Prophylactic use of an ultra-diluted complex on health, metabolism, and performance of weaned Holstein calves and its carryover effect up to first lactation

Silva, T.H. da; Guimarães, I.C.S.B.; Martins, Mellory Martinson; Netto, Arlindo Saran

doi:10.3168/jds.2021-20170

Cited by 3 publications

(1 citation statement)

References 17 publications

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“…The use of ultra-diluted compounds involves the use of highly diluted and dynamized substances to avoid toxicity and stimulate the body's healing responses [17,19]. Even though the mechanisms of action behind the ultra-diluted compounds are not fully understood [20], previous research has already revealed that the use of ultra-diluted compounds in newborn calves was able to decrease the number of episodes of neonatal diarrhea [21], has the potential to reduce the occurrence of digestive disorders and reduce the number of days affected by tick-borne diseases in weaned calves, as well as minimize the risk of culling heifers [22]. On the other hand, other studies did not demonstrate the effect of the use of ultra-diluted compounds in the treatment of mastitis [23] and prevention of endometritis [24].…”

Section: Introductionmentioning

confidence: 99%

The Performance and Metabolism of Dairy Cows Receiving an Ultra-Diluted Complex in the Diet during the Transition Period and Early Lactation

Gheller,

Martins,

Silva

et al. 2023

Animals

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This study evaluated the effects of feeding an ultra-diluted complex to dairy cows during the transition period and early lactation. Thirty multiparous pregnant dairy cows were blocked and randomly assigned to either a placebo control (CON) group or ultra-diluted complex (UD) group. The CON group received a placebo (basal diet + 40 g/cow/day of expanded silicate), while the UD group received the ultra-diluted complex (basal diet + 40 g/cow/day of PeriParto Transição–RealH, composed of ultra-diluted substances + vehicle: expanded silicate). Cows were evaluated from 30 days before the expected calving date until 60 days in milk (DIM) for sample and data collection. Post-partum dry matter intake (DMI) was not affected by the treatment. Cows fed UD had higher DMI relative to BW. Feeding UD increased milk lactose content and decreased milk protein content. Cows fed UD had lower somatic cell counts in the third and fourth week of lactation. Cows fed UD showed a tendency for higher liver health index. Using UD during the transition period and early lactation may benefit liver and udder health of dairy cows with no detrimental effect on milk performance.

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Section: Introductionmentioning

confidence: 99%

The Performance and Metabolism of Dairy Cows Receiving an Ultra-Diluted Complex in the Diet during the Transition Period and Early Lactation

Gheller,

Martins,

Silva

et al. 2023

Animals

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Ultra-diluted complex additive in the diet reveals benefits in the intestinal tract of nursery-phase piglets

Zigovski,

Bez,

Garrido

et al. 2024

Vet Res Commun

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This study aimed to assess an ultra-diluted (UD) complex as a replacement for an antimicrobial performance enhancer in diets on the growth performance, intestinal health, and in ammatory response of nursery piglets. The experiment lasted 37 d and involved 126 animals weaned at 21±1.3 d, with an initial body weight of 5.62±1.16 kg. Piglets were assigned to 6 dietary treatments in a randomized block design with 7 replicates and 3 piglets per pen as experimental unit. The treatments were: positive control -basal diet + 120 mg/kg of chlorohydroxyquinoline (PC); negative control -basal diet without additives (NC); and NC containing 4.5; 6.0; 7.5 or 9.0 kg of UD additive/ton diet. Performance data were calculated, and daily diarrhea occurrence was observed. Blood was collected for hematological analyses. In the end of experiment, one animal per pen was slaughtered for organ weighing, pH analysis and collection of intestinal samples for histopathology. Feces were collected during experiment, and cecal contents at slaughter for microbiological and antibiogram analysis. There was no difference between treatments on performance. Throughout the study, UD levels were equal to PC regarding diarrhea occurrence. Higher levels of UD complex led to higher values of total leukocytes. The 4.5 treatment showed a reduction in total and thermotolerant enterobacteria populations in piglet feces, and an increase in lactic acid bacteria, compared to PC. All treatments showed less duodenal pathological alterations compared to NC. The use of the UD additive, especially at 4.5 kg/ton, may be a good alternative for replacing chlorohydroxyquinoline in piglet diets.

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Ultra-diluted complex additive in the diet reveals benefits in the intestinal tract of nursery-phase piglets

de Paula,

Bez,

Garrido

et al. 2023

Preprint

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This study aimed to assess an ultra-diluted (UD) complex as a replacement for an antimicrobial performance enhancer in diets on the growth performance, intestinal health, and inflammatory response of nursery piglets. The experiment lasted 37 d and involved 126 animals weaned at 21±1.3 d, with an initial body weight of 5.62±1.16 kg. Piglets were assigned to 6 dietary treatments in a randomized block design with 7 replicates and 3 piglets per pen as experimental unit. The treatments were: positive control – basal diet + 120 mg/kg of chlorohydroxyquinoline (PC); negative control – basal diet without additives (NC); and NC containing 4.5; 6.0; 7.5 or 9.0 kg of UD additive/ton diet. Performance data were calculated, and daily diarrhea occurrence was observed. Blood was collected for hematological analyses. In the end of experiment, one animal per pen was slaughtered for organ weighing, pH analysis and collection of intestinal samples for histopathology. Feces were collected during experiment, and cecal contents at slaughter for microbiological and antibiogram analysis. There was no difference between treatments on performance. Throughout the study, UD levels were equal to PC regarding diarrhea occurrence. Higher levels of UD complex led to higher values of total leukocytes. The 4.5 treatment showed a reduction in total and thermotolerant enterobacteria populations in piglet feces, and an increase in lactic acid bacteria, compared to PC. All treatments showed less duodenal pathological alterations compared to NC. The use of the UD additive, especially at 4.5 kg/ton, may be a good alternative for replacing chlorohydroxyquinoline in piglet diets.

show abstract

Prophylactic use of an ultra-diluted complex on health, metabolism, and performance of weaned Holstein calves and its carryover effect up to first lactation

Cited by 3 publications

References 17 publications

The Performance and Metabolism of Dairy Cows Receiving an Ultra-Diluted Complex in the Diet during the Transition Period and Early Lactation

The Performance and Metabolism of Dairy Cows Receiving an Ultra-Diluted Complex in the Diet during the Transition Period and Early Lactation

Ultra-diluted complex additive in the diet reveals benefits in the intestinal tract of nursery-phase piglets

Ultra-diluted complex additive in the diet reveals benefits in the intestinal tract of nursery-phase piglets

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