Prophylactic Vitamin K for Vitamin K Deficiency Bleeding of the Newborn

Martín-López, J.E.; Carlos-Gil, A.M.; López, Rocío Rodríguez; Villegas, R.; Romero, Luis Gabriel Luque; Flores-Moreno, S.

doi:10.1016/j.farmae.2010.05.001

Cited by 9 publications

(4 citation statements)

References 29 publications

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“…It also requires multiple dose regimens, and outcomes are dependent on absorption and compliance. 17,39,40 Injected vitamin K dose is too high 1 mg is given because it stays in the leg muscle and is slowly released over time. This allows for protection against both early and late VKDB.…”

Section: Discussionmentioning

confidence: 99%

Reasons for Refusal of Newborn Vitamin K Prophylaxis: Implications for Management and Education

Hamrick¹,

Gable

Freeman³

et al. 2016

Hospital Pediatrics

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Section: Discussionmentioning

confidence: 99%

Reasons for Refusal of Newborn Vitamin K Prophylaxis: Implications for Management and Education

Hamrick¹,

Gable

Freeman³

et al. 2016

Hospital Pediatrics

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“…Like in a number of other cases, our recommendation is also an experts' opinion based on personal experience with severe and highly lethal late VKDB [6][7][8][9]. According to the facts that "oral vitamin K … has not been tested in randomized trials for its effect on either classic or late VKDB" [29], and that "the results regarding late HDN and prolonged oral prophylaxis are still inconclusive … due to lack of scientific evidence" [31], we suggest this recommendation despite its low level of evidence.…”

Section: Discussionmentioning

confidence: 99%

Late vitamin K deficiency bleeding despite intramuscular prophylaxis at birth - is there a need for additional supplementation?

et al. 2017

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Introduction/Objective. Vitamin K deficiency is common in newborn infants and without prophylaxis there is a risk of vitamin K deficiency bleeding (VKDB). The most frequent prophylactic approach is an intramuscular (IM) injection of vitamin K1 immediately after birth. Its efficiency to prevent late VKDB has been recently questioned by several reports. Based on our experience, we discuss the need for additional vitamin K1 supplementation after its IM administration at birth. Methods. We present a retrospective review of 12 infants, 11 with confirmed and one with probable late VKDB despite IM prophylaxis at birth, who were treated in the two largest tertiary care pediatric hospitals in Serbia during the last 15 years. Results. All the patients were exclusively breastfed. In 11 patients, daily weight gain was normal or increased, and one patient had failure to gain weight. Six infants were previously healthy, three infants received antibiotics prior to bleeding, and in two diarrhea and cholestasis, respectively, existed previously. An intracranial bleeding was documented in nine infants, four of whom died. Conclusion. Low content of phytomenadione in human milk could occasionally be attributed to late VKDB despite postnatal IM injection of vitamin K1 in otherwise healthy, exclusively breastfed infants. This might be aggravated by transient disturbance of vitamin K turnover due to antibiotic use, acute diarrhea, or transient cholestasis. We suggest that an additional vitamin K1 supplementation after postnatal IM prophylaxis could be justified in exclusively breastfed infants.

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“…When choosing a non-pharmacological preparation, a dermal anaesthetic ointment is recommended ( 33 ). It has to be acknowledged that pain can present a great stress for a newborn ( 46 , 47 ).…”

Section: Discussionmentioning

confidence: 99%

Neonatal Prophylaxis: Prevention of Vitamin K Deficiency Haemorrhage and Neonatal Ophthalmia / Neonatalna Profilaksa: Preprečevanje Krvavitev Zaradi Pomanjkanja Vitamina K in Neonatalne Oftalmije

Došler

Petročnik

Mivšek

et al. 2015

Slovenian Journal of Public Health

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IntroductionThe aim of the study was to explore two aspects of neonatal prophylaxis: the application of the vitamin K injection to the newborns and the prophylaxis against chlamydial and gonococcal eye infections, comparing Slovenian and Croatian practices.MethodsA causal non-experimental method of quantitative empirical approach was used. The data was collected by means of predesigned questionnaires. The questionnaires were sent to 14 Slovenian and 32 Croatian birth hospitals. The data was analysed with descriptive statistics and the Kullback test.ResultsVitamin K is applied to all newborns in 9 (out of 14) Slovene and 22 (out of 32) Croatian birth hospitals that returned the questionnaire. The prophylaxis against chlamydial gonococcal eye infections is applied to all newborns in 9 Slovene and 16 Croatian birth hospitals that offered answers to the questionnaire. The majority of Slovene and Croatian birth hospitals perform these procedures in the first hour after birth. The majority of Slovene birth hospitals still apply vitamin K in the gluteal muscle, whereas the majority of Croatian birth hospitals usually use the thigh as an injection site. In Slovenia, 1 % Targesin is used for the prophylaxis against chlamydial and gonococcal eye infections, whereas in Croatia the prevailing medicine is Erythromycin.ConclusionsThe possibility of oral vitamin K application should be offered to parents, and pain management in practice should be discussed. The form of written informed consent could be offered to parents. Health professionals should provide intimacy and exclude routine procedures in the first couple of hours after birth. However, more research is needed as delayed administration might be related to lower efficacy and, as a consequence of that, the safety of newborns is questionable.

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Prophylactic Vitamin K for Vitamin K Deficiency Bleeding of the Newborn

Cited by 9 publications

References 29 publications

Reasons for Refusal of Newborn Vitamin K Prophylaxis: Implications for Management and Education

Reasons for Refusal of Newborn Vitamin K Prophylaxis: Implications for Management and Education

Late vitamin K deficiency bleeding despite intramuscular prophylaxis at birth - is there a need for additional supplementation?

Neonatal Prophylaxis: Prevention of Vitamin K Deficiency Haemorrhage and Neonatal Ophthalmia / Neonatalna Profilaksa: Preprečevanje Krvavitev Zaradi Pomanjkanja Vitamina K in Neonatalne Oftalmije

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