Prophylactic fluoride treatment and aged bones.

Abstract

BRITISH MEDICAL JOURNAL12 JULY 1975 7. that CO could be implicated in any of the health improvements attributable to smoking cigarettes with unventilated filter-tips. Unfortunately, hopes that tobacco subsitutes may be safer to smoke have not as yet been supported, at least so far as CO production is concerned. Planet cigarettes, which were hastily withdrawn just over a year ago, had a CO yield well above the other brands used in this study. It was also higher than has ever been reported for cigarettes. Cigarette X, which contains a mixture of tobacco (70°,) and tobacco-substitute (30%O), gave a CO yield which was about average for the group of medium and high nicotine brands. The very high CO yield of the cigar tested agrees with previous work6 and also with the evidence that cigarette smokers who switch to smoking cigars often have high COHb levels.14 15Our smoking machine "smoked" with a square-waved rather than bell-shaped puff,16 and the mean duration of each puff was 1-82 instead of 2-0 s. This is unlikely to have affected the absolute values more than negligibly, and would not affect the comparisons between brands. Our aim was to draw attention to the considerable differences between brands rather than to construct a CO yield Medical3Journal, 1975, 3, 73-74 Summary In a double-blind trial with monofluorophosphate (25 mg fluoride per day) given to 460 aged persons (237 treated, 233 control) for eight months no difference was observed in height, admission to hospital, or mortality.Fractures and exacerbation of arthrosis were more frequent in the fluoride group. Vertebral x-ray films showed no difference. The free ionized fluoride levels in the plasma of the fluoride-treated group were still twice as high two months after treatment ended. Fluoride treatment in the prophylaxis of osteoporosis is not recommended unless there is simultaneous measurement of plasma ionized fluoride levels.

Human vertebral bone: Relation of strength, porosity, and mineralization to fluoride content

“…They suggested that although fluoride stimulates new bone formation, the absence of adequate available calcium probably resuits in the formation of poorly calcified matrix, in effect, osteomalacia. Inkovaara et al [19], in a prospective trial in osteoporotic patients, noted an increase in vertebral fractures in those receiving fluoride.…”

Fluoride therapy in postmenopausal osteopenic women: Effect on vertebral and femoral bone density and prediction of bone response

“…It has been reported that NaF could lead to a decrease in cortical bone mass especially in the distal radius [1, 3,10,13]. Some authors [3,[23][24][25], have even reported a higher incidence of non-spine fractures (especially hip fractures). However, analysis of the results reveals that these hip fractures usually occurred in older patients over 70, often in a bone fluorosis context [23], probably related to the combination of higher doses used, or too lengthy a period of treatment often without coadministration of calcium supplement, or renal insufficiency.…”

Supraacetabular and Femoral Head Stress Fracture during Fluoride Treatment

“…To our knowledge they have not been described in steroid-induced osteoporosis treated with fluoride. Similarly, although femoral neck fractures have been reported [4,9,10,12,18], trabecular fatigue fractures in the femoral head have never been noted during fluoride therapy. In our case, the groin pain was related to an unusual supraacetabular fracture, followed by same sided femoral head trabecular fractures.…”