Prophylactic Antibiotic Drops After Tympanostomy Tube Placement

Ciprofloxacin/dexamethasone drops decrease the incidence of physician and patient outcomes of otorrhea after tube placement

“…The rate of otorrhea in the control group of our study was 39.39%, higher than observed in the control group of other prospective trials, 10-30% [5][6][7][8][9][10][11][12][13]. Part of the explanation for this difference was that we analyzed the patient as a whole instead of ''per-ear''.…”

“…In addition, some patients are unable to attend daycare/school settings with otorrhea, affecting quality of life. Several prospective studies using ototopical agents have shown a reduction in postoperative otorrhea [5][6][7][8][9][10][11][12][13][14]. In a meta-analysis of five Decrease in incidence of otorrhea with ciprofloxacin/dexamethasone drops prospective studies, ototopical antibiotics or antibiotic/steroid combinations administered perioperatively resulted in a reduction of post-operative otorrhea with the greatest benefit in patients with infection or purulent effusion at the time of surgery [4].…”

“…Many trials have studied the impact of ototopical agents on the rate of otorrhea in the post-operative period [5][6][7][8][9][10][11][12][13][14]. These studies have been conducted in patients at University academic settings.…”

Vascular Endothelial Cells Mediate Mechanical Stimulation-Induced Enhancement of Endothelin Hyperalgesia via Activation of P2X2/3Receptors on Nociceptors

“…Since endothelial cells contain endothelin receptors and release ATP in response to mechanical stimulation (Milner et al, 1990), which can act on P2X2/3 receptors on nociceptors to sensitize them (Hester et al, 1995; Ford, 2012), we tested the effect of a P2X2/3 inhibitor (A-317491) on SIEH. When ET-1 was administered 15 min after the administration of A-317491 (1 μg, intradermal), stimulus-induced hyperalgesia was abolished (Fig.…”

Care of the Child with Tympanostomy Tubes: A Guide for the Primary Care Physician

“…Investigations: CBC Cultures of canal and middle ear Antibodies to tetanus and pneumococcus Immunoglobulin levels: IgG, A, M, E & IgG subclasses Treatment: TimentinR (50 mg/kg every 6 hours) (28) ClavulinR (50 mg/kg/day) (28) Post-operative otorrhea is usually the result of reflux of nasopharyngeal secretions into the middle ear or from contaminants from the external canal, and not related to the operative procedure (1,23). When otorrhea occurs, the fluid should be cultured from the middle ear by obtaining an aspirate through the tympanic membrane.…”