Prophylactic granisetron for post‐spinal anesthesia shivering in cesarean section: A randomized controlled clinical study

Abstract

Prophylactic granisetron effectively reduced incidence and severity of perioperative shivering in a dose-dependent manner, compared to placebo controls.

5-HT3receptor antagonists for the prevention of perioperative shivering undergoing spinal anaesthesia: a systematic review and meta-analysis of randomised controlled trials

“…A total of 27 full-text articles were subsequently assessed for eligibility. 1 8–11 17–38 Finally, 13 studies were included in the present meta-analysis. 1 20–31 There were no disagreements among the authors as to whether the aforementioned studies should be included in the present meta-analysis.…”

“…A total of seven of the included studies 1 20 21 25 26 29 31 clearly described the method of random sequence generation, while nine of the trials 1 20 21 24–29 reported allocation concealment. Double blinding of the participants and personnel was mentioned in eight studies.…”

“…Double blinding of the participants and personnel was mentioned in eight studies. 1 21 22 25 26 28 29 31 Only five studies reported that the assessors were blinded. 1 20 21 26 31 No selective reporting and attrition bias were reported.…”

“… 1 21 22 25 26 28 29 31 Only five studies reported that the assessors were blinded. 1 20 21 26 31 No selective reporting and attrition bias were reported. The summary of risk of bias is shown in figure 2 .…”

“…Perioperative shivering (POS) is a common complication in patients undergoing spinal anaesthesia and has a reported incidence of up to 77.5%. 1 Although shivering is a protective reflex to increase the core temperature by the involuntary contraction of muscles, it also leads to adverse effects such as increasing oxygen consumption and affecting wound healing. 2 3 Unlike general anaesthesia, patients undergoing spinal anaesthesia remain awake during the surgery, and shivering is therefore more likely to cause discomfort in such patients.…”