Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis

Chen, Helin; Kan, Qibin; Zhao, Ling; Ye, Gang; He, Xijing; Tang, Huaqiao; Shi, Fei; Zou, Yuanfeng; Liang, Xiaoxia; Song, Xu; Li, Rui; Luo, Jianxun; Li, Yinglun

doi:10.1016/j.biopha.2023.114525

Cited by 12 publications

(7 citation statements)

References 106 publications

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“…These findings suggest that these glycosides possess an inhibitory effect on TRP metabolism into KNY, thereby promoting increased conversion of TRP to serotonin and exerting an antidepressant effect. Chen et al demonstrated the specific protective effect of Tongxieyaofang polysaccharide in mitigating TRP metabolism disorders induced by CUS ( Chen et al, 2023 ). They observed that the administration of polysaccharide solution effectively suppressed the transcriptional activity of IDO1 in the colon, thereby preventing biased TRP metabolism towards the KP.…”

Section: Antidepressant Mechanism Of Natural Plant Polysaccharidesmentioning

confidence: 99%

A review of the pharmacological action and mechanism of natural plant polysaccharides in depression

Yang,

Li,

Zhang

et al. 2024

Front. Pharmacol.

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Depression is a prevalent mental disorder. However, clinical treatment options primarily based on chemical drugs have demonstrated varying degrees of adverse reactions and drug resistance, including somnolence, nausea, and cognitive impairment. Therefore, the development of novel antidepressant medications that effectively reduce suffering and side effects has become a prominent area of research. Polysaccharides are bioactive compounds extracted from natural plants that possess diverse pharmacological activities and medicinal values. It has been discovered that polysaccharides can effectively mitigate depression symptoms. This paper provides an overview of the pharmacological action and mechanisms, intervention approaches, and experimental models regarding the antidepressant effects of polysaccharides derived from various natural sources. Additionally, we summarize the roles and potential mechanisms through which these polysaccharides prevent depression by regulating neurotransmitters, HPA axis, neurotrophic factors, neuroinflammation, oxidative stress, tryptophan metabolism, and gut microbiota. Natural plant polysaccharides hold promise as adjunctive antidepressants for prevention, reduction, and treatment of depression by exerting their therapeutic effects through multiple pathways and targets. Therefore, this review aims to provide scientific evidence for developing polysaccharide resources as effective antidepressant drugs.

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Section: Antidepressant Mechanism Of Natural Plant Polysaccharidesmentioning

confidence: 99%

A review of the pharmacological action and mechanism of natural plant polysaccharides in depression

Yang,

Li,

Zhang

et al. 2024

Front. Pharmacol.

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“…Additionally, using CUMS in rats, Qu et al found that some traditional Chinese medicines (TCM) are capable of mitigating CUMS-induced depressive disorders-behaviors by increasing the abundance of Bacteroidetes and Roseburia (a butyrate-producing bacterium) and reducing the levels of Firmicutes and Ruminococcus [148]. Tongxieyaofang polysaccharide, a classic TCM prescription (containing Radix Paeoniae Alba, Radix Saposhnikoviae, Rhizoma Atractylodis Macrocephalae, and Pericarpium Citri Reticulatae), could also exert antidepressant and anti-inflammatory activities by increasing the relative abundance of butyric acid-producing bacteria like Lachnospiraceae bacterium 28-4 and Ruminococcaceae UCG-014 in a mice model of chronic unpredictable stress [149].…”

Section: Polyphenols and Herbal Medicine As Prebiotics For Depressive...mentioning

confidence: 99%

Microbiota-Induced Epigenetic Alterations in Depressive Disorders Are Targets for Nutritional and Probiotic Therapies

