Prophylactic Treatment of Postperfusion Bleeding Using EACA

Rossi, A; Cernaianu, Aurel C.; Botros, Samir B.; Lemole, Gerald M.; Moore, Roger A.

doi:10.1378/chest.96.1.27

Cited by 140 publications

(29 citation statements)

References 28 publications

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“…18 There was no evidence of a hyperthrombotic state or other side effects in the EACA-treated group. Similarly, prophylactic TA de-creased bleeding after cardiac operations, without coagulation-related complications, in a controlled study of 38 patients by Horrow et al 16 However, the latter could not demonstrate a reduction in the transfusion of red blood cells, but patients in the placebo group received more fresh frozen plasma.…”

Section: Eaca and Ta In Cardiac Surgerymentioning

confidence: 79%

Natural and synthetic antifibrinolytics in cardiac surgery

1992

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In an effort to reduce morbidity associated with transfusion of blood products, the use of antifibrinolytics to decrease bleeding and transfusions after cardiopulmonary bypass ( CPB) is receiving widespread attention. The predominant haemostatic defect induced by CPB and, therefore Afin de rdduire morbiditd associde aux transfusion sanguines, les anesthdsistes et les chirurgiens cardiaques utilisent de plus en plus les antifibrinolytiques darts le but de diminuer le saignement et les besoins transfusionnels secondaires it la circulation extracorporelle ( CEC). Les modifications de l 'hdmostase induites

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Section: Eaca and Ta In Cardiac Surgerymentioning

confidence: 79%

Natural and synthetic antifibrinolytics in cardiac surgery

1992

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“…DelRossi et al [16] concluded that prophylactic treatment with epsilon-aminocaproic acid in cardiac surgery requiring CPB may reduce bleeding in a safe and tolerable manner.…”

Section: Discussionmentioning

confidence: 99%

Influência do ácido épsilon aminocapróico no sangramento e na hemotransfusão pós-operatória em cirurgia valvar mitral

Benfatti¹,

Carli²,

Silva³

et al. 2010

Rev Bras Cir Cardiovasc

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“…[19][20][21][22] Aprotinin is a serine protease inhibitor that has been the most thoroughly investigated for its effect on blood loss during cardiac surgery reviews, s,16,zs,24 For many years, cardiopulmonary bypass surgery has been thought to be associated with increased fibrinolysis 2s-27 that is a major contributor to bleeding. 2s The cause of increased bleeding after ECC has not been elucidated but it is thought to be due to platelet dysfunction as well as to activation of the coagulation cascade leading to excessive fibrinolysis.…”

Section: Discussionmentioning

confidence: 99%

Tranexamic acid reduces blood loss and transfusion in reoperative cardiac surgery

et al. 1997

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Purpose: The objective of this study was to assess the effect of tranexamic acid 0"A), a synthetic antifibrinolytic, on blood loss and the need for transfusion of blood products following repeat cardiac valve surgery. Methods: After ethics committee approval, 41 patients scheduled for reoperative valve replacement were enrolled in this randomized, double blind, placebo controlled study. Patients were randomized to receive TA (I 0 g in 500 ml NSaline) or placebo (NSaline) as an/v bolus over 30 rain, after anaesthesia induction and prior to skin incision. Intraoperative blood loss was assessed by estimating blood volume on drapes, weighing surgical sponges, and measuring suction bottle returns. Postoperative blood loss was measured from mediastinal chest tube drainage following surgery. Blood products were transfused according to a standardized protocol, Results: Patient demographics were similar for age, sex, cardiopulmonary bypass pump time, cross damp time, surgical time, preoperative haemoglobin, coagulation profile, and the number of valves replaced during surgery. Tranexamic acid administration reduced intraoperative blood loss [median (range)] from 1656 (575-6270) to 720 ml (355-5616) (P < 0.01) and postoperative blood loss from 1170 (180-4025) to 538 ml (135-1465) (Intent to Treat n =4 I, P < 0.01 ). The total red blood cells transfused (median, range) was reduced from 1500 (0-9300) ml to 480 (0-2850) ml (P < 0.01) in the TA group. In hospital complications and mortality rates were not reduced in the TA group. Conclusion:Tranexamic acid reduced blood loss and the need for blood product transfusion and appears to be an effective treatment for patients undergoing reoperative cardiac valvular surgery.Objectif : l~valuer l'influence de l'acide trar~xamique (AT), un antifibrinolytique synth&ique, sur les pertes sanguines et le besoin de transfuser des produits sanguins aprEs une r~ol~ration cardiaque valvulaire. M&hodes : AprEs l'approbation du comit~ d'Ethique, 41 patients ont Et~ recrut& dans cette Etude alEatoire, en double aveugle et contr61Ee par placebo. Les patients ont EtE repartis alEatoirement pour recevoir de I'AT (I 0 g dans 500 ml de sol.phys.) ou un placebo (sol. phys,) en bolus iv en 30 rain aprEs l'induction de l'anesthEsie et avant l'incision de la peau. Les pertes sanguines peropEratoires ont EtE (~valuEes en estimant le volume sanguin perdu darts les champs Ol~ratoires, en pesant les compresses, et en mesurant le volume sanguin recueilli par aspiration,/~, la p&iode postopEratoire, le sang recueilli par les drains mEdiastinaux a Et~ mesurE. Les produits du sang ont EtE administrEs selon un protocole standardis~. lld~tdtats : Les donn~3es d~mogr-aphiques ~aient identiques pour I'~ge, le sexe, la durC~ de circulation extracorporelle, du clampage et de la chirurgie, I'h~mogtobine pn~opEratoire, le bilan de la coagulation et le hombre de valves remplac~es. I'administration d'AT a r~duit les pertes sanguines peropEratoires [m~diane (&art)] de 1665 (572--6 270) ~ 720 ml (335--5 616) (P < 0,01) et l...

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Prophylactic Treatment of Postperfusion Bleeding Using EACA

Cited by 140 publications

References 28 publications

Natural and synthetic antifibrinolytics in cardiac surgery

Natural and synthetic antifibrinolytics in cardiac surgery

Influência do ácido épsilon aminocapróico no sangramento e na hemotransfusão pós-operatória em cirurgia valvar mitral

Tranexamic acid reduces blood loss and transfusion in reoperative cardiac surgery

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