Prophylactic and curative anti-ulcerative colitis activity and the possible mechanisms of action of some desert plants

El‐Meligy, Reham M.; Awaad, Amani S.; Soliman, Gamal A.; Bacha, Abir Ben; Alafeefy, Ahmed M.; Kenawy, Sanaa A.

doi:10.3109/14756366.2014.915394

Cited by 18 publications

(14 citation statements)

References 39 publications

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“…Previous studies reported that Cassia fistula, Ocimum basilicum and their mix extracts were able to suppress the pro-inflammatory mediators by blocking the activity of the NF-kB which leads to suppression of mitogen-activated protein kinases (p38, JNK and ERK1/2). Blocking of NF-kBwill resulted in inhibiting of TNF-α [45,46] and consequently the expression of COX-2 well influence NO regulation [47,48]. Values are expressed as mean ±SEM.…”

Section: Hplc Phenolic Compounds Quantificationmentioning

confidence: 99%

Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (Cassia fistula and Ocimum basilicum) Extract as Natural Preservative to Control & Prevent Food Contamination

Hamad¹,

Darwish²,

Abu‐Serie³

et al. 2017

JFNR

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Objectives: Cassia fistula and Ocimum basilicum which are assumed to contain the active components and which are renewable source in fighting infections of microorganisms. The aim of this study was to investigate the antimicrobial activity, the antioxidant activity and anti-inflammatory properties of Cassia fistula and Ocimum basilicum and their mix. Methods and Materials: Cassia fistula and Ocimum basilicum exhibited antimicrobial activity against all of the tested bacteria and yeasts except for Asperigillus spp. that showed high resistance. Results and Discussion: The minimum inhibitory concentration (MIC) values for bacteria and yeast ranged from 3.1 to 6.2 mg/ mL. The antioxidant activity of the Cassia fistula and Ocimum basilicum was evaluated by using DPPH radical scavenging assay. In addition, the amount of total phenolic content (TPC) of Cassia fistula, Ocimum basilicum and their mix was 64.71, 96.42 and 113.07 mg/g, while total flavonoids content was 16.33, 32.66 and 79 mg/g respectively. Vanillin, quercetin and cinnamic acid marked the phenolic profile of the mix. Cytotoxicity results indicated high safety use of the two plants. Conclusion: Our data confirmed convenient and safe use of C. fistula, O. basilicum and their mix as natural antimicrobial and antioxidant. The mix of both extracts can be recommended as natural preservative to be used in food processing to control and prevent food contamination.

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Section: Hplc Phenolic Compounds Quantificationmentioning

confidence: 99%

Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (Cassia fistula and Ocimum basilicum) Extract as Natural Preservative to Control & Prevent Food Contamination

Hamad¹,

Darwish²,

Abu‐Serie³

et al. 2017

JFNR

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“…Colonic segments were excised, opened along its mesenteric border, washed with saline, and were used for macroscopic scoring. The ulcer index (UI) was obtained from the sum of the scores of all lesions for each stomach, and the mean ulcer index (UI mean) was calculated for each group, percent ulcer inhibition of the samples was determined using the equation: [9].…”

Section: Anti-ulcéreuse Activitymentioning

confidence: 99%

In-vivo Antidiarrhoeal and anti-ulcerative activities of the Tetraclinis articulata species of the Cupressaceae family

Ababsa

Derouiche²,

Medjroubi

et al. 2019

Acta Scientifica Naturalis

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In-vivo Antidiarrhoeal and anti-ulcerative activities of the Tetraclinis articulata species of theCupressaceae family the standard drug loperamide (5 mg/kg body weight). After 30 minutes, each animal was give 2 ml of castrol oil orally, after 60 minutes each animal was given 1 mL of charcoal meal via the oral route. After anesthesia with chloroform, all animals were sacrificed after 60 min by opening the abdomen, and the distance covered by the charcoal meal in the intestine, from the pylorus to the caecum, was measured and expressed as the percentage of distance moved [10].Percentage of transit inhibition = 100 × (T 0 -T 1 )/T 0 T 0 : Total length of intestine.

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“…Flavonoids and terpenoids [195] Araliaceae Panax quinquefolius L. Hydroalcoholic extract of the root 11.9 mg/kg; p. o.…”

Section: Family Asteraceaementioning

confidence: 99%

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

et al. 2017

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Ulcerative colitis is a chronic inflammatory condition whose treatment includes aminosalicylates, corticosteroids, and immunomodulators. Medicinal plants seem to be an important alternative treatment for this condition. They have been the subject of a great number of studies in recent years. This study was conducted to systematically review the medicinal plants tested in experimental models of ulcerative colitis. We conducted a systematic literature search through specialized databases (PUBMED, SCOPUS, EMBASE, MEDLINE, LILACS, SCIELO, and SCISEARCH) and selected articles published between January 2000 and June 21, 2016 by using ?medicinal plants? and ?ulcerative colitis? as key words. Sixty-eight studies were included, and the families Asteraceae and Lamiaceae presented the largest number of studies, but plants from several other families were cited; many of them have shown good results in experimental animals. However, only a few species (such as Andrographis paniculata and Punica granatum) have undergone clinical tests against ulcerative colitis, and the observation that many preclinical studies reviewed are purely descriptive has certainly contributed to this fact. Chemical constituents (mainly flavonoids and terpenes) seem to play a role in the effects of the plants. Thus, the data herein reviewed reinforce the potential of medicinal plants as a source of alternative approaches to the treatment of ulcerative colitis.

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Prophylactic and curative anti-ulcerative colitis activity and the possible mechanisms of action of some desert plants

Cited by 18 publications

References 39 publications

Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (<i>Cassia fistula</i> and <i>Ocimum basilicum</i>) Extract as Natural Preservative to Control & Prevent Food Contamination

Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (<i>Cassia fistula</i> and <i>Ocimum basilicum</i>) Extract as Natural Preservative to Control & Prevent Food Contamination

In-vivo Antidiarrhoeal and anti-ulcerative activities of the Tetraclinis articulata species of the Cupressaceae family

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

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Prophylactic and curative anti-ulcerative colitis activity and the possible mechanisms of action of some desert plants

Cited by 18 publications

References 39 publications

Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (<i>Cassia fistula</i> and <i>Ocimum basilicum</i>) Extract as Natural Preservative to Control &amp; Prevent Food Contamination

Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (<i>Cassia fistula</i> and <i>Ocimum basilicum</i>) Extract as Natural Preservative to Control &amp; Prevent Food Contamination

In-vivo Antidiarrhoeal and anti-ulcerative activities of the Tetraclinis articulata species of the Cupressaceae family

Medicinal Plants in the Treatment of Colitis: Evidence from Preclinical Studies

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Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (<i>Cassia fistula</i> and <i>Ocimum basilicum</i>) Extract as Natural Preservative to Control & Prevent Food Contamination

Antimicrobial, Antioxidant and Anti-inflammatory Characteristics of Combination (<i>Cassia fistula</i> and <i>Ocimum basilicum</i>) Extract as Natural Preservative to Control & Prevent Food Contamination