Prophylactic Implantation of Implantable Cardioverter-Defibrillator for Japanese Patients With Heart Failure

Kuga, Keisuke

doi:10.1253/circj.cj-14-1394

Cited by 2 publications

(3 citation statements)

References 27 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In recent years, the westernization of lifestyles and an aging population have led to a significant increase in HF patients in Japan 27,28 . While the prevention of cardiovascular deaths, including SCD, is known to improve the prognosis in HFrEF patients, 6 there is a problem of underutilization of ICDs, as reported in previous studies, 9,10 and we also often encounter this issue in clinical practice. Recent evidence supporting the primary prevention of ICDs and WCDs for SCD has increased, even in Japan 15–17 .…”

Section: Discussionmentioning

confidence: 94%

“…Nevertheless, underuse of ICD has been reported especially in Asia including Japan 9,10 . Several factors contribute to this underutilization, including physicians' awareness, patients' consciousness, and various social factors, such as those associated with aging and economic considerations in Japan 11–16 .…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, underuse of ICD has been reported especially in Asia including Japan. 9 , 10 Several factors contribute to this underutilization, including physicians' awareness, patients' consciousness, and various social factors, such as those associated with aging and economic considerations in Japan. 11 , 12 , 13 , 14 , 15 , 16 However, in recent years, studies undertaken in Japan, such as the HINODE trial, have shown mortality rates and rates of ventricular arrhythmias as high as those in Western countries.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Multicenter prospective observational study to clarify the current status and clinical outcome in Japanese patients who have an indication for implantable cardioverter defibrillator (ICD) or wearable cardioverter defibrillator (WCD) (TRANSITION JAPAN‐ICD/WCD study): Rationale and design of a prospective, multicenter, observational, comparative study

Ikeya,

Okumura,

Kogawa

et al. 2024

Journal of Arrhythmia

View full text Add to dashboard Cite

BackgroundDespite the positive impact of implantable cardioverter defibrillators (ICDs) and wearable cardioverter defibrillators (WCDs) on prognosis, their implantation is often withheld especially in Japanese heart failure patients with reduced left ventricular ejection fraction (HFrEF) who have not experienced ventricular tachycardia (VT) or ventricular fibrillation (VF) for uncertain reasons. Recent advancements in heart failure (HF) medications have significantly improved the prognosis for HFrEF. Given this context, a critical reassessment of the treatment and prognosis of ICDs and WCDs is essential, as it has the potential to reshape awareness and treatment strategies for these patients.MethodsWe are initiating a prospective multicenter observational study for HFrEF patients eligible for ICD in primary and secondary prevention, and WCD, regardless of device use, including all consenting patients. Study subjects are to be enrolled from 31 participant hospitals located throughout Japan from April 1, 2023, to December 31, 2024, and each will be followed up for 1 year or more. The planned sample size is 651 cases. The primary endpoint is the rate of cardiac implantable electronic device implementation. Other endpoints include the incidence of VT/VF and sudden death, all‐cause mortality, and HF hospitalization, other events. We will collect clinical background information plus each patient's symptoms, Clinical Frailty Scale score, laboratory test results, echocardiographic and electrocardiographic parameters, and serial changes will also be secondary endpoints.ResultsNot applicable.ConclusionThis study offers invaluable insights into understanding the role of ICD/WCD in Japanese HF patients in the new era of HF medication.

show abstract