1959
DOI: 10.1097/00006534-195911000-00030
|View full text |Cite
|
Sign up to set email alerts
|

Prophylactic postoperative antibiotics; a controlled study of 1007 cases

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
5
0

Year Published

1968
1968
2010
2010

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(5 citation statements)
references
References 0 publications
0
5
0
Order By: Relevance
“…Previous clinical trials have failed to demonstrate any influence on wound infection when antibiotics are started after operation (McKittrick and Wheelock, 1954;Barnes et al, 1959), and experiments in animals have demonstrated that to provide effective prophylaxis against wound infections the antibiotic must be present in the tissues at the time of operation (Burke, 1961 ;Alexander-Williams and Altemeier, 1965). We therefore considered that if antibiotics were started more than 48 h after operation, it was unlikely that they would influence development of wound infection, and therefore such patients were not withdrawn from the study.…”
Section: Discussionmentioning
confidence: 99%
“…Previous clinical trials have failed to demonstrate any influence on wound infection when antibiotics are started after operation (McKittrick and Wheelock, 1954;Barnes et al, 1959), and experiments in animals have demonstrated that to provide effective prophylaxis against wound infections the antibiotic must be present in the tissues at the time of operation (Burke, 1961 ;Alexander-Williams and Altemeier, 1965). We therefore considered that if antibiotics were started more than 48 h after operation, it was unlikely that they would influence development of wound infection, and therefore such patients were not withdrawn from the study.…”
Section: Discussionmentioning
confidence: 99%
“…Firstly, systemic antibiotics have been used in several large trials, but, despite the occasional enthusiastic report (Bernard and Cole, 1964), are generally thought to be ineffective (Barnes et al, 1959;Karl et al, 1966;Report of Ad Hoc Committee, 1964). Cole and Bernard (1961) investigated the use of systemic antibiotics specifically in acute appendicitis and found that such treatment had no value in preventing postoperative wound sepsis.…”
Section: Discussionmentioning
confidence: 99%
“…The types of wounds evaluated were the follow¬ ing: (1) bone cases without foreign body implanta¬ tion; (2) soft tissue cases; (3) foreign body implan¬ tation; (4). "dirty" cases-infected, open fractures, foreign bodies.…”
Section: Methodsmentioning
confidence: 99%