“…Among the top 30 pathways of pathogenetic genes (Figure 2E), more than 10 pathways are related to stroke. For example, the pathway Cytokine-cytokine receptor interaction is related to cerebral ischemia-reperfusion injury (Wang et al, 2017) and is one of the important active pathways after stroke ; the HIF-1 signaling pathway is related to the neuromodulation (Xu H. et al, 2019;Yang W. et al, 2020), cellular activity (Sugumaran et al, 2020), ischemic angiogenesis , and inflammation (Liu R. et al, 2019;Du et al, 2020). Furthermore, ischemic stroke has 14 similar pathogenetic genes, ACVRL1, APP, ABCC6, CST3, ENG, F7, JAK2, PLAT, PLAU, VHL, SH2B3, PDCD10, KIF1B, and CCM2, and has 48 similar signaling pathways to hemorrhagic stroke, whereas the stroke-related ID C0553692 is related to hemorrhagic stroke and to 29 pathogenetic genes and 48 signaling pathways.…”