Prophylactic Hypomagnesemia During Cisplatin Therapy

Acute and chronic effects of cisplatin therapy on renal magnesium homeostasis

“…In this study the time elapsed between administration of cisplatin and appearance of In the 18 patients studied and despite that considerable time has passed since the arrest of cisplatin therapy, hypomagnesemia was approximately 15 days, a time shorter than that observed in adults [4,15]. Once hypoplasma Mg and UfMg were significantly lower than control values (1.5 Ϯ 0.21 mg/dl, P Ͻ 0.001; 1.02 Ϯ 0.16 magnesemia had developed it reappeared sooner and sooner after each cisplatin dose [27,28]. mg/dl, PϽ 0.01, respectively).…”