Property optimization of Zr-Ti-X (X = Ag, Al) metallic glass via combinatorial development aimed at prospective biomedical application

Jabed, Akib; Khan, Muhammad Mudasser; Camiller, Justin; Greenlee‐Wacker, Mallary C.; Haider, Waseem; Shabib, Ishraq

doi:10.1016/j.surfcoat.2019.05.036

Cited by 29 publications

(15 citation statements)

References 90 publications

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“…In recent studies, the corrosion resistance of Zr-based metallic glasses in varied simulated environments was investigated by potentiodynamic polarization tests. The reported environments included: Phosphate Buffered Saline (PBS) [ 32 , 40 , 43 , 47 , 49 , 50 , 51 , 52 , 53 , 54 ], Simulated Body Fluid (SBF) [ 41 , 45 , 48 , 59 ], Artificial Blood Plasma Solution (ABP) [ 50 , 51 , 52 ], Artificial Saliva Solution (ASS) [ 50 , 51 , 52 ], Hank’s Balanced Saline Solution (HBSS) [ 50 , 51 , 52 , 55 , 60 ], Ringer’s solution [ 31 ], …”

Section: Zr-based Metallic Glassesmentioning

confidence: 99%

“…Strong antibacterial activity was also demonstrated for the similar ZrCuAlAg composition [ 79 ]. Moreover, the research according to JIS Z 2081 standard, by Jabed et al [ 54 ] demonstrated the effectiveness of ZrTiAg thin film metallic glass in antibacterial activity against S. aureus indicated by a 48 to 97% reduction in colony-forming units in comparison to uncoated Si substrate. The ZrTiAl metallic glass was not so effective due to the lack of antibacterial elements.…”

Section: Zr-based Metallic Glassesmentioning

confidence: 99%

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Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Biały

Hasiak

Łaszcz

2022

JFB

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The continuous development of novel materials for biomedical applications is resulting in an increasingly better prognosis for patients. The application of more advanced materials relates to fewer complications and a desirable higher percentage of successful treatments. New, innovative materials being considered for biomedical applications are metallic alloys with an amorphous internal structure called metallic glasses. They are currently in a dynamic phase of development both in terms of formulating new chemical compositions and testing their properties in terms of intended biocompatibility. This review article intends to synthesize the latest research results in the field of biocompatible metallic glasses to create a more coherent picture of these materials. It summarizes and discusses the most recent findings in the areas of mechanical properties, corrosion resistance, in vitro cellular studies, antibacterial properties, and in vivo animal studies. Results are collected mainly for the most popular metallic glasses manufactured as thin films, coatings, and in bulk form. Considered materials include alloys based on zirconium and titanium, as well as new promising ones based on magnesium, tantalum, and palladium. From the properties of the examined metallic glasses, possible areas of application and further research directions to fill existing gaps are proposed.

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Section: Zr-based Metallic Glassesmentioning

confidence: 99%

Section: Zr-based Metallic Glassesmentioning

confidence: 99%

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Biały

Hasiak

Łaszcz

2022

JFB

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“…Instead, the contact angle remains constant at ∼100 • for all here-studied FeCoCr-Ag alloys. This suggests that the influence of surface structure on bacterial adhesion can be ignored, and the obvious variation of antibacterial activity can be attributed to the change of Ag content [20].…”

Section: Discussionmentioning

confidence: 99%

Combinatorial development of antibacterial FeCoCr-Ag medium entropy alloy

et al. 2023

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Antibacterial activity and mechanical properties of FeCoCr-Ag medium entropy alloys were studied via combinatorial fabrication paired with high-throughput characterizations. It was found that the antibacterial activity and mechanical properties exhibit non-linear dependence on the content of Ag addition. Within the studied alloys, (FeCoCr)80Ag20 possesses an optimized combination of different properties for potential applications as antibacterial coating materials. The underlying mechanism is ascribed to the formation of a dual-phase structure that leads to competition between the role of Ag phase and FeCoCr phase at different Ag content. The results not only demonstrate the power and effectiveness of combinatorial methods in multi-parameter optimization but also indicate the potential of high entropy alloys as antibacterial materials.

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“…In the present study, thick-films of a proposed antimicrobial HEA CoCuAgNi(Si) are prepared by combinatorial sputtering and tested for their potential application as self-sanitizing surfaces. Combinatorial sputtering has been previously demonstrated as a high throughput approach to designing antimicrobial surfaces 53 – 55 . The antimicrobial activity of the as-prepared alloy is tested against four non-pathogenic surrogates representing infectious human pathogens including the bacteriophages Pseudomonas phage Phi6, which is similar in size and structure to SARS-CoV-2, including the surface spike proteins 56 , and the phage MS2, a non-encapsulated spike-less virus and a surrogate for the human novovirus 57 .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of a multi-component alloy

Murray

Bryan

Garfinkel

et al. 2022

Sci Rep

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High traffic touch surfaces such as doorknobs, countertops, and handrails can be transmission points for the spread of pathogens, emphasizing the need to develop materials that actively self-sanitize. Metals are frequently used for these surfaces due to their durability, but many metals also possess antimicrobial properties which function through a variety of mechanisms. This work investigates metallic alloys comprised of several metals which individually possess antimicrobial properties, with the target of achieving broad-spectrum, rapid sanitation through synergistic activity. An entropy-motivated stabilization paradigm is proposed to prepare scalable alloys of copper, silver, nickel and cobalt. Using combinatorial sputtering, thin-film alloys were prepared on 100 mm wafers with ≈50% compositional grading of each element across the wafer. The films were then annealed and investigated for alloy stability. Antimicrobial activity testing was performed on both the as-grown alloys and the annealed films using four microorganisms—Phi6, MS2, Bacillus subtilis and Escherichia coli—as surrogates for human viral and bacterial pathogens. Testing showed that after 30 s of contact with some of the test alloys, Phi6, an enveloped, single-stranded RNA bacteriophage that serves as a SARS-CoV-2 surrogate, was reduced up to 6.9 orders of magnitude (> 99.9999%). Additionally, the non-enveloped, double-stranded DNA bacteriophage MS2, and the Gram-negative E. coli and Gram-positive B. subtilis bacterial strains showed a 5.0, 6.4, and 5.7 log reduction in activity after 30, 20 and 10 min, respectively. Antimicrobial activity in the alloy samples showed a strong dependence on the composition, with the log reduction scaling directly with the Cu content. Concentration of Cu by phase separation after annealing improved activity in some of the samples. The results motivate a variety of themes which can be leveraged to design ideal antimicrobial surfaces.

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Property optimization of Zr-Ti-X (X = Ag, Al) metallic glass via combinatorial development aimed at prospective biomedical application

Cited by 29 publications

References 90 publications

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Combinatorial development of antibacterial FeCoCr-Ag medium entropy alloy

Antimicrobial properties of a multi-component alloy

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Property optimization of Zr-Ti-X (X = Ag, Al) metallic glass via combinatorial development aimed at prospective biomedical application

Cited by 29 publications

References 90 publications

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Review on Biocompatibility and Prospect Biomedical Applications of Novel Functional Metallic Glasses

Combinatorial development of antibacterial FeCoCr-Ag medium entropy alloy

Antimicrobial properties of a multi-component alloy

Contact Info

Product

Resources

About

Property optimization of Zr-Ti-X (X = Ag, Al) metallic glass via combinatorial development aimed at prospective biomedical application