Platz, 2008). The high prevalence of P. acnes in the prostate tissue and its strong inflammatory‐promoting properties suggest the possibility that P. acnes plays a role in the pathogenesis of common prostate disorders, such as prostatitis and prostate tumors (Nickel & Xiang, 2008; Olender et al, 2016; Olsson et al, 2012; Sutcliffe & Platz, 2008).…”

Section: Introductionmentioning

confidence: 99%

Application of an LC–ESI–QTOF–MS method for evaluating clindamycin concentrations in plasma and prostate microdialysate of rats

Ritter

Possa

Bergoza

et al. 2020

Biomedical Chromatography

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Clindamycin is used for infections caused by Gram-positive and Gram-negative anaerobic pathogens and Gram-positive aerobes. Propionibacterium acnes is an important opportunistic microorganism of the human skin and is related to prostatitis. An LC-electrospray ionization-quadrupole time-of-flight-MS method was validated for determining clindamycin concentrations in plasma and prostate microdialysate. Clindamycin separation was carried out on a C 18 column at 0.5 mL/min. The mobile phase employed gradient elution of formic acid and methanol. A mass spectrometer was operated in positive electrospray ionization mode to monitor ion 425.1784 and 253.1152 for clindamycin and cimetidine (internal standard), respectively. Linearity was obtained at 0.5-10.0 μg/mL (plasma) and 0.05-1.0 μg/mL (microdialysate) with coefficients of determination ≥0.999. The intra-and inter-day precision (coefficient of variation-CV%) values were ≤13.83% and 12.51% for plasma, respectively, and ≤10.90% and 9.35% for microdialysate, respectively. The accuracy was between 90.82% and 108.25% for plasma, and 96.97% and 106.98% for microdialysate. The present method was fully validated and applied to investigate clindamycin concentrations in both plasma and prostate by microdialysis in Wistar rats (80 mg/kg, intravenous). Because the penetration of antibiotics into the prostate may be restricted, this method allows us to investigate the prostate concentrations of clindamycin for the first time. K E Y W O R D S clindamycin, LC-ESI-QTOF-MS, microdialysis, prostate 1 | INTRODUCTION Clindamycin, a lincosamide antibiotic, is used for bacterial infections caused by Gram-positive and Gram-negative anaerobic pathogens, and Gram-positive aerobes (Bratzler et al., 2013). Among other indications, clindamycin is used to treat vulgaris acne, prostheses prophylaxis, osteomyelitis, and joint infections (Ino

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Propionibacterium acnes infection associated with cancerous prostate hypertrophy

Cited by 4 publications

References 6 publications

Endogenous Propionibacterium acnes Promotes Ovarian Cancer Progression via Regulating Hedgehog Signalling Pathway

Endogenous Propionibacterium acnes Promotes Ovarian Cancer Progression via Regulating Hedgehog Signalling Pathway

Is acne in adolescence associated with prostate cancer risk? Evidence from a meta-analysis

Application of an LC–ESI–QTOF–MS method for evaluating clindamycin concentrations in plasma and prostate microdialysate of rats

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