Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related hypersensitivity pneumonitis

Sawahata, Michiru; Sakamoto, Noritaka; Yamasawa, Hideaki; Iijima, Yuki; Kawata, Hirotoshi; Yamaguchi, Tetsuo; Uchida, Keiji; Eishi, Yoshinobu; Bando, Masashi; Hagiwara, Koichi

doi:10.1186/s12890-020-01327-z

Cited by 2 publications

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References 22 publications

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“…Localization of the immunohistochemical signals to C. acnes in sarcoid granulomas is shown in Figure 1 . Numerous case reports have described C. acnes detection in the granulomas of patients with pulmonary sarcoidosis [ 22 , 23 , 24 , 25 ], cutaneous sarcoidosis [ 26 , 27 , 28 , 29 , 30 , 31 ], nasal sarcoidosis [ 32 ], and neurosarcoidosis [ 33 , 34 ]. The term “ C. acnes -associated sarcoidosis” is applied to cases in which C. acnes is detected in granulomas via immunohistochemistry using the PAB antibody [ 35 ].…”

Section: C Acnes In Sarcoid Granulomasmentioning

confidence: 99%

Potential Association of Cutibacterium acnes with Sarcoidosis as an Endogenous Hypersensitivity Infection

Eishi

2023

Microorganisms

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The immunohistochemical detection of Cutibacterium acnes in sarcoid granulomas suggests its potential role in granuloma formation. C. acnes is the sole microorganism ever isolated from sarcoid lesions. Histopathologic analysis of some sarcoid lymph nodes reveals latent infection and intracellular proliferation of cell-wall-deficient C. acnes followed by insoluble immune-complex formation. Activation of T helper type 1 (Th1) immune responses by C. acnes is generally higher in sarcoidosis patients than in healthy individuals. Pulmonary granulomatosis caused by an experimental adjuvant-induced allergic immune response to C. acnes is preventable by antimicrobials, suggesting that the allergic reaction targets C. acnes commensal in the lungs. C. acnes is the most common bacterium detected intracellularly in human peripheral lungs and mediastinal lymph nodes. Some sarcoidosis patients have increased amounts of C. acnes-derived circulating immune complexes, which suggests the proliferation of C. acnes in affected organs. In predisposed individuals with hypersensitive Th1 immune responses to C. acnes, granulomas may form to confine the intracellular proliferation of latent C. acnes triggered by certain host-related or drug-induced conditions. Current clinical trials in patients with cardiac sarcoidosis are evaluating combined treatment with steroids and antimicrobials during active disease with continued antimicrobial therapy while tapering off steroids after the disease subsides.

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Section: C Acnes In Sarcoid Granulomasmentioning

confidence: 99%

Potential Association of Cutibacterium acnes with Sarcoidosis as an Endogenous Hypersensitivity Infection

Eishi

2023

Microorganisms

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“…Many case reports with P. acnes detected in granulomas, including pulmonary sarcoidosis [ 54 , 55 ], cutaneous sarcoidosis [ 56 , 57 , 58 , 59 , 60 , 61 , 62 ], nasal sarcoidosis [ 63 ], and neurosarcoidosis [ 64 , 65 ], have been published. These cases in which P. acnes was identified in granulomas by IHC with the PAB antibody were recently termed P. acnes -associated sarcoidosis [ 55 , 64 , 65 , 66 , 67 , 68 ].…”

Section: M Tuberculosis and P Acnesmentioning

confidence: 99%

Immunohistochemical Detection of Potential Microbial Antigens in Granulomas in the Diagnosis of Sarcoidosis

Yamaguchi

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McDowell

et al. 2021

JCM

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Sarcoidosis may have more than a single causative agent, including infectious and non-infectious agents. Among the potential infectious causes of sarcoidosis, Mycobacterium tuberculosis and Propionibacterium acnes are the most likely microorganisms. Potential latent infection by both microorganisms complicates the findings of molecular and immunologic studies. Immune responses to potential infectious agents of sarcoidosis should be considered together with the microorganisms detected in sarcoid granulomas, because immunologic reactivities to infectious agents reflect current and past infection, including latent infection unrelated to the cause of the granuloma formation. Histopathologic data more readily support P. acnes as a cause of sarcoidosis compared with M. tuberculosis, suggesting that normally symbiotic P. acnes leads to granuloma formation in some predisposed individuals with Th1 hypersensitivity against intracellular proliferation of latent P. acnes, which may be triggered by certain host or drug-induced conditions. Detection of bacterial nucleic acids in granulomas does not necessarily indicate co-localization of the bacterial proteins in the granulomas. In the histopathologic diagnosis of sarcoidosis, M. tuberculosis-associated and P. acnes-associated sarcoidosis will possibly be differentiated in some patients by immunohistochemistry with appropriate antibodies that specifically react with mycobacterial and propionibacterial antigens, respectively, for each etiology-based diagnosis and potential antimicrobial intervention against sarcoidosis.

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Propionibacterium acnes-associated sarcoidosis complicated by acute bird-related hypersensitivity pneumonitis

Cited by 2 publications

References 22 publications

Potential Association of Cutibacterium acnes with Sarcoidosis as an Endogenous Hypersensitivity Infection

Potential Association of Cutibacterium acnes with Sarcoidosis as an Endogenous Hypersensitivity Infection

Immunohistochemical Detection of Potential Microbial Antigens in Granulomas in the Diagnosis of Sarcoidosis

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