Prophylactic effects of biogenic selenium nanoparticles on acute toxoplasmosis: An in vivo study

Shakibaie, Mojtaba; Ezzatkhah, Fatemeh; Gabal, Esraa; Badparva, Ebrahim; Jahanbakhsh, Sareh; Mahmoudvand, Hossein

doi:10.1016/j.amsu.2020.04.010

Cited by 20 publications

(16 citation statements)

References 18 publications

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“…Furthermore, Dkhil et al demonstrated the protective roles of Se NPs in mice infected with Schistosoma mansoni, indicating that Se NPs could possess therapeutic anti-schistosomal activity in the treatment of intestinal schistosomiasis (Dkhil et al, 2019). Additionally, biogenic Se NPs were also found to show anti-Toxoplasma effects against Toxoplasma gondii in mice with no considerable toxicity, demonstrating the therapeutic effects of Se NPs for toxoplasmosis in vivo (Keyhani et al, 2020a;Keyhani et al, 2020b;Shakibaie et al, 2020). These in vivo findings along with the previously mentioned in vitro results collectively demonstrated that Se NPs could be served as nutritional supplements with powerful anti-parasite effects.…”

Section: Anti-parasite Effects Of Selenium Nanoparticlesmentioning

confidence: 99%

The Advancing of Selenium Nanoparticles Against Infectious Diseases

Lin

Zhang

et al. 2021

Front. Pharmacol.

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Infectious diseases, caused by the direct exposure of cellular or acellular pathogens, are found to be closely associated with multiple inflammation and immune responses, keeping one of the top threats to human health. As an indispensable trace element, Selenium (Se) plays important roles in antioxidant defence and redox state regulation along with a variety of specific metabolic pathways. In recent decades, with the development of novel nanotechnology, Selenium nanoparticles (Se NPs) emerged as a promising agent for biomedical uses due to their low toxicity, degradability and high bioavailability. Taking the advantages of the strong ability to trigger apoptosis or autophagy by regulating reactive oxygen species (ROS), Se NPs have been widely used for direct anticancer treatments and pathogen killing/clearance in host cells. With excellent stability and drug encapsulation capacity, Se NPs are now serving as a kind of powerful nano-carriers for anti-cancer, anti-inflammation and anti-infection treatments. Notably, Se NPs are also found to play critical roles in immunity regulations, such as macrophage and T effector cell activation, which thus provides new possibilities to achieve novel nano-immune synergetic strategy for anti-cancer and anti-infection therapies. In this review, we summarized the progress of preparation methods for Se NPs, followed by the advances of their biological functions and mechanisms for biomedical uses, especially in the field of anti-infection treatments. Moreover, we further provide some prospects of Se NPs in anti-infectious diseases, which would be helpful for facilitating their future research progress for anti-infection therapy.

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Section: Anti-parasite Effects Of Selenium Nanoparticlesmentioning

confidence: 99%

The Advancing of Selenium Nanoparticles Against Infectious Diseases

Lin

Zhang

et al. 2021

Front. Pharmacol.

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“…The number of tachyzoites was significantly lower in mice which had orally received SeNPs before being infected by Toxoplasma than in the control group. The expression levels of IFN-γ TNF-α, IL-12, IL-10, and iNOS considerably increased in the treated group, illustrating the improvement of the immune system, especially the cellular immunity, which caused resistance to the infection (Shakibaie et al 2020). On the other hand, Se supplementation had been suggested in the prevention of right ventricle chamber dilatation and reversion of T. cruzi-induced acute and chronic cardiomyopathy in mice (de Souza et al 2010).…”

Section: The Parasitic Selenoproteome: a Promising Therapeutic Target And Potential Source For Vaccine Antigensmentioning

confidence: 90%

“…Besides their capability to regulate the immune responses during parasitic infections, Se/selenocompounds derivatives have also the ability to directly target such pathogens (Keyhani et al 2020b;Shakibaie et al 2020). One of the Se derivative´s mechanisms of action seems to be the alteration of pathways allowing the parasites to overcome the oxidative stress.…”

Section: Selenocompounds/se Derivatives Targeting Protozoan Proteins Involved In Vital Biological Pathwaysmentioning

confidence: 99%

Selenium and protozoan parasitic infections: selenocompounds and selenoproteins potential

et al. 2022

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The current drug treatments against protozoan parasitic diseases including Chagas, malaria, leishmaniasis, and toxoplasmosis represent good examples of drug resistance mechanisms and have shown diverse side effects. Therefore, the identification of novel therapeutic strategies and drug compounds against such life-threatening diseases is urgent. According to the successful usage of selenium (Se) compounds-based therapy against some diseases, this therapeutic strategy has been recently further underlined against these parasitic diseases by targeting different parasite´s essential pathways. On the other hand, due to the important functions played by parasite selenoproteins in their biology (such as modulating the host immune response), they can be also considered as a novel therapeutic strategy by designing specific inhibitors against these important proteins. In addition, the immunomodulatory potentiality of these compounds to trigger T helper type 1 (Th1) cells and cytokinemediated immune response for the substantial induction of proinflammatory cytokines, thus, Se, selenoproteins, and parasite selenoproteins could be further investigated to find possible vaccine antigens. Herein, we collect and present the results of some studies regarding Se-based therapy against protozoan parasitic diseases and highlight relevant information and some viewpoints that might be insightful to advance toward more effective studies in the future.

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“…Studies have explored the impact of biogenic minerals, which exhibit reduced toxicity due to the coating of plant molecules, on toxoplasmosis. Biogenic selenium orally administered to acutely infected mice reduced the peritoneal tachyzoite load and mortality (141). In chronic experiments, early supplementation with biogenic selenium, zinc, or copper prophylactically reduced the number of brain cysts or completely prevented their development (101)(102)(103).…”

Section: Vitamins and Mineralsmentioning

confidence: 98%

Impact of Plant-Based Foods and Nutraceuticals on Toxoplasma gondii Cysts: Nutritional Therapy as a Viable Approach for Managing Chronic Brain Toxoplasmosis

2022

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Toxoplasma gondii is an obligate intracellular parasite that mainly infects warm-blooded animals including humans. T. gondii can encyst and persist chronically in the brain, leading to a broad spectrum of neurological sequelae. Despite the associated health threats, no clinical drug is currently available to eliminate T. gondii cysts. In a continuous effort to uncover novel therapeutic agents for these cysts, the potential of nutritional products has been explored. Herein, we describe findings from in vitro and in vivo studies that support the efficacy of plant-based foods and nutraceuticals against brain cyst burden and cerebral pathologies associated with chronic toxoplasmosis. Finally, we discuss strategies to increase the translatability of preclinical studies and nutritional products to address whether nutritional therapy can be beneficial for coping with chronic T. gondii infections in humans.

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Prophylactic effects of biogenic selenium nanoparticles on acute toxoplasmosis: An in vivo study

Cited by 20 publications

References 18 publications

The Advancing of Selenium Nanoparticles Against Infectious Diseases

The Advancing of Selenium Nanoparticles Against Infectious Diseases

Selenium and protozoan parasitic infections: selenocompounds and selenoproteins potential

Impact of Plant-Based Foods and Nutraceuticals on Toxoplasma gondii Cysts: Nutritional Therapy as a Viable Approach for Managing Chronic Brain Toxoplasmosis

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