Prophylaxis of Cervical Cancer and Related Cervical Disease: A Review of the Cost-Effectiveness of Vaccination Against Oncogenic HPV Types

Abstract

BACKGROUND: Vaccines have demonstrated cost-effectiveness in managed care through the prevention of disease. As new vaccines for previously untargeted conditions are developed, pharmacoeconomic modeling is becoming even more critical for the quantification of value in the health care industry. Two recently developed vaccines aimed at prevention of infection from human papillomavirus (HPV) types 16 and 18 have proven to be highly efficacious. HPV 16 and 18 are the 2 most common oncogenic strains of HPV and are responsible for 70% of cervical cancer cases worldwide. Persistent infection with an oncogenic HPV type is a known cause of cervical cancer. Therefore, prevention of cervical cancer via HPV vaccination may have a significant financial impact.

Histone Deacetylase (HDAC) 10 Suppresses Cervical Cancer Metastasis through Inhibition of Matrix Metalloproteinase (MMP) 2 and 9 Expression

“…Cervical cancer is the second most common and the fifth deadliest cancer in women in the world (45). Prognosis drops dramatically in patients with invasive cervical cancer.…”

Factors Associated with Decisions to Attend Cervical Cancer Screening among Women Aged 30-60 Years in Chatapadung Contracting Medical Unit, Thailand

“…Cervical cancer is the second most prevalent cancer among women worldwide, with 500,000 new cases and 250,000 deaths reported each year (Armstrong, 2010). It occurs most often in women over age 30.…”

Prevalence of abnormal Papanicolaou smears in female sex workers in Hong Kong

“…1 Since its introduction in 1941, Papanicolaou (Pap) smear screening is believed to have reduced the number of cervical cancer-related deaths by approximately 74% or by approximately 2% per year. 2 This improvement was seen in nearly every country promoting women's awareness and participation in cervical health screening programmes, making it the most successful health screening programme of the century against cancer.…”