Prophylactic treatment of grass pollen‐induced asthma with cetirizine

Dijkman, J. H.; Hekking, P. R. M.; Molkenboer, J. F.; Nierop, Gijsbert P. van; Vanderschueren, R.; Bernheim, Jean; Ganse, Éric Van

doi:10.1111/j.1365-2222.1990.tb03140.x

Cited by 50 publications

(21 citation statements)

References 21 publications

(17 reference statements)

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“…Cetirizine is a second generation, nonsedating highly selective H1 antihistamine, which has been shown to be effective in the prophylaxis and treatment of asthma [507][508][509][510]. In addition to its anti-H1-receptor properties, cetirizine possesses inhibitory properties for basophils [511], and eosinophils [512][513][514].…”

Section: Xanthines and Selective Phosphodiesterase Inhibitorsmentioning

confidence: 99%

Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II)

Kroegel¹,

Warner²,

Jc³

et al. 1994

Eur Respir J

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The second part of this review on eosinophils focuses on biological cell functions and surveys the various deleterious mechanisms involved in the eosinophil-dominated inflammatory reaction. It discusses the possible pathogenic role of eosinophils in several eosinophil-related diseases, such as parasitic infections, interstitial lung disorders and bronchial diseases, graft rejection, vasculitic granulomatous disorders, pleural effusion, and bronchogenic tumours.The final section of the article highlights the possible recent pharmacological and future therapeutic approaches in modifying eosinophil recruitment and function. Eur Respir J., 1994, 7, 743-760 This paper is published as a follow-on to "Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part I)"* (Eur Respir J, 1994; 7: 519-543). Biological cell functionsThe eosinophil mediates its effector functions through various distinct cellular mechanisms, namely nonoxidative, oxidative, and humoral mechanisms ( fig. 7). Nonoxidative mechanismsAs mentioned previously, the three basic proteins as well as eosinophil peroxidase (EPO) have toxic properties independent of molecular oxygen species. For instance, major basic protein (MBP) [323], eosinophil cationic protein (ECP) [324] and EPO in the presence of hydrogen superoxide and a halide [99] kill helminthic parasites in vitro. In addition, these proteins are toxic for tumour cells and/or mammalian cells [325], including human pulmonary parenchyma and interstitial matrix [326,327], cultured human lung epithelial cells [328], and guinea-pig respiratory epithelium [252, 253,329]. Furthermore, it has been demonstrated that MBP damages human bronchial epithelium, which consists of desquamation and destruction of ciliated cells [329]. Finally, release of their granule proteins by plateletactivating factor (PAF)-activated intact eosinophils has been shown to imitate the characteristic pathological findings of airway epithelium in asthma [330].In addition to their cytotoxic action, eosinophil cationic proteins at certain subtoxic concentrations also stimulate other inflammatory cells. For instance, MBP and ECP have been shown to degranulate platelets [305], induce histamine release from mast cells and basophils [240, 245,331], as well as superoxide anion generation and lysosomal enzyme release by human neutrophils [264].Finally, eosinophil proteins may affect airway muscle function and hyperresponsiveness. Recent reports investigating the effects of direct intratracheal instillation of purified eosinophil granule proteins on pulmonary function and airway responsiveness in primates [281,332] have shown that MBP induces a dose-related increase in airway responsiveness to inhaled methacholine. In the same model, both MBP and EPO caused a transient bronchoconstriction immediately after instillation, that resolved within 1 h. Interestingly, other eosinophil granular proteins failed to effect airway responsiveness or pulmonary function.Mode of action. The mode of action of these basic proteins is n...

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Section: Xanthines and Selective Phosphodiesterase Inhibitorsmentioning

confidence: 99%

Pulmonary immune cells in health and disease: the eosinophil leucocyte (Part II)

Kroegel¹,

Warner²,

Jc³

et al. 1994

Eur Respir J

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“…This suggests that HI-receptor blockade could be therapeutically effective against the clinical correlate of acute allergen exposure as seen during the pollen season. Clinical trials have confirmed this, showing terfenadine [17] and cetirizine [18] to be effective treatment for grass pollen asthma. Despite HI-receptor blockade providing good control of symptoms the beneficial effects on airflow measurements were not as impressive.…”

Section: Discussionmentioning

confidence: 81%

A double‐blind, placebo controlled study of the effect of the specific histamine H1‐receptor antagonist, terfenadine, in chronic severe asthma.

Wood‐Baker

Smith

Holgate

1995

Brit J Clinical Pharma

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A double-blind, placebo controlled study of the effect of the specific histamine HI-receptor 6 There was a similar frequency of minor adverse effects reported during placebo (13.6%) and terfenadine (16.7%) treatments.7 Addition of the potent and specific histamine HI-receptor antagonist terfenadine to maintainance asthma treatment had no significant therapeutic benefit in this group of chronic severe asthmatics.

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“…Ketotifen fumarate can bring signifi cant improvement in symptoms, pulmonary function, and airway hyperresponsiveness, as well as exhibiting anti-infl ammatory effects on airway tissue [66] , while azelastine hydrochloride appears to inhibit local infi ltration of infl ammatory cells into the airway [67] . These drugs are expected to prove useful in the treatment of asthma complicated by allergic rhinitis [68][69][70] .…”

Section: Mediator Release Inhibitorsmentioning

confidence: 99%