Prophylaxis of Aphakic Cystoid Macular Edema without Corticosteroids

Reducing angiographic cystoid macular edema and blood–aqueous barrier disruption after small-incision phacoemulsification and foldable intraocular lens implantation

“…Although the efficacy of NSAIDs in minimizing complications after ocular surgery has been described, [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22]26,28,29 their effectiveness has not been adequately compared with that of betamethasone. 23 Topical indomethacin was the first NSAID confirmed to block miosis during aspiration of soft cataracts 29 and to prevent CME after intracapsular cataract extraction.…”

“…6 Thus, we specifically discussed acute or angiographic CME in this study, which is why the incidence of CME was higher than that in previous studies. [19][20][21]23,35 Acute or angiographic CME resolves spontaneously approximately 13 weeks after surgery. 36 In conclusion, diclofenac was more effective than betamethasone in preventing CME and BAB disruption in pseudophakic eyes that had modern smallincision cataract and IOL surgery.…”

“…[6][7][8] One approach to preventing the negative effects of these mediators is to treat eyes with CME using nonsteroidal antiinflammatory drugs (NSAIDs) that inhibit PG synthesis. [9][10][11][12][13][14][15][16][17][18][19][20][21][22] Although systematic reviews acknowledge there is convincing clinical evidence that NSAIDs are effective in preventing and treating CME, they also indicate that further studies are warranted as previous studies had shortcomings involving the design and the length of the observation period. 23,24 The rate of CME differs depending on the surgical technique used.…”

Incidence of visually significant pseudophakic macular edema after uneventful phacoemulsification in patients treated with nepafenac

“…Although the U.S. Food and Drug Administration has not approved any NSAID for the prevention or treatment of CME, several studies have evaluated the efficacy of these agents for this indication. 3,[8][9][10][11][12][13][14][15][16][17] The purpose of this study was to evaluate the efficacy of nepafenac, a prodrug arylacetic acid NSAID introduced in 2005, in preventing visually significant pseudophakic macular edema after cataract surgery and review the results in relation to the current literature on NSAIDs for the prevention of CME after uneventful cataract surgery.…”

Effect of prophylactic nonsteroidal antiinflammatory drugs on cystoid macular edema assessed using optical coherence tomography quantification of total macular volume after cataract surgery

“…One randomized control trial found ketorolac tromethamine 0.5% was effective in treating angiographic CME after cataract surgery. 8 Several other studies 9-15 support the use of antiinflammatory compounds in cataract surgery.…”