Prophylactic Use of Chloroquine to Prevent Skin Cancer

Knox, John M.

doi:10.1001/archderm.1963.01590150031006

Cited by 16 publications

(4 citation statements)

References 14 publications

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“…Also, oral adm inistration of chloroquine to laboratory animals has inhibited other ultravioletinduced biochemical changes including non-protein-hound SH and the polarographic filtrate reaction [7]. In laboratory and clinical studies the oral adm inistration of chloroquine has decreased the incidence of skin carcinogenesis [2,3], In the present experim ent the addition of chloroquine to the diet of albino rats did not prevent liver succinic dehydrogenase from being altered by ultraviolet irradiation.…”

Section: Discussionmentioning

confidence: 48%

The Effect of Ultraviolet Exposure upon Succinic Dehydrogenase Activity

Ogura¹,

Knox²

1965

Dermatology

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Section: Discussionmentioning

confidence: 48%

The Effect of Ultraviolet Exposure upon Succinic Dehydrogenase Activity

Ogura¹,

Knox²

1965

Dermatology

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“…The examiner did not know which patients took chloroquine or the placebo. Knox and Freeman (1963) reported that patients taking 250 mg. of chloroquine daily for 30 months sufFered no ill effects. A dose of 400 mg. of amodiaquin given daily for 4 months caused no deviation from normal in blood proteins and liver function tests.…”

Section: Resultsmentioning

confidence: 99%

The Treatment of Vitiligo With a Combination of Psoralens and Quinolines.

El‐Mofty

1964

Br J Dermatol

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“…19 Chloroquine apparently does not act as a sunscreening agent. In these studies a significant decrease in the number of cancers of the skin was recorded in certain groups, more so with basal cell than with squamous cell cancers.…”

Section: U R a T I O N O F E X P O S U Rmentioning

confidence: 99%

“…In these studies a significant decrease in the number of cancers of the skin was recorded in certain groups, more so with basal cell than with squamous cell cancers. 19 Chloroquine apparently does not act as a sunscreening agent. The mechanism of chloroquine in reducing cancer is uncertain but in studies of Hiraki16 and others it seems to be due to stromal inhibiting effect rather than a light screening effect.…”

Section: Systemic Preventive Agentsmentioning

confidence: 99%

Carcinogenic effects of solar radiation and prevention measures

Freeman

1968

Cancer

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It is well known that exposure to the sun is the major cause of cancer of the skin—the most common type of cancer encountered in this country. Little is known about the wavelengths responsible for this carcinogenic effect except that it is composed of the shortest wavelengths (290 to 320 mμ) of the solar spectrum. More quantitative information is available about wavelengths and energy requirements for induction of erythema by sun exposure. This may be pertinent to the cancer of the skin problem if it is assumed that erythema represents an early injury which ultimately develops into cancer of the skin. Protection of the individual's skin from sun exposure is the most effective preventive measure now available. This includes avoidance of intense mid‐day exposure and use of topical sunscreen preparations when prolonged exposure is unavoidable. A protective effect has been demonstrated with some systemically administered agents but their use is not yet practical. Evidence that solar‐induced erythema, degeneration and premalignant changes are reversible gives hope that more effective cancer preventive measures may become available for the patient with severe actinic damage.

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Prophylactic Use of Chloroquine to Prevent Skin Cancer

Cited by 16 publications

References 14 publications

The Effect of Ultraviolet Exposure upon Succinic Dehydrogenase Activity

The Effect of Ultraviolet Exposure upon Succinic Dehydrogenase Activity

The Treatment of Vitiligo With a Combination of Psoralens and Quinolines.

Carcinogenic effects of solar radiation and prevention measures

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