Prophylaxis of Upper Airway Infections in a Patient with Partial IgA Deficiency: Concurrent Use of Sublingual Immunotherapy with Inactivated Whole-Cell Bacterial Extract and Der p1

Abstract

Selective IgA deficiency is the most common type of primary immunodeficiency, but there is not yet a specific effective treatment. The most prevalent clinical manifestations are infectious diseases of the respiratory system. We report herein the case of an 11-year-old female with selective IgA deficiency and recurring episodes of respiratory infections associated with rhinitis and asthma. We evaluated the efficacy of sublingual immunotherapy combined with inactivated whole-cell bacterial extract and Der p1-specific immunotherapy. After 18 months of clinical follow-up, we observed a significant reduction in the number of episodes of respiratory infections associated with control of atopic diseases. We also observed a 3-fold increase in serum IgA levels compared to treatment initiation. This case demonstrates the potential utility of the concurrent use of sublingual immunotherapy with inactivated whole-cell bacterial extract and Der p1 for successful control of allergy and infection in partial selective IgA deficiency.

Eurofins Covid-19 Sentinel™ Wastewater Test Provide Early Warning of a potential COVID-19 outbreak

“…Neither the Eurofins primers nor the RNA extractors were previously validated for use with sludge. There is, however, no consensus in the literature for limiting testing to the liquid phase, (Wu, et al, 2020), the sludge phase (Peccia, et al, 2020) or both phases (Aarestrup, 2020). As a consequence of the lack of consensus, the testing protocol was enhanced to consider both the solid and liquid phases with consideration that one potentially could be ignored in future studies.…”