Prophylactic implantable cardioverter defibrillator therapy in high-risk patients with coronary artery disease

Kolettis, Theofilos M.; Saksena, Sanjeev

doi:10.1016/0002-8703(94)90105-8

Cited by 16 publications

(2 citation statements)

References 23 publications

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“…In MUSTT, sustained ventricular arrhythmia was induced at EPS in 35% of patients. Other smaller studies in similar populations have found equivalent positivity rates 6. If our cohort reacted in the same way there would be 50 positive studies and hence 50 ICD implants.…”

supporting

confidence: 63%

Implementation of the NICE guidelines for the primary prevention of mortality from ventricular tachyarrhythmias: implications for UK electrophysiology centres; activity modelling from the UK-HEART study

Gall¹,

Kearney

Zaman³

et al. 2001

Heart

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supporting

confidence: 63%

Implementation of the NICE guidelines for the primary prevention of mortality from ventricular tachyarrhythmias: implications for UK electrophysiology centres; activity modelling from the UK-HEART study

Gall¹,

Kearney

Zaman³

et al. 2001

Heart

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“…As a result, the positive predictive accuracy of SAECG is generally poor, as shown by a number of clinical reports . Based on the poor performance of this and other noninvasive indices in the evaluation of arrhythmic outcomes, the need for multifactorial risk stratification has been put forward; indeed, an improved positive predictive value for major arrhythmic events, at the range of 50%, was estimated for patients with LPs, frequent premature ventricular contractions, and decreased heart rate variability . Comparable results were reported after combining SAECG with noninvasive indices describing autonomic function (such as heart rate variability, turbulence, and deceleration capacity, as well as baroreceptor sensitivity), repolarization abnormalities (such as QT prolongation, increased QT interval dispersion, or T‐wave alternans), and spontaneous ventricular arrhythmias (such as ventricular couplets or nonsustained VT) .…”

Section: Healed Myocardial Infarctionmentioning

confidence: 99%

Signal‐averaged electrocardiography: Past, present, and future

Gatzoulis

Αρσένος

Trachanas

et al. 2018

Journal of Arrhythmia

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Signal‐averaged electrocardiography records delayed depolarization of myocardial areas with slow conduction that can form the substrate for monomorphic ventricular tachycardia. This technique has been examined mostly in patients with coronary artery disease, but its use has been declined over the years. However, several lines of evidence, derived from hitherto clinical data in patients with healed myocardial infarction, indicate that signal‐averaged electrocardiography remains a valuable tool in risk stratification, especially when incorporated into algorithms encompassing invasive and noninvasive indices. Such an approach can aid the more precise identification of candidates for device therapy, in the context of primary prevention of sudden cardiac death. This article reappraises the value of signal‐averaged electrocardiography as a predictor of arrhythmic outcome in patients with ischemic heart disease and discusses potential future indications.

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Ventricular Arrhythmias During Acute Myocardial Ischemia/Infarction: Mechanisms and Management

Kolettis

2013

Cardiac Arrhythmias

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Ventricular arrhythmias during the acute phase of myocardial infarction are common and account for approximately 80 % of sudden cardiac death cases. A biphasic curve has been observed in various species and possibly applies also in man. The incidence of ventricular arrhythmias in the prehospital phase has remained stable during the past decade, but inhospital rates have declined markedly, mainly due to the widespread use of reperfusion therapies. Ventricular tachycardia and fi brillation are generated by all known arrhythmogenic mechanisms, acting successively or in combination. However, the factors governing the susceptibility to ischemia-related arrhythmias remain incompletely understood. Beta-blockade is the mainstay of treatment; class I agents have been largely superseded by amiodarone, but combined administration may be warranted in diffi cult cases. The effect of ventricular arrhythmias on long-term prognosis needs to be examined in large-scale studies.

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Prophylactic implantable cardioverter defibrillator therapy in high-risk patients with coronary artery disease

Cited by 16 publications

References 23 publications

Implementation of the NICE guidelines for the primary prevention of mortality from ventricular tachyarrhythmias: implications for UK electrophysiology centres; activity modelling from the UK-HEART study

Implementation of the NICE guidelines for the primary prevention of mortality from ventricular tachyarrhythmias: implications for UK electrophysiology centres; activity modelling from the UK-HEART study

Signal‐averaged electrocardiography: Past, present, and future

Ventricular Arrhythmias During Acute Myocardial Ischemia/Infarction: Mechanisms and Management

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