Nohesara,

Abdolmaleky,

Zhou

et al. 2023

Genes

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Major depressive disorder (MDD) is a complex disorder and a leading cause of disability in 280 million people worldwide. Many environmental factors, such as microbes, drugs, and diet, are involved in the pathogenesis of depressive disorders. However, the underlying mechanisms of depression are complex and include the interaction of genetics with epigenetics and the host immune system. Modifications of the gut microbiome and its metabolites influence stress-related responses and social behavior in patients with depressive disorders by modulating the maturation of immune cells and neurogenesis in the brain mediated by epigenetic modifications. Here, we discuss the potential roles of a leaky gut in the development of depressive disorders via changes in gut microbiota-derived metabolites with epigenetic effects. Next, we will deliberate how altering the gut microbiome composition contributes to the development of depressive disorders via epigenetic alterations. In particular, we focus on how microbiota-derived metabolites such as butyrate as an epigenetic modifier, probiotics, maternal diet, polyphenols, drugs (e.g., antipsychotics, antidepressants, and antibiotics), and fecal microbiota transplantation could positively alleviate depressive-like behaviors by modulating the epigenetic landscape. Finally, we will discuss challenges associated with recent therapeutic approaches for depressive disorders via microbiome-related epigenetic shifts, as well as opportunities to tackle such problems.

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“…9 Furthermore, short-chain fatty acids (SCFAs) could promote the differentiation of Treg cells and increase the relative abundance of bacteria that produce butyric acid and propionic acid, which exert anti-inflammatory activity. 10 However, research on the impact of gut microbiota metabolites, such as bile acids and SCFAs, on the depressive behavior caused by enteritis is limited. Further studies are needed to explore the potential therapeutic effects of these metabolites in improving the depressive symptoms associated with enteritis.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Patients with mild cognitive impairment and Alzheimer’s disease also exhibit an increasing trend in the levels of glycine cholic acid (GCA), glycine deoxycholic acid (GDCA), and glycine goose deoxycholic acid (GCDCA) . Furthermore, short-chain fatty acids (SCFAs) could promote the differentiation of Treg cells and increase the relative abundance of bacteria that produce butyric acid and propionic acid, which exert anti-inflammatory activity . However, research on the impact of gut microbiota metabolites, such as bile acids and SCFAs, on the depressive behavior caused by enteritis is limited.…”

Section: Introductionmentioning

confidence: 99%

Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota–Gut–Brain Axis

Chang,

Wang,

Peng

et al. 2024

J. Agric. Food Chem.

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Inflammatory bowel disease (IBD) is a chronic and recurrent disease. Increasing evidence suggests a higher incidence of depression in IBD patients compared with the general population, but the underlying mechanism remains uncertain. Rattan pepper polysaccharide (RPP) is an important active ingredient of rattan pepper, yet its effects and mechanisms on intestinal inflammation and depression-like behavior remain largely unknown. This study aims to investigate the ameliorating effect of RPP on dextran sulfate sodium salt (DSS)-induced intestinal inflammation and depression-like behavior as well as to reveal its mechanism.Our results indicate that RPP effectively ameliorated intestinal microbiota imbalance and metabolic disorders of short-chain fatty acids (SCFAs) and bile acids in mice with DSS-induced inflammation, contributing to the recovery of intestinal Th17/Treg homeostasis. Importantly, RPP effectively alleviated brain inflammation caused by intestinal inflammatory factors entering the brain through the blood−brain barrier. This effect may be attributed to the inhibition of the TLR4/NF-κB signaling pathway, which alleviates neuroinflammation, and the activation of the CREB/BDNF signaling pathway, which improves synaptic dysfunction. Therefore, our findings suggest that RPP may play a role in alleviating DSS-induced gut inflammation and depression-like behavior through the microbiota−gut−brain axis.

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Prophylactic effect of Tongxieyaofang polysaccharide on depressive behavior in adolescent male mice with chronic unpredictable stress through the microbiome-gut-brain axis

Cited by 12 publications

References 106 publications

A review of the pharmacological action and mechanism of natural plant polysaccharides in depression

A review of the pharmacological action and mechanism of natural plant polysaccharides in depression

Microbiota-Induced Epigenetic Alterations in Depressive Disorders Are Targets for Nutritional and Probiotic Therapies

Rattan Pepper Polysaccharide Regulates DSS-Induced Intestinal Inflammation and Depressive Behavior through Microbiota–Gut–Brain Axis

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