Prophylactic Oropharyngeal Surfactant for Preterm Newborns at Birth
Madeleine C. Murphy,
Jan Miletin,
Claus Klingenberg
et al.
Abstract:ImportancePreterm newborns at risk of respiratory distress syndrome are supported with continuous positive airway pressure (CPAP). Many newborns worsen despite CPAP and are intubated for surfactant administration, an effective therapy for treatment of respiratory distress syndrome. Endotracheal intubation is associated with adverse effects. Pharyngeal administration of surfactant to preterm animals and humans has been reported as an alternative.ObjectiveTo assess whether giving prophylactic oropharyngeal surfa… Show more
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