Prophylactic Antiviral Activity of Sulfated Glycomimetic Oligomers and Polymers

Soria-Martinez, Laura; Bauer, Sebastian; Giesler, Markus; Schelhaas, Sonja; Materlik, Jennifer; Janus, Kevin; Pierzyna, Patrick; Becker, Miriam; Snyder, Nicole L.; Hartmann, Laura; Schelhaas, Mario

doi:10.1021/jacs.9b13484

Cited by 65 publications

(101 citation statements)

References 70 publications

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“…[ 163 ] In certain cases, the antiviral properties are developed or enhanced after appropriate modification of the polymer, for instance, enhancing its net positive charge [ 164 ] or incorporating sulfate groups. [ 165 ] Other functional groups that provide polymers with antiviral properties are quaternary ammonium groups, sialyl groups, and certain peptides. For instance, HTCC is able to inhibit the common cold pathogen HCoV‐NL63, most likely through interaction with the S protein, which is critical for the coronavirus entry.…”

Section: Covid‐19 Therapeutics: Antiviral Treatments and Vaccinesmentioning

confidence: 99%

Nanotechnology Responses to COVID‐19

Ruiz-Hitzky

Darder

Wicklein

et al. 2020

Adv Healthcare Materials

142

134

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Dedicated to Dr. André Van Meerbeeck and to all the direct and indirect victims of the COVID-19 pandemic Researchers, engineers, and medical doctors are made aware of the severity of the COVID-19 infection and act quickly against the coronavirus SARS-CoV-2 using a large variety of tools. In this review, a panoply of nanoscience and nanotechnology approaches show how these disciplines can help the medical, technical, and scientific communities to fight the pandemic, highlighting the development of nanomaterials for detection, sanitation, therapies, and vaccines. SARS-CoV-2, which can be regarded as a functional core-shell nanoparticle (NP), can interact with diverse materials in its vicinity and remains attached for variable times while preserving its bioactivity. These studies are critical for the appropriate use of controlled disinfection systems. Other nanotechnological approaches are also decisive for the development of improved novel testing and diagnosis kits of coronavirus that are urgently required. Therapeutics are based on nanotechnology strategies as well and focus on antiviral drug design and on new nanoarchitectured vaccines. A brief overview on patented work is presented that emphasizes nanotechnology applied to coronaviruses. Finally, some comments are made on patents of the initial technological responses to COVID-19 that have already been put in practice.

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Section: Covid‐19 Therapeutics: Antiviral Treatments and Vaccinesmentioning

confidence: 99%

Nanotechnology Responses to COVID‐19

Ruiz-Hitzky

Darder

Wicklein

et al. 2020

Adv Healthcare Materials

142

134

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“…The effect of sulphate on several viruses has also been analyzed by Schelhaas at el. In their inquiry, they tested the antiviral effect of sulphated glycomimetic oligomers and polymers as described in Figure 13 and Table 1 [ 130 ]. Spontak et al studied the antiviral and antimicrobial properties of poly[tert-butylstyrene- b -(ethylene-alt-propylene)- b -(styrene sulphonate)- b -(ethylene-alt-propylene)-b-tert-butylstyrene] (TESET).…”

Section: Polymers For Antiviral Activitymentioning

confidence: 99%

“…130]. Spontak et al studied the antiviral and antimicrobial properties of poly[tert-butylstyrene-b-(ethylene-alt-propylene)-b-(styrene sulphonate)-b-(ethylene-alt-propylene)-b-tert-butylstyrene] (TESET).…”

mentioning

confidence: 99%

Polymers in the Medical Antiviral Front-Line

2020

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Antiviral polymers are part of a major campaign led by the scientific community in recent years. Facing this most demanding of campaigns, two main approaches have been undertaken by scientists. First, the classic approach involves the development of relatively small molecules having antiviral properties to serve as drugs. The other approach involves searching for polymers with antiviral properties to be used as prescription medications or viral spread prevention measures. This second approach took two distinct directions. The first, using polymers as antiviral drug-delivery systems, taking advantage of their biodegradable properties. The second, using polymers with antiviral properties for on-contact virus elimination, which will be the focus of this review. Anti-viral polymers are obtained by either the addition of small antiviral molecules (such as metal ions) to obtain ion-containing polymers with antiviral properties or the use of polymers composed of an organic backbone and electrically charged moieties like polyanions, such as carboxylate containing polymers, or polycations such as quaternary ammonium containing polymers. Other approaches include moieties hybridized by sulphates, carboxylic acids, or amines and/or combining repeating units with a similar chemical structure to common antiviral drugs. Furthermore, elevated temperatures appear to increase the anti-viral effect of ions and other functional moieties.

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“…[ 11 ] Such inhibitors are based on multivalent natural carbohydrates or glycoconjugates that bind to lectins with high avidity, thereby blocking them resulting in reduced pathogen adhesion and invasion. [ 12–19 ]…”

Section: Introductionmentioning

confidence: 99%

Temperature‐Controlled Adhesion to Carbohydrate Functionalized Microgel Films: An E. coli and Lectin Binding Study

Paul

Strzelczyk

Schmidt

2021

Macromolecular Bioscience

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The preparation of thermoresponsive mannose functionalized monolayers of poly(N‐isopropylacrylamide) microgels and the analysis of the specific binding of concanavalin A (ConA) and E. coli above and below the lower critical solution temperature (LCST) are shown. Via inhibition and direct binding assays it is found that ConA binding is time‐dependent, where at short incubation times binding is stronger above the LCST. Given larger incubation times, the interaction of ConA to the microgel network is increased below the LCST when compared to temperatures above the LCST, possibly due to increased ConA diffusion and multivalent binding in the more open microgel network below the LCST. For E. coli, which presents only monovalent lectins and is too large to diffuse into the network, binding is always enhanced above the LCST. This is due to the larger mannose density of the microgel layer above the LCST increasing the interaction to E. coli. Once bound to the microgel layer above the LCST, E. coli cannot be released by cooling down below the LCST. Overall, this suggests that the carbohydrate presenting microgel layers enable specific binding where the temperature‐induced transition between swollen and collapsed microgels may increase or decrease binding depending on the receptor size.

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Prophylactic Antiviral Activity of Sulfated Glycomimetic Oligomers and Polymers

Cited by 65 publications

References 70 publications

Nanotechnology Responses to COVID‐19

Nanotechnology Responses to COVID‐19

Polymers in the Medical Antiviral Front-Line

Temperature‐Controlled Adhesion to Carbohydrate Functionalized Microgel Films: An E. coli and Lectin Binding Study

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