1990
DOI: 10.1007/bf03005618
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Prophylactic administration of histamine1 and histamine2 receptor blockers in the prevention of protamine-related haemodynamic effects

Abstract: Avec le concours de candidats g~ une revascularisation coronarienne, nous avons mesurg l'effet de l'utilisation de bloqueurs des r~cepteurs histaminiques H t et 1-12 avant l' injection de protamine, sur la r~ponse hdmodynamique d cette derni&e. Les patients du Groupe 1 ne recevaient aucun pr~-traitement rnais nous injections prophylactiquement de la dyphenhydramine (anti-Hi) et de la cim~tidine (anti-H2) d ceux du Groupe H. Les moyennes des pressions art~rielles systoliques, diastoliques, des tensions veineuse… Show more

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Cited by 24 publications
(18 citation statements)
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“…Patients given H1-and H2-receptor blockers prior to protamine administration suffered less adverse hemodynamic effects than patients without histamine blockers [38]. Plasma histamine increases induced by protamine may depend both on the route and speed of drug administration [39,40].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Patients given H1-and H2-receptor blockers prior to protamine administration suffered less adverse hemodynamic effects than patients without histamine blockers [38]. Plasma histamine increases induced by protamine may depend both on the route and speed of drug administration [39,40].…”
Section: Discussionmentioning
confidence: 99%
“…Infusion of protamine sulphate may cause hemodynamic changes ranging from mild hypotension to anaphylactic reactions [38]. Patients given H1-and H2-receptor blockers prior to protamine administration suffered less adverse hemodynamic effects than patients without histamine blockers [38].…”
Section: Discussionmentioning
confidence: 99%
“…H 2 receptors are involved in gastric acid secretion as well as in the activation of lymphocytes, neutrophils, and endothelial cells. During cardiac surgery, cimetidine has been used to reduce the anaphylactic reaction produced by protamine‐heparin complex following reversal of heparin by protamine .…”
Section: Pulsatile Flowmentioning
confidence: 99%
“…[8] studied the effect of pre-treatment with histamine blockers in 15 patients and compared to 15 patients without pre-treatment. A drop in blood pressure was noted in the group without pre-treatment, but no actual anaphylactic reaction was registered.…”
Section: Prospective Studiesmentioning
confidence: 99%