Prophylaxie anti-infectieuse après agression sexuelle: expérience de l'hôpital Raymond-Poincaré

Adherence to HIV post-exposure prophylaxis in victims of sexual assault: a systematic review and meta-analysis

“…These included two conference abstracts 20 21. and one non-English publication (French) 22. Unpublished reports and non-peer-reviewed reports were not included.…”

“…Most studies did not report data on the number of patients that refused PEP. Seven studies reported on refusals3 7 8 15 22 28 32 and of these, two studies had refusal rates of greater than 20% 7 15. The reasons for discontinuing PEP were poorly documented overall, and side effects were not reported in seven studies 3 7 25 27 33 35 36.…”

“…Eight studies used two-drug regimens,4 7 24 25 34 36 37 39 seven studies used three-drug regimens,15 21 22 28–30 38 while five studies prescribed both two- and three-drug regimens 3 9 27 31 32. One study provided different regimens according to the severity of the sexual assault 32.…”

“…PEP dispensing practices varied between studies. Eight studies provided patients with starter packs 3 7 8 20 22 24 26 34. The duration of the starter packs ranged from 2 to 7 days.…”

“…The duration of the starter packs ranged from 2 to 7 days. Two studies provided all the medication at once28 29 and four studies dispensed 7-day packs 22 25 27 36. One study found that patients given a full course of drugs on the first visit were more likely to be fully adherent compared with those given a starter pack with follow-up appointments (at which the remaining PEP was provided) (71% vs 29%) 33…”