Prophylactic Effects of Hemp Seed Oil on Perimenopausal Depression: A Role of HPA Axis

Abstract

unable to respond flexibly to the fluctuations of ovarian hormones and adjust function in time 5) .Hormone therapy (HT) can effectively alleviate the depression of perimenopausal women 4) . Estradiol (E2) can effectively improve anxiety-like behaviors in female rats 6) . Phytoestrogens are heterocyclic polyphenolic compounds found in plants with estrogen-like effects. Their structure and function are similar to endogenous estrogens. As the alternative method to treat PMD, phytoestrogens have good effects, and the effect of low-dose phytoestrogens (25 mg/day ≤ dose ≤ 100 mg/day) is more significant 7) . Therefore, phytoestrogen replacement therapy has received much attention in recent years.As a traditional Chinese medicine with the homology of medicine and food, hemp seed is the dried and mature fruit