Prophylaxis of Mucosal Toxicity by Oral Propantheline and Cryotherapy in Children with Malignancies Undergoing Myeloablative Chemo-Radiotherapy

Satō, Atsushi; Saisho-Hattori, Takako; Koizumi, Yoshitsugu; Minegishi, Masayoshi; Iinuma, Kazuie; Imaizumi, Masue

doi:10.1620/tjem.210.315

Cited by 21 publications

(25 citation statements)

References 15 publications

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“…This suggestion is based on two case series [16,20], four non-randomized clinical trials [14,15,19,21], and three RCTs [17, 18; 22 supplemented by 23] (Table 2). The collective evidence was scored as level III.…”

Section: Resultsmentioning

confidence: 99%

“…Despite this limitation, consistency of the results over several selected studies and the benefits seen for days after treatment supported the continuation of the guidelines published in 2007. In addition, only two studies [17,21] investigated oral cryotherapy in pediatric populations. There is thus limited study of this intervention in this cancer cohort.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Peterson

Öhrn

Bowen

et al. 2012

Support Care Cancer

115

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Purpose This systematic review analyzed the strength of the literature and defined clinical practice guidelines for the use of oral cryotherapy for the prevention and/or treatment of oral mucositis caused by cancer therapy. Methods A systematic review on relevant oral cryotherapy studies indexed prior to 31 December 2010 was conducted by the Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral Oncology (MASCC/ISOO) using OVID/MEDLINE, with publications selected for review based on defined inclusion and exclusion criteria. Findings from the reviewed studies were integrated into guidelines based on the overall level of evidence for each intervention. Guidelines were classified into three types: recommendation, suggestion, or no guideline possible. of oral cryotherapy to prevent oral mucositis in patients receiving high-dose melphalan as conditioning regimen with or without total body irradiation for HCST was revised from the 2007 guidelines. No guideline was possible for any other intervention, due to insufficient evidence. Conclusions The evidence continues to support the use of oral cryotherapy for prevention of oral mucositis in patients receiving bolus 5-FU chemotherapy or high-dose melphalan. This intervention is consistent with the MASCC/ISOO guidelines published in 2007. The literature is limited by the fact that utilization of a double-blind study design is not feasible. Future studies that compare efficacy of oral cryotherapy with other mucositis agents in patients receiving chemotherapy with relatively short plasma half-lives would be useful.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Peterson

Öhrn

Bowen

et al. 2012

Support Care Cancer

115

View full text Add to dashboard Cite

show abstract

“…One clinical trial showed that propantheline and oral cryotherapy may be feasible and effective in reducing mucosal toxicity in cancer patients receiving high-dose CT (200). However, studies are needed for RIOM.…”

Section: Symptomatic Treatment Of Riommentioning

confidence: 99%

Radiation-Induced Oral Mucositis

2017

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Radiation-induced oral mucositis (RIOM) is a major dose-limiting toxicity in head and neck cancer patients. It is a normal tissue injury caused by radiation/radiotherapy (RT), which has marked adverse effects on patient quality of life and cancer therapy continuity. It is a challenge for radiation oncologists since it leads to cancer therapy interruption, poor local tumor control, and changes in dose fractionation. RIOM occurs in 100% of altered fractionation radiotherapy head and neck cancer patients. In the United Sates, its economic cost was estimated to reach 17,000.00 USD per patient with head and neck cancers. This review will discuss RIOM definition, epidemiology, impact and side effects, pathogenesis, scoring scales, diagnosis, differential diagnosis, prevention, and treatment.

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“…Patients developing severe OM during chemotherapy generally require supportive care measures, such as early and aggressive treatments against neutropenic infection, pain management, and the use of TPN, resulting in significant increases in medical expenses and deteriorations in quality of life 21 . Sato et al reported the efficacy of cryotherapy in combination with oral propantheline for mucositis in children with malignancies receiving various myeloablative regimens 22 . The present study evaluated the utility of cryotherapy in relatively large cohort of pediatric patients receiving uniformly the MEL‐ETP‐CBDCA regimen, which clearly demonstrates its clinically significant efficacy for preventing high‐dose MEL‐induced OM.…”

Section: Discussionmentioning

confidence: 99%

Effects of cryotherapy on high‐dose melphalan‐induced oral mucositis in pediatric patients undergoing autologous stem cell transplantation

Kawaguchi

Umeda

Takachi

et al. 2020

Pediatric Blood & Cancer

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Cryotherapy is a conventional method for preventing melphalan‐induced oral mucositis (OM) in adult patients. We retrospectively examined the clinical benefits of cryotherapy in 41 pediatric patients undergoing autologous stem cell transplantation using a melphalan‐etoposide‐carboplatin regimen. Twenty‐two patients received cryotherapy. The cumulative incidence of grade 3‐4 OM was significantly lower in the cryotherapy group (57.1%) than in the noncryotherapy group (89.5%; P = .041). Multivariate analyses identified cryotherapy and the melphalan dose as independent factors for the lower occurrence of OM. The present study demonstrates the clinically significant efficacy of cryotherapy for preventing melphalan‐induced OM in pediatric patients.

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Prophylaxis of Mucosal Toxicity by Oral Propantheline and Cryotherapy in Children with Malignancies Undergoing Myeloablative Chemo-Radiotherapy

Cited by 21 publications

References 15 publications

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Systematic review of oral cryotherapy for management of oral mucositis caused by cancer therapy

Radiation-Induced Oral Mucositis

Effects of cryotherapy on high‐dose melphalan‐induced oral mucositis in pediatric patients undergoing autologous stem cell transplantation

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