Prophylactic Antidepressant Treatment of Interferon-Induced Depression in Chronic Hepatitis C

Udina, Marc; Hidalgo, Diego; Navinés, Ricard; Forns, Xavier; Solá, Ricard; Farré, Magı́; Capuron, Lucile; Vieta, Eduard; Martín‐Santos, Rocío

doi:10.4088/jcp.13r08800

Cited by 42 publications

(29 citation statements)

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“…37 Patients treated with the inflammatory cytokine, IFN-α, developed clinically significant depression. 13,14 Similarly, patients with rheumatoid arthritis, psoriasis, and cancer, treated with anti-TNF, showed improvement in their depression symptoms. [38][39][40] Patients responded to anti-TNF with improvement in the severity of depression with treatment-resistant depression along with high levels of inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

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On-Treatment Improvement of an Emerging Psychosomatic Depressive Disorder Among Salmonella Carriers: A Multicenter Experience from Egypt

et al. 2018

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Background: As physicians in a referral hospital, we observed the association between history of enteric fever and somatic disorders associated with low mood. At the Al-Hussein University Hospital, Cairo and the National Liver Institute Hospital, Menoufia, we receive patients from all over Egypt, including rural areas where enteric fever is endemic. Aim: Here in, 60 Egyptian patients referred to us for evaluation of different somatic disorders are reported. Methods: After extensive evaluations, the patients' symptoms were function-related. Also, their typhoid carrier states were documented, and the severity of depression using Hamilton-D (HAM-D) questionnaire was evaluated and recorded. All patients were treated with ceftriaxone, 2 gm, IV, daily for 15 days. The clinical evaluation and Hamilton score were reassessed at the end of the treatment and 6 weeks thereafter. The patients did not receive any anti-depressant nor anti-anxiety treatment during their course. Typhoid carrier was defined by documenting the history of typhoid fever that was diagnosed by culturing the Salmonella species, and not by serology, isolated from stool culture along with febrile condition, plus the absence of fever in the past 3 weeks. The Widal test was not accepted as a criterion for enrollment. Results: Patients showed clinically significant improvement in the somatic complaints, and their HAM-D score immediately post-treatment that was consolidated for 6 weeks posttreatment completion. Conclusion: In this study, the typhoid carrier was associated with the psychosomatic depression that improved by antibiotic therapy.

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Section: Discussionmentioning

confidence: 99%

“…It has been reported that up to 50% of patients treated with interferon-α developed clinically significant depression. 13,14 This inflammatory model of depression provides a putative link between infection and depression. The association between typhoid fever and neuropsychiatric illness is documented in previous studies.…”

Section: Introductionmentioning

confidence: 99%

On-Treatment Improvement of an Emerging Psychosomatic Depressive Disorder Among Salmonella Carriers: A Multicenter Experience from Egypt

et al. 2018

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“…For example, Udina et al 8 found that the NNT was 12 (95% CI, 7-38) for the efficacy of selective serotonin reuptake inhibitors in the prevention of occurrence of a major depressive episode during antiviral treatment of chronic hepatitis C infection. The interpretation of 95% CIs was discussed in an earlier article in this column.…”

Section: Calculating the Nntmentioning

confidence: 99%

The Numbers Needed to Treat and Harm (NNT, NNH) Statistics: What They Tell Us and What They Do Not

Andrade¹

2015

J. Clin. Psychiatry

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“…Moreover, meta-analyses show increased inflammatory parameters in the blood of patients with MDD [4, 5]. Alternatively, patients undergoing cytokine therapy develop depressive symptoms [6, 7] and experimental-induced inflammation promotes mood deterioration in healthy subjects [8]. Furthermore, elevated inflammatory markers predict a poorer response to antidepressants (AD) while non-responding patients to AD show persistently elevated inflammation [9].…”

Section: Introductionmentioning

confidence: 99%

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants

Martín-Hernández

Caso

Meana

et al. 2018

J Neuroinflammation

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BackgroundStudies show that Toll-like receptors (TLRs), members of the innate immune system, might participate in the pathogenesis of the major depressive disorder (MDD). However, evidence of this participation in the brain of patients with MDD has been elusive.MethodsThis work explores whether the protein expression by immunodetection assays (Western blot) of elements of TLR-4 pathways controlling inflammation and the oxidative/nitrosative stress are altered in postmortem dorsolateral prefrontal cortex of subjects with MDD. The potential modulation induced by the antidepressant treatment on these parameters was also assessed. Thirty MDD subjects (15 antidepressant-free and 15 under antidepressant treatment) were matched for gender and age to 30 controls in a paired design.ResultsNo significant changes in TLR-4 expression were detected. An increased expression of the TLR-4 endogenous ligand Hsp70 (+ 33%), but not of Hsp60, and the activated forms of mitogen-activated protein kinases (MAPKs) p38 (+ 47%) and JNK (+ 56%) was observed in MDD. Concomitantly, MDD subjects present a 45% decreased expression of DUSP2 (a regulator of MAPKs) and reduced (− 21%) expression of the antioxidant nuclear factor Nrf2. Antidepressant treatment did not modify the changes detected in the group with MDD and actually increased (+ 25%) the expression of p11, a protein linked with the transport of neurotransmitters and depression.ConclusionData indicate an altered TLR-4 immune response in the brain of subjects with MDD. Additional research focused on the mechanisms contributing to the antidepressant-induced TLR-4 pathway modulation is warranted and could help to develop new treatment strategies for MDD.Electronic supplementary materialThe online version of this article (10.1186/s12974-018-1294-2) contains supplementary material, which is available to authorized users.

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Prophylactic Antidepressant Treatment of Interferon-Induced Depression in Chronic Hepatitis C

Abstract: Administration of SSRIs before starting antiviral treatment reduces the incidence of interferon-induced depression, with a relatively moderate prophylactic impact and good tolerability.

Cited by 42 publications

References 0 publications

On-Treatment Improvement of an Emerging Psychosomatic Depressive Disorder Among Salmonella Carriers: A Multicenter Experience from Egypt

On-Treatment Improvement of an Emerging Psychosomatic Depressive Disorder Among Salmonella Carriers: A Multicenter Experience from Egypt

The Numbers Needed to Treat and Harm (NNT, NNH) Statistics: What They Tell Us and What They Do Not

Intracellular inflammatory and antioxidant pathways in postmortem frontal cortex of subjects with major depression: effect of antidepressants

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