Prophylaktische Anwendung von Tranexamsäure in der nichtkardialen Chirurgie

Waskowski, Jan; Schefold, Joerg C.; Stueber, Frank

doi:10.1007/s00063-018-0402-5

Cited by 2 publications

(2 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These findings were comparable with our results. Strengthening the findings of present study WaskowskiJ et al, (2018) [16] in their review reported that TXA reduces perioperative blood loss and transfusion requirements in several randomized controlled trials. TA is beneficial in complex spine surgery and reconstructive surgery (e. g. craniosynostosis in children).…”

Section: Discussionsupporting

confidence: 74%

“…Single RCTs showed benefits of TXA in abdominal hysterectomy, open prostatectomy, liver surgery and actively bleeding trauma patients. (Waskowski J 2018) [16] WOMEN trial recruited 20 060 women aged 16 years and older with a clinical diagnosis of postpartum haemorrhage and reported that death due to bleeding was significantly reduced in women given tranexamic acid (155 [1•5%] of 10 036 patients vs 191 [1•9%] of 9985 in the placebo group and concluded that TA reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects (WOMAN Trial Collaborators 2017) [17] . Use of topical hemostatics was higher among the control (77%) as compared to Cases (37%) (p=0.012) Contrary to present study reports of Topsoee MF et al, (2016) [11] showed that use of intraoperative topical hemostatics was not significantly different in both the groups which is in agreement to the finds of the ~ 97 ~ present study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of prophylactic use of intravenous tranexamic acid in hysterectomy of benign diseases

Singh¹,

Bindal²

2020

Int. J. Clin. Obstet. Gynaecol.

View full text Add to dashboard Cite

Background: Hysterectomy is one of the frequently performed major gynecological surgical procedures for various uterine pathologies. TXA has already proven to reduce the uterine blood loss in non-surgical aspect. Various studies had revealed that TXA resulted in a significant reduction of menstrual blood loss in menorrhagic women while not increasing the risk of thrombosis and had been used successfully to treat menorrhagia associated with a number of coagulopathies. Material and Methods: This prospective study conducted on 200 women in Department of Obstetrics &for one year period. They were divided in two groups: Cases: (n=100; women receiving prophylactic Tranexamic Acid) and Control: (n=100; women receiving saline). Estimated the amount of blood loss during surgery. The amount of blood loss during surgery were calculated Estimation of weight of dry towels and mops before autoclaving is noted. Results: Most common age group among Cases and Control was 36-45 years [45% vs. 52%]. Age among. Mean age among cases group (46.69±7.51 years) was significantly higher compared to control study cohort (41.75±7.72). Comparing the duration of operation among both the study groups revealed that time taken for hysterectomy took longer time among Cases (9136.69±26.49) as compared to Control (131.61±26.75) (p=0.004). Post operative hemoglobin level was significantly higher among Case (11.26±12.03) as compared to Control (8.56±1.01). Comparing post operative complications revealed that among both the groups post operative complications were comparable. Use of topical hemostatics was higher among the control (77%) as compared to Cases (37%). Conclusion: Prophylactic treatment with TA in relation to benign elective hysterectomy reduces the overall total blood loss, and the risk of reoperations owing to postoperative hemorrhage as revealed by higher hemoglobin level among cases.

show abstract

Section: Discussionsupporting

confidence: 74%

Section: Discussionmentioning

confidence: 99%

The effect of prophylactic use of intravenous tranexamic acid in hysterectomy of benign diseases

Singh¹,

Bindal²

2020

Int. J. Clin. Obstet. Gynaecol.

View full text Add to dashboard Cite

show abstract

To Evaluate the Effect of Prophylactic Use of Trenexamic Acid on Bleeding During Elective Lscs. A Study Conducted in Tertiary Care Hospital of Central India.

Singh

Bhargava

2021

Global Journal for Research Analysis

View full text Add to dashboard Cite

Background: Recent guidelines of the World Health Organization (WHO) indicated administering tranexamic acid (TXA) in order to treat postpartum bleeding (PPH). Therefore, nding low-cost and lowrisk alternative methods to control obstetric bleeding is of great importance. The present study aimed to evaluate the prophylactic effect of TXA on bleeding during and after the LSCS. In addition, it was attempted to explore the impact of TXA as a safe and inexpensive method for decreasing bleeding during and after CS so that to decrease the hazard of blood transfusion or hysterectomy in these patients. Material and Methods: This prospective study conducted on 100 women in Department of Obstetrics &gynecolgy for one year period. They were divided in two groups: Cases: (n=50; women receiving prophylactic Tranexamic Acid) and Control: (n=50; women receiving saline). Estimated the amount of blood loss during surgery. The amount of blood loss during surgery were calculated Estimation of weight of dry towels and mops before autoclaving is noted. Results: Most common age group among Cases and Control was 26-30 years .%. Mean age among cases group (26.69±7.51 years) was signicantly lesser compared to control study cohort (29.75±7.72). Post operativehemoglobin level was signicantly higher among Case (11.26±12.03) as compared to Control (8.56±1.01). Comparing post operative complications revealedno signicant changes. Use of topical hemostatics was higher among the control (77%) as compared to Cases (57%). Conclusion: Prophylactic treatment with TXA in relation to elective LSCS reduces the overall total blood loss, and the risk of reoperations owing to postoperative hemorrhage as revealed by higher hemoglobin level among cases.

show abstract

Prophylaktische Anwendung von Tranexamsäure in der nichtkardialen Chirurgie

Abstract: Protease inhibitors such as TXA reduce perioperative blood loss and transfusion requirements in selected surgical fields.

Cited by 2 publications

References 92 publications

The effect of prophylactic use of intravenous tranexamic acid in hysterectomy of benign diseases

The effect of prophylactic use of intravenous tranexamic acid in hysterectomy of benign diseases

To Evaluate the Effect of Prophylactic Use of Trenexamic Acid on Bleeding During Elective Lscs. A Study Conducted in Tertiary Care Hospital of Central India.

Contact Info

Product

Resources

About