Propess versus prostin for induction of labour in term primiparous women

Hung, Cheng‐Chieh; Chen, Han-Ying; Kang, Jessica; Tai, Yi-Yun; Lin, Song; Lee, Chien‐Nan

doi:10.1016/j.jfma.2023.02.006

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…This result suggests that appropriate use, in compliance with the removal criteria, can minimize adverse events without decreasing efficacy. While a few studies comparing removable and non-removable preparations have shown no difference in the frequency of hyperstimulation in either case [ 17 , 18 ], no large-scale studies have addressed the prognosis of infants. Notably, the results of this study showed no adverse effects on neonatal outcomes after the introduction of a CR-DVI.…”

Section: Discussionmentioning

confidence: 99%

Impact of Introducing a Controlled-Release Dinoprostone Vaginal Insert for Labor Induction: A Retrospective Single-Center Study in Japan

Shindo,

Aoki,

Nakanishi

et al. 2024

Cureus

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Aim: Cervical ripening is commonly performed before oxytocin administration during labor induction in pregnant women with an unfavorable cervix. In Japan, a controlled-release Dinoprostone vaginal insert (CR-DVI) was approved in 2020. Although many studies have compared the mechanical methods of ripening and prostaglandins, few have examined the impact of additional options for labor induction. This study aimed to assess the impact of CR-DVI as an additional option for labor induction in women with an unfavorable cervix. Methods: In this single-center retrospective study conducted in Japan, 265 participants were divided into two groups: before (January 2018 to May 2020) and after (June 2020 to November 2022) CR-DVI introduction. Before CR-DVI was introduced, hygroscopic dilators were used for all cases instead. On the other hand, after the introduction of CR-DVI, the first choice for cervical ripening was CR-DVI. The CR-DVI was retained vaginally for up to 12 hours after insertion. However, if hyper-stimulation or non-reassuring fetal status was suspected, or if a new membrane rupture occurred, it was removed immediately according to the removal criteria. Oxytocin infusions were used during both periods if needed. We compared delivery and neonatal outcomes between the groups. Results: The 265 participants were divided into two groups: before (n=116) and after (n=149) CR-DVI introduction. There were no significant differences in maternal characteristics except for the primiparous proportion. CR-DVI was used in 93% of cases after introduction. Hygroscopic dilators also continued to be used; however, their use decreased to about 34%. The vaginal delivery rate was significantly higher after the introduction of CR-DVI than before its introduction (50.9% vs. 66.4%; p=0.01). Multivariable analysis revealed a significantly higher rate of vaginal delivery after CR-DVI introduction. Of the 149 cases in which a CR-DVI was used, 111 (79.9%) were removed before 12 hours. There were no significant differences in neonatal outcomes. Conclusion: The rate of vaginal delivery was higher after CR-DVI introduction than before its introduction, and adverse pregnancy outcomes did not increase. Therefore, introducing CR-DVI as an option for labor induction may increase the probability of vaginal delivery. Safety can also be ensured by adhering to the removal criteria.

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Section: Discussionmentioning

confidence: 99%

Impact of Introducing a Controlled-Release Dinoprostone Vaginal Insert for Labor Induction: A Retrospective Single-Center Study in Japan

Shindo,

Aoki,

Nakanishi

et al. 2024

Cureus

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“…Nowadays, in industrialized countries, the IOL rate ranges from approximately 24.5% to 33%, highlighting the significance of ensuring the efficacy and safety of IOL procedures. 12 Due to the widespread application of PGE2 or oxytocin for IOL in Taiwan, 9,13 it is essential to determine the superior option between oxytocin and PGE2.…”

Section: Introductionmentioning

confidence: 99%

Oxytocin and vaginal dinoprostone in labor induction: A systematic review and meta‐analysis

Chang,

Li,

Ding

2024

Intl J Gynecology & Obste

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BackgroundThe comparison between prostaglandin E2 (PGE2) and oxytocin and for induction of labor (IOL) remains controversial.ObjectiveThe present study aimed to determine the safety and efficacy of these two agents in IOL.Search StrategyPubMed, Embase, Web of Science, Cochrane Library, and ClinicalTrials.gov. from the establishment of the database to April 23, 2023.Selection CriteriaA search was conducted with keywords “labor, induction, prostaglandin E2/PGE2/dinoprostone, and oxytocin”. Only randomized clinical trials comparing oxytocin and vaginal dinoprostone in women who were at least late preterm (gestational age [GA] ≥34 weeks), singleton pregnant, and had intact membranes were enrolled for further meta‐analysis.Data Collection and AnalysisWe conducted both a descriptive analysis and a meta‐analysis. In the meta‐analysis, we utilized the Mantel–Haenszel random effects model to analyze dichotomous data, employing the relative risk (RR) as the effect measure along with 95% confidence intervals (CIs). The study quality was evaluated using Cochrane Collaboration's risk of bias assessment tool (RoB 2). A random‐effects model was applied for the meta‐analysis.Main ResultsAfter screening 3303 articles from five databases, a total of nine randomized controlled studies composed of 1071 patients were included. Our analysis included 534 patients in the PGE2 group and 537 patients in the oxytocin group. The pooled estimate of vaginal deliveries following PGE2 induction stood at 84.2%, while after oxytocin induction, it was 79.8%. The meta‐analysis showed no statistical difference between the two groups in terms of the rate of vaginal delivery (pooled RR, 1.05; 95% CI: 0.95–1.16; P value for Q, 0.001; I2, 71.14%), cesarean section (pooled RR, 0.84; 95% CI: 0.52–1.35; P value for Q, 0.007; I2, 61.69%) and induction‐delivery interval (pooled standard mean difference, 0.09; 95% CI: −0.67 to 0.85; P value for Q, 0.000; I2, 96.45%). Since the results for fetal distress and uterine hyperstimulation were consistent across all enrolled studies, no further meta‐analysis was conducted.ConclusionsWhen amalgamating the available literature, it implies that oxytocin was found to have similar effects as PGE2 on delivery outcomes and safety concerns in pregnant women with GA ≥36 weeks. Although the uterine cervix was unfavorable, both low and high doses of oxytocin were feasible for IOL.

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Kao¹

2023

Journal of the Formosan Medical Association

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Propess versus prostin for induction of labour in term primiparous women

Cited by 3 publications

References 17 publications

Impact of Introducing a Controlled-Release Dinoprostone Vaginal Insert for Labor Induction: A Retrospective Single-Center Study in Japan

Impact of Introducing a Controlled-Release Dinoprostone Vaginal Insert for Labor Induction: A Retrospective Single-Center Study in Japan

Oxytocin and vaginal dinoprostone in labor induction: A systematic review and meta‐analysis

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